UniProt P03367
Protease (P03367)
Protease (UniProt P03367), EC 2.7.7.-, 2.7.7.49: 371 experimental structures on GenesisL1, 44 ligands bound, 51 pockets. Binding sites, pockets, druggability and 3D structures in GL1X.
- UniProt
- P03367
- Protein
- Protease
- EC
- 2.7.7.-, 2.7.7.49, 2.7.7.7, 3.1.-.-, 3.1.13.2, 3.1.26.13, 3.4.23.16
- Experimental structures
- 371
- Predicted models
- 0
- Ligands
- 44
- Pockets
- 51 · 43 records with a druggable one
Structures
371 records of P03367 in the MolNFT archive: 371 experimental, 0 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 1A8K | Crystallographic analysis of human immunodeficiency virus 1 protease with an analog of the… | x-ray diffraction | A, B, D, E | — | — |
| 1A8K | Crystallographic analysis of human immunodeficiency virus 1 protease with an analog of the… | x-ray diffraction | A, B, D, E | — | — |
| 1A94 | Structural basis for specificity of retroviral proteases | x-ray diffraction | A, B, D, E | — | — |
| 1A94 | Structural basis for specificity of retroviral proteases | x-ray diffraction | A, B, D, E | — | — |
| 1D4S | HIV-1 protease V82F/I84V double MUTANT/TIPRANAVIR complex | x-ray diffraction | A, B | — | — |
| 1D4S | HIV-1 protease V82F/I84V double MUTANT/TIPRANAVIR complex | x-ray diffraction | A, B | — | — |
| 1D4Y | HIV-1 protease triple MUTANT/TIPRANAVIR complex | x-ray diffraction | A, B | — | — |
| 1D4Y | HIV-1 protease triple MUTANT/TIPRANAVIR complex | x-ray diffraction | A, B | — | — |
| 1DAZ | Structural and kinetic analysis of drug resistant mutants of HIV-1 protease | x-ray diffraction | C, D | — | — |
| 1DAZ | Structural and kinetic analysis of drug resistant mutants of HIV-1 protease | x-ray diffraction | C, D | — | — |
| 1DIF | HIV-1 protease in complex with a difluoroketone containing inhibitor A79285 | x-ray diffraction | A, B | — | — |
| 1DIF | HIV-1 protease in complex with a difluoroketone containing inhibitor A79285 | x-ray diffraction | A, B | — | — |
| 1FQX | Crystal structure of the complex of HIV-1 protease with a peptidomimetic inhibitor | x-ray diffraction | A, B | — | — |
| 1FQX | Crystal structure of the complex of HIV-1 protease with a peptidomimetic inhibitor | x-ray diffraction | A, B | — | — |
| 1HHP | The three-dimensional structure of the aspartyl protease from the HIV-1 isolate bru | x-ray diffraction | A | — | — |
| 1HHP | The three-dimensional structure of the aspartyl protease from the HIV- 1 isolate bru | x-ray diffraction | A | — | — |
| 1HNI | Structure of HIV-1 reverse transcriptase in a complex with the nonnucleoside inhibitor alpha-apa R… | x-ray diffraction | B | — | — |
| 1HNI | Structure of HIV-1 reverse transcriptase in a complex with the nonnucleoside inhibitor alpha-apa R… | x-ray diffraction | B | — | — |
| 1HPO | HIV-1 protease triple MUTANT/U103265 complex | x-ray diffraction | A, B | — | — |
| 1HPO | HIV-1 protease triple MUTANT/U103265 complex | x-ray diffraction | A, B | — | — |
| 1HPX | HIV-1 protease complexed with the inhibitor kni-272 | x-ray diffraction | A, B | — | — |
| 1HPX | HIV-1 protease complexed with the inhibitor kni-272 | x-ray diffraction | A, B | — | — |
| 1HSG | Crystal structure at 1.9 ångströms resolution of human immunodeficiency virus (HIV) II protease… | x-ray diffraction | A, B | — | — |
| 1HSG | Crystal structure at 1.9 ångströms resolution of human immunodeficiency virus (HIV) II protease… | x-ray diffraction | A, B | — | — |
| 1HVL | Influence of stereochemistry on activity and binding modes for C2 symmetry-based diol inhibitors of… | x-ray diffraction | A, B | — | — |
| 1HVL | Influence of stereochemistry on activity and binding modes for C2 symmetry-based diol inhibitors of… | x-ray diffraction | A, B | — | — |
| 1IIQ | Crystal structure of HIV-1 protease complexed with a hydroxyethylamine peptidomimetic inhibitor | x-ray diffraction | A, B | — | — |
| 1IIQ | Crystal structure of HIV-1 protease complexed with a hydroxyethylamine peptidomimetic inhibitor | x-ray diffraction | A, B | — | — |
| 1LZQ | Crystal structure of the complex of mutant HIV-1 protease (A71V, V82T, I84V) with an ethylenamine… | x-ray diffraction | A, B | — | — |
| 1LZQ | Crystal structure of the complex of mutant HIV-1 protease (A71V, V82T, I84V) with an ethylenamine… | x-ray diffraction | A, B | — | — |
| 1M0B | HIV-1 protease in complex with an ethyleneamine inhibitor | x-ray diffraction | A, B | — | — |
| 1M0B | HIV-1 protease in complex with an ethyleneamine inhibitor | x-ray diffraction | A, B | — | — |
| 1MRW | Structure of HIV protease (Mutant Q7K L33I L63I) complexed with KNI-577 | x-ray diffraction | A, B | — | — |
| 1MRW | Structure of HIV protease (mutant Q7K L33I L63I) complexed with kni- 577 | x-ray diffraction | A, B | — | — |
| 1MRX | Structure of HIV protease (Mutant Q7K L33I L63I V82F I84V ) complexed with KNI-577 | x-ray diffraction | A, B | — | — |
| 1MRX | Structure of HIV protease (mutant Q7K L33I L63I V82F I84V ) complexed with kni-577 | x-ray diffraction | A, B | — | — |
| 1MSM | The HIV protease (mutant Q7K L33I L63I) complexed with KNI-764 (an inhibitor) | x-ray diffraction | A, B | — | — |
| 1MSM | The HIV protease (mutant Q7K L33I L63I) complexed with kni-764 (an inhibitor) | x-ray diffraction | A, B | — | — |
| 1MSN | The HIV protease (mutant Q7K L33I L63I V82F I84V) complexed with KNI-764 (an inhibitor) | x-ray diffraction | A, B | — | — |
| 1MSN | The HIV protease (mutant Q7K L33I L63I V82F I84V) complexed with kni- 764 (an inhibitor) | x-ray diffraction | A, B | — | — |
| 1NH0 | 1.03 A structure of HIV-1 protease: inhibitor binding inside and outside the active site | x-ray diffraction | A, B | — | — |
| 1NH0 | 1.03 a structure of HIV-1 protease: inhibitor binding inside and outside the active site | x-ray diffraction | A, B | — | — |
| 1RL8 | Crystal structure of the complex of resistant strain of hiv-1 protease(v82a mutant) with ritonavir | x-ray diffraction | A, B | — | — |
| 1RL8 | Crystal structure of the complex of resistant strain of HIV-1 PROTEASE(V82A mutant) with ritonavir | x-ray diffraction | A, B | — | — |
| 1SDT | Crystal structures of HIV protease V82A and L90M mutants reveal changes in indinavir binding site. | x-ray diffraction | A, B | — | — |
| 1SDT | Crystal structures of HIV protease V82A and L90M mutants reveal changes in indinavir binding site. | x-ray diffraction | A, B | — | — |
| 1SDU | Crystal structures of HIV protease V82A and L90M mutants reveal changes in indinavir binding site. | x-ray diffraction | A, B | — | — |
| 1SDU | Crystal structures of HIV protease V82A and L90M mutants reveal changes in indinavir binding site. | x-ray diffraction | A, B | — | — |
| 1SDV | Crystal structures of HIV protease V82A and L90M mutants reveal changes in indinavir binding site. | x-ray diffraction | A, B | — | — |
| 1SDV | Crystal structures of HIV protease V82A and L90M mutants reveal changes in indinavir binding site. | x-ray diffraction | A, B | — | — |
| 1SGU | Comparing the Accumulation of Active Site and Non-active Site Mutations in the HIV-1 Protease | x-ray diffraction | A, B | — | — |
| 1SGU | Comparing the accumulation of active site and non-active site mutations in the HIV-1 protease | x-ray diffraction | A, B | — | — |
| 1SH9 | Comparing the Accumulation of Active Site and Non-active Site Mutations in the HIV-1 Protease | x-ray diffraction | A, B | — | — |
| 1SH9 | Comparing the accumulation of active site and non-active site mutations in the HIV-1 protease | x-ray diffraction | A, B | — | — |
| 1SP5 | Crystal structure of HIV-1 protease complexed with a product of autoproteolysis | x-ray diffraction | A, B, I | — | — |
| 1SP5 | Crystal structure of HIV-1 protease complexed with a product of autoproteolysis | x-ray diffraction | A, B, I | — | — |
| 1U8G | Crystal structure of a HIV-1 Protease in complex with peptidomimetic inhibitor KI2-PHE-GLU-GLU-NH2 | x-ray diffraction | A, B | — | — |
| 1U8G | Crystal structure of a HIV-1 protease in complex with peptidomimetic inhibitor KI2-phe-glu-glu-NH2 | x-ray diffraction | A, B | — | — |
| 1UPJ | HIV-1 protease complex with U095438 [3-[1-(4-bromophenyl) isobutyl]-4-hydroxycoumarin | x-ray diffraction | A | — | — |
| 1UPJ | HIV-1 protease complex with U095438 [3-[1-(4-bromophenyl) isobutyl]-4- hydroxycoumarin | x-ray diffraction | A | — | — |
311 records more on the page itself.
Ligands
- SO4 · Sulfate ion · in 62 records
- 017 · (3r,3as,6ar)-hexahydrofuro[2,3-b]furan-3-yl(1s,2r)-3-[[(4-aminophenyl)sulfonyl](isobutyl)amino]-1-benzyl-2-hydroxypropylcarbamate · in 7 records
- 478 · {3-[(4-amino-benzenesulfonyl)-isobutyl-amino]-1-benzyl-2-hydroxy-propyl}-carbamic acid tetrahydro-furan-3-yl ester · in 6 records
- PO4 · Phosphate ion · in 4 records
- YUA · (3R,3aS,6aR)-hexahydrofuro[2,3-b]furan-3-yl [(2S,3R)-4-{(2-ethylbutyl)[(1S)-1-hydroxy-2,3-dihydro-1H-indene-5-sulfonyl]amino}-3-hydroxy-1-phenylbutan-2-yl]carbamate · in 4 records
- YWP · Diethyl [(4-{(2S,3R)-2-[({[(3r,3as,6ar)-hexahydrofuro[2,3-b]furan-3-yl]oxy}carbonyl)amino]-3-hydroxy-4-[{4-[(1R)-1-hydroxyethyl]benzene-1-sulfonyl}(2-methylpropyl)amino]butyl}phenoxy) methyl]phosphonate · in 4 records
- YUD · (3R,3aS,6aR)-hexahydrofuro[2,3-b]furan-3-yl [(2S,3R)-3-hydroxy-4-{[(1S)-1-hydroxy-2,3-dihydro-1H-indene-5-sulfonyl][(2S)-2-methylbutyl]amino}-1-phenylbutan-2-yl]carbamate · in 3 records
- YUJ · (3R,3aS,6aR)-hexahydrofuro[2,3-b]furan-3-yl [(2S,3R)-3-hydroxy-4-{[(1S)-1-hydroxy-2,3-dihydro-1H-indene-5-sulfonyl](2-methylpropyl)amino}-1-phenylbutan-2-yl]carbamate · in 3 records
- YWM · Diethyl [(4-{(2S,3R)-2-[({[(3r,3as,6ar)-hexahydrofuro[2,3-b]furan-3-yl]oxy}carbonyl)amino]-3-hydroxy-4-[{4-[(1S)-1-hydroxyethyl]benzene-1-sulfonyl}(2-methylpropyl)amino]butyl}phenoxy) methyl]phosphonate · in 3 records
- YWS · Diethyl ({4-[(2S,3R)-2-[({[(3r,3as,6ar)-hexahydrofuro[2,3-b]furan-3-yl]oxy}carbonyl)amino]-3-hydroxy-4-({4-[(1S)-1-hydroxyethyl]benzene-1-sulfonyl}[(2s)-2-methylbutyl]amino) butyl]phenoxy}methyl)phosphonate · in 3 records
- 065 · (3r,3as,6ar)-hexahydrofuro[2,3-b]furan-3-yl(2s,3r)-3-hydroxy-4-(N-isobutylbenzo[d][1,3]dioxole-5-sulfonamido)-1-phenylbutan-2-ylcarbamate · in 2 records
- CA · Calcium ion · in 2 records
- DJR · (3r,3as,6ar)-hexahydrofuro[2,3-b]furan-3-yl [(1S,2R)-1-benzyl-2-hydroxy-3-{isobutyl[(4-methoxyphenyl) sulfonyl]amino}propyl]carbamate · in 2 records
- EFZ · (-)-6-chloro-4-cyclopropylethynyl-4-trifluoromethyl-1, 4-dihydro-2H-3,1-benzoxazin-2-one · in 2 records
- KGQ · Diethyl ({4-[(2S,3R)-2-({[(3r,3as,6ar)-hexahydrofuro[2, 3-b]furan-3-yloxy]carbonyl}amino)-3-hydroxy-4-{isobutyl[(4-methoxyphenyl) sulfonyl]amino}butyl]phenoxy}methyl)phosphonate · in 2 records
- NF7 · (3R,3aS,6aR)-hexahydrofuro[2,3-b]furan-3-yl {(2S,3R)-4-[({4-[(1R)-1,2-dihydroxyethyl]phenyl}sulfonyl)(2-methylpropyl)amino]-3-hydroxy-1-phenylbutan-2-yl}carbamate · in 2 records
- NJ1 · (3R,3aS,6aR)-hexahydrofuro[2,3-b]furan-3-yl {(2S,3R)-4-[({4-[(1R)-1,2-dihydroxyethyl]phenyl}sulfonyl)(2-ethylbutyl)amino]-3-hydroxy-1-phenylbutan-2-yl}carbamate · in 2 records
- NJG · (3R,3aS,6aR)-hexahydrofuro[2,3-b]furan-3-yl [(2S,3R)-4-{({4-[(1R)-1,2-dihydroxyethyl]phenyl}sulfonyl)[(2S)-2-methylbutyl]amino}-3-hydroxy-1-phenylbutan-2-yl]carbamate · in 2 records
- NJM · (3R,3aS,6aR)-hexahydrofuro[2,3-b]furan-3-yl {(2S,3R)-3-hydroxy-4-[{[4-(hydroxymethyl)phenyl]sulfonyl}(2-methylpropyl)amino]-1-phenylbutan-2-yl}carbamate · in 2 records
- TK7 · Diethyl [(4-{(2S,3R)-4-{[(4-aminophenyl)sulfonyl](2-ethylbutyl)amino}-2-[({[(3r,3as,6ar)-hexahydrofuro[2, 3-b]furan-3-yl]oxy}carbonyl)amino]-3-hydroxybutyl}phenoxy)methyl]phosphonate · in 2 records
- XUM · Diethyl [(4-{(2S,3R)-4-{[(2H-1,3-benzodioxol-5-yl) sulfonyl](2-methylpropyl)amino}-2-[({[(3r,3as,6ar)-hexahydrofuro[2,3-b]furan-3-yl]oxy}carbonyl)amino]-3-hydroxybutyl}phenoxy)methyl]phosphonate · in 2 records
- XUS · diethyl [(4-{(2S,3R)-4-{[(4-aminophenyl)sulfonyl][(2S)-2-methylbutyl]amino}-2-[({[(3R,3aS,6aR)-hexahydrofuro[2,3-b]furan-3-yl]oxy}carbonyl)amino]-3-hydroxybutyl}phenoxy)methyl]phosphonate · in 2 records
- XUV · diethyl ({4-[(2S,3R)-2-[({[(3R,3aS,6aR)-hexahydrofuro[2,3-b]furan-3-yl]oxy}carbonyl)amino]-3-hydroxy-4-{[(4-methoxyphenyl)sulfonyl][(2S)-2-methylbutyl]amino}butyl]phenoxy}methyl)phosphonate · in 2 records
- XVJ · Diethyl [(4-{(2S,3R)-4-{[(1,3-benzothiazol-6-yl) sulfonyl][(2s)-2-methylbutyl]amino}-2-[({[(3r,3as, 6AR)-hexahydrofuro[2,3-b]furan-3-yl]oxy}carbonyl) amino]-3-hydroxybutyl}phenoxy)methyl]phosphonate · in 2 records
- XVP · diethyl ({4-[(2S,3R)-2-[({[(3R,3aS,6aR)-hexahydrofuro[2,3-b]furan-3-yl]oxy}carbonyl)amino]-3-hydroxy-4-({[4-(hydroxymethyl)phenyl]sulfonyl}[(2S)-2-methylbutyl]amino)butyl]phenoxy}methyl)phosphonate · in 2 records
- XVS · diethyl [(4-{(2S,3R)-4-{(2-ethylbutyl)[(4-methoxyphenyl)sulfonyl]amino}-2-[({[(3R,3aS,6aR)-hexahydrofuro[2,3-b]furan-3-yl]oxy}carbonyl)amino]-3-hydroxybutyl}phenoxy)methyl]phosphonate · in 2 records
- XVV · Diethyl [(4-{(2S,3R)-4-{[(1,3-benzothiazol-6-yl) sulfonyl](2-ethylbutyl)amino}-2-[({[(3r,3as,6ar)-hexahydrofuro[2,3-b]furan-3-yl]oxy}carbonyl)amino]-3-hydroxybutyl}phenoxy)methyl]phosphonate · in 2 records
- XVY · Diethyl [(4-{(2S,3R)-4-[(2-ethylbutyl){[4-(hydroxymethyl)phenyl]sulfonyl}amino]-2-[({[(3r,3as, 6AR)-hexahydrofuro[2,3-b]furan-3-yl]oxy}carbonyl) amino]-3-hydroxybutyl}phenoxy)methyl]phosphonate · in 2 records
- XW4 · Diethyl [(4-{(2S,3R)-4-{[(2H-1,3-benzodioxol-5-yl) sulfonyl](2-ethylbutyl)amino}-2-[({[(3r,3as,6ar)-hexahydrofuro[2,3-b]furan-3-yl]oxy}carbonyl)amino]-3-hydroxybutyl}phenoxy)methyl]phosphonate · in 2 records
- A61 · (3R,3aS,6aR)-hexahydrofuro[2,3-b]furan-3-yl {(1S,2R)-3-[(1,3-benzothiazol-6-ylsulfonyl)(2-ethylbutyl)amino]-1-benzyl-2-hydroxypropyl}carbamate · in 1 record
Elsewhere
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