3TL · benzyl [(1S,4S,7S,8R,9R,10S,13S,16S)-7,10-dibenzyl-8,9-dihydroxy-1,16-dimethyl-4,13-bis(1-methylethyl)-2,5,12,15,18-pentaoxo-20-phenyl-19-oxa-3,6,11,14,17-pentaazaicos-1-yl]carbamate

Binding sites

3TL in 7 structures; the first of them:

• 5FIV · Structural studies of HIV and fiv proteases complexed with an efficient inhibitor of fiv… · 3TL A201 · binds ASP30, GLY32, ALA33, ASP34, ILE35, ILE37, GLN54, ASN55 and 5 more
• 5VEA · HIV Protease (PR) with TL-3 in active site and 4-methylbenzene-1,2-diamine in exosite · 3TL A101 · binds ASP25, GLY27, ALA28, ASP29, ASP30, VAL32, LYS45, MET46 and 6 more
• 6FIV · Structural studies of HIV and fiv proteases complexed with an efficient inhibitor of fiv… · 3TL A201 · binds ASP30, GLY32, ALA33, ASP34, ILE35, ILE37, GLN54, ASN55 and 5 more
• 5VCK · HIV protease (pr) with tl-3 in the active site and (Z)-N-(thiazol-2… · 3TL A100 · binds ASP25, GLY27, ALA28, ASP29, MET46, ILE47, GLY48, GLY49 and 17 more
• 5VEA · HIV protease (pr) with tl-3 in active site and 4-methylbenzene-1,2- diamine in exosite · 3TL A101 · binds ASP25, GLY27, ALA28, ASP29, ASP30, MET46, ILE47, GLY48 and 3 more
• 5W5W · HIV protease (pr) in open form with MG2+ in active site and hive-9 in eye site · 3TL A101 · binds ARG8, LEU23, ASP25, GLY27, ALA28, ASP29, ASP30, VAL32 and 23 more
• 6FIV · Structural studies of HIV and fiv proteases complexed with an efficient inhibitor of fiv… · 3TL A201 · binds ASP30, GLY32, ALA33, ASP34, ILE35, ILE37, GLN54, ASN55 and 5 more

Residues it binds most

ILE 7, GLY 7, ASP 7, ALA 7, MET 7, VAL 5, LEU 4, PRO 2, ASN 3, GLN 3 (residue and the binding sites it lines).

Found with

• DMS · Dimethyl sulfoxide
• 9AY · 4-methylbenzene-1,2-diamine
• SO4 · Sulfate ion
• 7GC · 4-methyl-N-(thiazol-2-ylcarbamoyl)benzenesulfonamide
• HV9 · 4-methyl-N-({1-[4-(trifluoromethyl)pyrimidin-2-yl]piperidin-4-yl}carbamoyl)benzene-1-sulfonamide