UniProt P03910
NADH-ubiquinone oxidoreductase chain 4 (P03910)
NADH-ubiquinone oxidoreductase chain 4 (UniProt P03910), EC 1.6.5.3, 7.1.1.2: 36 experimental structures on GenesisL1, 6 ligands bound, 121 pockets. Binding sites, pockets, druggability and 3D structures in GL1X.
- UniProt
- P03910
- Protein
- NADH-ubiquinone oxidoreductase chain 4
- EC
- 1.6.5.3, 7.1.1.2
- Experimental structures
- 36
- Predicted models
- 0
- Ligands
- 6
- Pockets
- 121 · 19 records with a druggable one
Structures
36 records of P03910 in the MolNFT archive: 36 experimental, 0 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 5LC5 | Structure of mammalian respiratory complex I, CLASS2 | electron microscopy | M | — | — |
| 5LDW | Structure of mammalian respiratory Complex I, class1 | electron microscopy | M | — | — |
| 5LDW | Structure of mammalian respiratory complex I, CLASS1 | electron microscopy | M | — | — |
| 5LDX | Structure of mammalian respiratory complex I, CLASS3. | electron microscopy | M | — | — |
| 5O31 | Mitochondrial complex I in the deactive state | electron microscopy | M | — | 5 (best 0.87) |
| 5O31 | Mitochondrial complex I in the deactive state | electron microscopy | M | — | — |
| 7DGQ | Activity optimized supercomplex state1 | electron microscopy | 4 | 3PE, CDL, PC1 | 3 (best 0.87) |
| 7DGZ | Activity optimized complex I (closed form) | electron microscopy | 4 | 3PE, CDL, PC1 | — |
| 7DH0 | Activity optimized complex I (open form) | electron microscopy | 4 | 3PE, CDL | — |
| 7DKF | Activity optimized supercomplex state4 | electron microscopy | 42 | 3PE, CDL | 3 (best 0.90) |
| 7QSD | Bovine complex I in the active state at 3.1 A | electron microscopy | M | 3PE, CDL, PC1 | 6 (best 0.87) |
| 7QSD | Bovine complex I in the active state at 3.1 a | electron microscopy | M | 3PE, CDL, PC1 | — |
| 7QSK | Bovine complex I in lipid nanodisc, active-Q10 | electron microscopy | M | 3PE, CDL, PC1 | — |
| 7QSL | Bovine complex I in lipid nanodisc, active-apo | electron microscopy | M | 3PE, CDL, PC1 | — |
| 7QSM | Bovine complex I in lipid nanodisc, Deactive-ligand (composite) | electron microscopy | M | 3PE, CDL, PC1 | 6 (best 0.85) |
| 7QSM | Bovine complex I in lipid nanodisc, deactive-ligand (composite) | electron microscopy | M | 3PE, CDL, PC1 | — |
| 7QSN | Bovine complex I in lipid nanodisc, deactive-apo | electron microscopy | M | 3PE, CDL, PC1 | — |
| 7QSO | Bovine complex I in lipid nanodisc, State 3 (Slack) | electron microscopy | M | 3PE, CDL, U10, PC1 | — |
| 7QSO | Bovine complex I in lipid nanodisc, state 3 (slack) | electron microscopy | M | 3PE, CDL, U10, PC1 | — |
| 7R41 | Bovine complex I in the presence of IM1761092, active class i (Composite map) | electron microscopy | M | 3PE, CDL, PC1 | 8 (best 0.86) |
| 7R43 | Bovine complex I in the presence of IM1761092, active class iii (Composite map) | electron microscopy | M | 3PE, CDL, PC1 | — |
| 7R44 | Bovine complex I in the presence of IM1761092, active class iv (Composite map) | electron microscopy | M | 3PE, CDL, PC1 | 8 (best 0.86) |
| 7R45 | Bovine complex I in the presence of IM1761092, deactive class i (Composite map) | electron microscopy | M | 3PE, CDL, PC1 | 7 (best 0.86) |
| 7R46 | Bovine complex I in the presence of IM1761092, deactive class ii (Composite map) | electron microscopy | M | 3PE, CDL, PC1 | 6 (best 0.85) |
| 7R47 | Bovine complex I in the presence of IM1761092, deactive class iii (Composite map) | electron microscopy | M | 3PE, CDL, PC1 | — |
| 7R48 | Bovine complex I in the presence of IM1761092, deactive class iv (Composite map) | electron microscopy | M | 3PE, CDL, PC1 | 7 (best 0.85) |
| 7R4C | Bovine complex I in the presence of IM1761092, deactive class v (Composite map) | electron microscopy | M | 3PE, CDL, PC1 | 7 (best 0.85) |
| 7R4G | Bovine complex I in the presence of IM1761092, slack class ii (Composite map) | electron microscopy | M | 3PE, CDL, PC1 | 8 (best 0.86) |
| 8Q0A | Inward-facing, closed proteoliposome complex I at 3.1 A. Initially purified in DDM. | electron microscopy | M | CDL, 3PE, PC1, ZN, PLC | 7 (best 0.87) |
| 8Q0J | Inward-facing, slack proteoliposome complex I at 3.8 A. Initially purified in DDM. | electron microscopy | M | 3PE, CDL | 7 (best 0.86) |
| 8Q0M | Outward-facing, closed proteoliposome complex I at 3.1 A. Initially purified in DDM. | electron microscopy | M | 3PE, PC1, CDL, ZN, PLC | 5 (best 0.86) |
| 8Q1P | Inward-facing, open2 proteoliposome complex I at 2.9 A, after deactivation treatment. Initially… | electron microscopy | M | CDL, 3PE, PC1, ZN, PLC | 6 (best 0.87) |
| 8Q1U | Inward-facing, open1 proteoliposome complex I at 3.3 A, after deactivation treatment. Initially… | electron microscopy | M | CDL, 3PE, PC1, ZN | 7 (best 0.86) |
| 8Q1Y | Outward-facing, open2 proteoliposome complex I at 2.6 A, after deactivation treatment. Initially… | electron microscopy | M | PC1, 3PE, ZN, CDL, PLC | 8 (best 0.88) |
| 8Q4A | Outward-facing, open1 proteoliposome complex I at 2.6 A. Initially purified in LMNG. | electron microscopy | M | CDL, PC1, 3PE, ZN, PLC | 7 (best 0.87) |
| P03910 | AlphaFold monomer V2.0 prediction for NADH-ubiquinone oxidoreductase chain 4 (P03910) | — | — | — |
Ligands
Elsewhere
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