MolNFT v1 · #31699 · protein

P53N (fragment 33-60) bound to RPA70N

2B3G · Replication protein a 70 kda DNA-binding subunit: “P53N (fragment 33-60) bound to RPA70N”. X-ray diffraction, 1 pocket (best druggability 0.46). MolNFT v1 #31699 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 2B3G
Type: protein
Length: 141 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Replication protein a 70 kda DNA-binding subunit; Cellular tumor antigen P53
UniProt: P27694, P04637
Pockets: 1 · best druggability 0.46

Structure

x-ray diffraction · 2 distinct chains · 28% helix, 35% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Replication protein a 70 kda DNA-binding subunit	protein	117	20% helix, 43% strand	P27694
B	Cellular tumor antigen P53	protein	24	67% helix, 0% strand	P04637

Pockets

1 pocket found on a 1 Å grid, 0 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	135	0.46	0.77	21	empty

Interfaces

1 interface between chains.

A–B · 543 Å² buried · 11 hydrogen bonds · protein-protein

Compared structures

2B3G · p53N (fragment 33-60) bound to RPA70N · the same entry in another collection · chain A against A, TM-score 1.00
P27694 · AlphaFold monomer V2.0 prediction for replication protein a 70 kda DNA-binding subunit… · a predicted model of the same protein · chain A against A, TM-score 0.95

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P27694
Every structure of UniProt P04637
Elsewhere: RCSB PDB 2B3G · PDBe 2B3G · UniProt P27694 · UniProt P04637

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