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Ligand · MOV

MOV · AMG 510 (bound form)

MOV, AMG 510 (bound form) (C30 H32 F2 N6 O3, 562.6 g/mol), in the MolNFT structures on GenesisL1: bound in 3 records (3 PDB entries). Every binding site with its residues within 4.5 Å, the residues it binds most and the ligands found with…

Component
MOV
Formula
C30 H32 F2 N6 O3
Class
ligand
Structures
3
PDB entries
3

Binding sites

MOV in 3 structures; the first of them:

  • 8UDR · Structure of the P1B7 antibody bound to the Sotorasib-modified KRas G12C peptide… · MOV D301 · binds GLN72, ARG75, VAL76, CYS12, ALA54, ARG71, TYR73, ARG75 and 12 more
  • 8VR9 · Structure of a synthetic antibody in complex with a class I MHC presenting a… · MOV E301 · binds GLN155, LEU156, ALA158, TYR159, THR163, GLY10, ALA11, CYS12 and 20 more
  • 6OIM · Crystal structure of human KRAS G12C covalently bound to amg 510 · MOV A303 · binds VAL9, GLY10, CYS12, LYS16, PRO34, THR58, ALA59, GLY60 and 9 more

Residues it binds most

ALA 3, GLY 3, SER 1, TYR 3, GLN 3, THR 3, ARG 2, GLU 2, VAL 2, CYS 3 (residue and the binding sites it lines).

Found with

  • GDP · Guanosine-5'-diphosphate
  • MG · Magnesium ion

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