UniProt P27694
Replication protein A 70 kDa DNA-binding subunit (P27694)
Replication protein A 70 kDa DNA-binding subunit (UniProt P27694): 58 experimental structures on GenesisL1, 2 pockets. Binding sites, pockets, druggability and 3D structures in GL1X.
- UniProt
- P27694
- Protein
- Replication protein A 70 kDa DNA-binding subunit
- Experimental structures
- 58
- Predicted models
- 0
- Pockets
- 2 · 1 record with a druggable one
Structures
58 records of P27694 in the MolNFT archive: 58 experimental, 0 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 1EWI | Human replication protein a: global fold of the N-terminal rpa-70 domain reveals a basic cleft and… | solution nmr | A | — | — |
| 1EWI | Human replication protein a: global fold of the N-terminal rpa-70 domain reveals a basic cleft and… | solution nmr | A | — | — |
| 1FGU | Ssdna-binding domain of the large subunit of replication protein a | x-ray diffraction | A, B | — | — |
| 1FGU | Ssdna-binding domain of the large subunit of replication protein a | x-ray diffraction | A, B | — | — |
| 1JMC | Single stranded DNA-binding domain of human replication protein a bound to single stranded DNA… | x-ray diffraction | A | — | — |
| 1JMC | Single stranded DNA-binding domain of human replication protein a bound to single stranded DNA… | x-ray diffraction | A | — | — |
| 1L1O | Structure of the human Replication Protein A (RPA) trimerization core | x-ray diffraction | C, F | — | — |
| 1L1O | Structure of the human replication protein a (rpa) trimerization core | x-ray diffraction | C, F | — | — |
| 2B29 | N-terminal domain of the RPA70 subunit of human replication protein A. | x-ray diffraction | A | — | — |
| 2B29 | N-terminal domain of the RPA70 subunit of human replication protein a. | x-ray diffraction | A | — | — |
| 2B3G | p53N (fragment 33-60) bound to RPA70N | x-ray diffraction | A | — | — |
| 2B3G | P53N (fragment 33-60) bound to RPA70N | x-ray diffraction | A | — | — |
| 4IJH | Fragment-based Discovery of Protein-Protein Interaction Inhibitors of Replication Protein A | x-ray diffraction | A | — | — |
| 4IJH | Fragment-based discovery of protein-protein interaction inhibitors of replication protein a | x-ray diffraction | A | — | — |
| 4IJL | Fragment-based Discovery of Protein-Protein Interaction Inhibitors of Replication Protein A | x-ray diffraction | A | — | — |
| 4IJL | Fragment-based discovery of protein-protein interaction inhibitors of replication protein a | x-ray diffraction | A | — | — |
| 4IPC | Structure of the N-terminal domain of RPA70, E7R mutant | x-ray diffraction | A | — | — |
| 4IPC | Structure of the N-terminal domain of RPA70, E7R mutant | x-ray diffraction | A | — | — |
| 4IPD | Structure of the N-terminal domain of RPA70, E100R mutant | x-ray diffraction | A | — | — |
| 4IPD | Structure of the N-terminal domain of RPA70, E100R mutant | x-ray diffraction | A | — | — |
| 4IPG | Structure of the N-terminal domain of RPA70, E7R, E100R mutant | x-ray diffraction | A | — | — |
| 4IPG | Structure of the N-terminal domain of RPA70, E7R, E100R mutant | x-ray diffraction | A | — | — |
| 4IPH | Structure of N-terminal domain of RPA70 in complex with VU079104 inhibitor | x-ray diffraction | A | — | — |
| 4IPH | Structure of N-terminal domain of RPA70 in complex with VU079104 inhibitor | x-ray diffraction | A | — | — |
| 4LUO | Fragment-Based Discovery of a Potent Inhibitor of Replication Protein A Protein-Protein Interactions | x-ray diffraction | A | — | — |
| 4LUO | Fragment-based discovery of a potent inhibitor of replication protein a protein-protein interactions | x-ray diffraction | A | — | — |
| 4LUV | Fragment-Based Discovery of a Potent Inhibitor of Replication Protein A Protein-Protein Interactions | x-ray diffraction | A | — | — |
| 4LUV | Fragment-based discovery of a potent inhibitor of replication protein a protein-protein interactions | x-ray diffraction | A | — | — |
| 4LUZ | Fragment-Based Discovery of a Potent Inhibitor of Replication Protein A Protein-Protein Interactions | x-ray diffraction | A | — | — |
| 4LUZ | Fragment-based discovery of a potent inhibitor of replication protein a protein-protein interactions | x-ray diffraction | A | — | — |
| 4LW1 | Fragment-Based Discovery of a Potent Inhibitor of Replication Protein A Protein-Protein Interactions | x-ray diffraction | A | — | — |
| 4LW1 | Fragment-based discovery of a potent inhibitor of replication protein a protein-protein interactions | x-ray diffraction | A | — | — |
| 4LWC | Fragment-Based Discovery of a Potent Inhibitor of Replication Protein A Protein-Protein Interactions | x-ray diffraction | A | — | — |
| 4LWC | Fragment-based discovery of a potent inhibitor of replication protein a protein-protein interactions | x-ray diffraction | A | — | — |
| 4NB3 | Crystal structure of RPA70N in complex with a 3,4 dichlorophenylalanine ATRIP derived peptide | x-ray diffraction | A, B | — | — |
| 4NB3 | Crystal structure of RPA70N in complex with a 3,4 dichlorophenylalanine atrip derived peptide | x-ray diffraction | A, B | — | — |
| 4O0A | Fragment-Based Discovery of a Potent Inhibitor of Replication Protein A Protein-Protein Interactions | x-ray diffraction | A | — | — |
| 4O0A | Fragment-based discovery of a potent inhibitor of replication protein a protein-protein interactions | x-ray diffraction | A | — | — |
| 4R4C | Structure of RPA70N in complex with 5-(4-((4-(5-carboxyfuran-2-yl)-2-chlorobenzamido)methyl)phenyl)… | x-ray diffraction | A | — | — |
| 4R4C | Structure of RPA70N in complex with 5-(4-((4-(5-carboxyfuran-2-yl)-2… | x-ray diffraction | A | — | — |
| 4R4I | Structure of RPA70N in complex with 5-(4-((6-(5-carboxyfuran-2-yl)-1-thioxo-3,4-dihydroisoquinolin-2… | x-ray diffraction | A | — | — |
| 4R4I | Structure of RPA70N in complex with 5-(4-((6-(5-carboxyfuran-2-yl)-1… | x-ray diffraction | A | — | — |
| 4R4O | Crystal structure of RPA70N in complex with 5-(4-((4-(5-carboxyfuran-2-yl)benzyl)carbamothioyl)pheny… | x-ray diffraction | A | — | — |
| 4R4O | Crystal structure of RPA70N in complex with 5-(4-((4-(5-carboxyfuran… | x-ray diffraction | A | — | — |
| 4R4Q | Crystal structure of RPA70N in complex with 5-(3-((N-(4-(5-carboxyfuran-2-yl)benzyl)acetamido)methyl… | x-ray diffraction | A | — | — |
| 4R4Q | Crystal structure of RPA70N in complex with 5-(3-((N-(4-(5… | x-ray diffraction | A | — | — |
| 4R4T | Crystal Structure of RPA70N in complex with 5-(4-((4-(5-carboxyfuran-2-yl)phenylthioamido)methyl)phe… | x-ray diffraction | A | — | — |
| 4R4T | Crystal structure of RPA70N in complex with 5-(4-((4-(5-carboxyfuran… | x-ray diffraction | A | — | — |
| 5E7N | Crystal structure of RPA70N in complex with VU0085636 | x-ray diffraction | A | — | — |
| 5EAY | Crystal structure of a DNA2 peptide in complex with rpa 70N | x-ray diffraction | A, B, C, D | — | — |
| 5N85 | Structure of RPA70N in complex with primpol (fragment 514-525) | x-ray diffraction | A | — | — |
| 5N8A | Structure of RPA70N in complex with primpol (fragment 480-560) | x-ray diffraction | A | — | — |
| 7XV0 | Crystal structure of RPA70N-BLMp1 fusion | x-ray diffraction | A | — | — |
| 7XV1 | Crystal structure of RPA70N-HelB fusion | x-ray diffraction | A | — | 1 (best 0.42) |
| 7XV4 | Crystal structure of RPA70N-ATRIP fusion | x-ray diffraction | A | — | — |
| 8RK2 | Human Replication protein A (RPA; trimeric core) - ssDNA complex | electron microscopy | A | — | 1 (best 0.81) |
| 9J1S | Human replication protein A: RPA70 subunit N-terminal domain | x-ray diffraction | A | — | — |
| P27694 | AlphaFold monomer V2.0 prediction for replication protein a 70 kda DNA-binding subunit (P27694) | — | — | — |
Elsewhere
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