UniProt P00883
Fructose-bisphosphate aldolase A (P00883)
Fructose-bisphosphate aldolase A (UniProt P00883), EC 4.1.2.13: 70 experimental structures and 1 predicted model on GenesisL1, 6 ligands bound, 73 pockets. Binding sites, druggability and experiment against prediction (TM-score)…
- UniProt
- P00883
- Protein
- Fructose-bisphosphate aldolase A
- EC
- 4.1.2.13
- Experimental structures
- 70
- Predicted models
- 1
- Ligands
- 6
- Pockets
- 73 · 5 records with a druggable one
Structures
71 records of P00883 in the MolNFT archive: 70 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 1ADO | Fructose 1,6-bisphosphate aldolase from rabbit muscle | x-ray diffraction | A, B, C, D | — | — |
| 1ADO | Fructose 1,6-bisphosphate aldolase from rabbit muscle | x-ray diffraction | A, B, C, D | — | — |
| 1EWD | Fructose 1,6-bisphosphate aldolase from rabbit muscle | x-ray diffraction | A, B, C, D | — | — |
| 1EWD | Fructose 1,6-bisphosphate aldolase from rabbit muscle | x-ray diffraction | A, B, C, D | — | — |
| 1EWE | Fructose 1,6-Bisphosphate Aldolase from Rabbit Muscle | x-ray diffraction | A, B, C, D | — | — |
| 1EWE | Fructose 1,6-bisphosphate aldolase from rabbit muscle | x-ray diffraction | A, B, C, D | — | — |
| 1EX5 | Fructose 1,6-bisphosphate aldolase from rabbit muscle | x-ray diffraction | A, B, C, D | — | — |
| 1EX5 | Fructose 1,6-bisphosphate aldolase from rabbit muscle | x-ray diffraction | A, B, C, D | — | — |
| 1J4E | Fructose-1,6-bisphosphate aldolase covalently bound to the substrate dihydroxyacetone phosphate | x-ray diffraction | A, B, C, D | — | — |
| 1J4E | Fructose-1,6-bisphosphate aldolase covalently bound to the substrate dihydroxyacetone phosphate | x-ray diffraction | A, B, C, D | — | — |
| 1ZAH | Fructose-1,6-bisphosphate aldolase from rabbit muscle | x-ray diffraction | A, B, C, D | — | — |
| 1ZAH | Fructose-1,6-bisphosphate aldolase from rabbit muscle | x-ray diffraction | A, B, C, D | — | — |
| 1ZAI | Fructose-1,6-bisphosphate Schiff base intermediate in FBP aldolase from rabbit muscle | x-ray diffraction | A, B, C, D | — | — |
| 1ZAI | Fructose-1,6-bisphosphate schiff base intermediate in fbp aldolase from rabbit muscle | x-ray diffraction | A, B, C, D | — | — |
| 1ZAJ | Fructose-1,6-bisphosphate aldolase from rabbit muscle in complex with mannitol-1,6-bisphosphate, a… | x-ray diffraction | A, B, C, D | — | — |
| 1ZAJ | Fructose-1,6-bisphosphate aldolase from rabbit muscle in complex with mannitol-1,6-bisphosphate, a… | x-ray diffraction | A, B, C, D | — | — |
| 1ZAL | Fructose-1,6-bisphosphate aldolase from rabbit muscle in complex with partially disordered… | x-ray diffraction | A, B, C, D | — | — |
| 1ZAL | Fructose-1,6-bisphosphate aldolase from rabbit muscle in complex with partially disordered… | x-ray diffraction | A, B, C, D | — | — |
| 2OT0 | Fructose-1,6-bisphosphate aldolase from rabbit muscle in complex with a C-terminal peptide of… | x-ray diffraction | A, B, C, D | — | — |
| 2OT0 | Fructose-1,6-bisphosphate aldolase from rabbit muscle in complex with a C-terminal peptide of… | x-ray diffraction | A, B, C, D | — | — |
| 2OT1 | Fructose-1,6-bisphosphate aldolase from rabbit muscle in complex with naphthol AS-E phosphate, a… | x-ray diffraction | A, B, C, D | — | — |
| 2OT1 | Fructose-1,6-bisphosphate aldolase from rabbit muscle in complex with naphthol as-E phosphate, a… | x-ray diffraction | A, B, C, D | — | — |
| 2QUT | Dihydroxyacetone phosphate enamine intermediate in fructose-1,6-bisphosphate aldolase from rabbit… | x-ray diffraction | A, B, C, D | — | — |
| 2QUT | Dihydroxyacetone phosphate enamine intermediate in fructose- 1,6-bisphosphate aldolase from rabbit… | x-ray diffraction | A, B, C, D | — | — |
| 2QUU | Dihydroxyacetone phosphate Schiff base intermediate in mutant fructose-1,6-bisphosphate aldolase… | x-ray diffraction | A, B, C, D | — | — |
| 2QUU | Dihydroxyacetone phosphate schiff base intermediate in mutant fructose-1,6-bisphosphate aldolase… | x-ray diffraction | A, B, C, D | — | — |
| 2QUV | Phosphate ions in fructose-1,6-bisphosphate aldolase from rabbit muscle | x-ray diffraction | A, B, C, D | — | — |
| 2QUV | Phosphate ions in fructose-1,6-bisphosphate aldolase from rabbit muscle | x-ray diffraction | A, B, C, D | — | — |
| 3B8D | Fructose 1,6-bisphosphate aldolase from rabbit muscle | x-ray diffraction | A, B, C, D | — | — |
| 3B8D | Fructose 1,6-bisphosphate aldolase from rabbit muscle | x-ray diffraction | A, B, C, D | — | — |
| 3BV4 | Crystal structure of a rabbit muscle fructose-1,6-bisphosphate aldolase A dimer variant | x-ray diffraction | A | — | — |
| 3BV4 | Crystal structure of a rabbit muscle fructose-1,6-bisphosphate aldolase a dimer variant | x-ray diffraction | A | — | — |
| 3DFN | D33N mutant fructose-1,6-bisphosphate aldolase from rabbit muscle | x-ray diffraction | A, B, C, D | — | — |
| 3DFN | D33N mutant fructose-1,6-bisphosphate aldolase from rabbit muscle | x-ray diffraction | A, B, C, D | — | — |
| 3DFO | Dihydroxyacetone phosphate Schiff base and enamine intermediates in D33N mutant… | x-ray diffraction | A, B, C, D | — | — |
| 3DFO | Dihydroxyacetone phosphate schiff base and enamine intermediates in D33N mutant… | x-ray diffraction | A, B, C, D | — | — |
| 3DFP | Phosphate ions in D33N mutant fructose-1,6-bisphosphate aldolase from rabbit muscle | x-ray diffraction | A, B, C, D | — | — |
| 3DFP | Phosphate ions in D33N mutant fructose-1,6-bisphosphate aldolase from rabbit muscle | x-ray diffraction | A, B, C, D | — | — |
| 3DFQ | D33S mutant fructose-1,6-bisphosphate aldolase from rabbit muscle | x-ray diffraction | A, B, C, D | — | — |
| 3DFQ | D33S mutant fructose-1,6-bisphosphate aldolase from rabbit muscle | x-ray diffraction | A, B, C, D | — | — |
| 3DFS | Dihydroxyacetone phosphate Schiff base intermediate in D33S mutant fructose-1,6-bisphosphate… | x-ray diffraction | A, B, C, D | — | — |
| 3DFS | Dihydroxyacetone phosphate schiff base intermediate in D33S mutant fructose-1,6-bisphosphate… | x-ray diffraction | A, B, C, D | — | — |
| 3DFT | Phosphate ions in D33S mutant fructose-1,6-bisphosphate aldolase from rabbit muscle | x-ray diffraction | A, B, C, D | — | — |
| 3DFT | Phosphate ions in D33S mutant fructose-1,6-bisphosphate aldolase from rabbit muscle | x-ray diffraction | A, B, C, D | — | — |
| 3LGE | Crystal structure of rabbit muscle aldolase-SNX9 LC4 complex | x-ray diffraction | A, B, C, D | — | — |
| 3LGE | Crystal structure of rabbit muscle aldolase-SNX9 LC4 complex | x-ray diffraction | A, B, C, D | — | — |
| 3TU9 | Crystal structure of rabbit muscle aldolase bound with 5-O-methyl mannitol 1,6-phosphate | x-ray diffraction | A, B, C, D | — | — |
| 3TU9 | Crystal structure of rabbit muscle aldolase bound with 5-O-methyl mannitol 1,6-phosphate | x-ray diffraction | A, B, C, D | — | — |
| 5F4X | Fructose-1,6-bisphosphate aldolase K229M mutant from rabbit muscle | x-ray diffraction | A, B, C, D | — | — |
| 5F4X | Fructose-1,6-bisphosphate aldolase K229M mutant from rabbit muscle | x-ray diffraction | A, B, C, D | — | — |
| 5TLE | Fructose-1,6-bisphosphate aldolase from rabbit muscle in complex with the inhibitor… | x-ray diffraction | A, B, C, D | RD1 | 16 (best 0.89) |
| 5TLE | Fructose-1,6-bisphosphate aldolase from rabbit muscle in complex with the inhibitor… | x-ray diffraction | A, B, C, D | RD1 | — |
| 5TLH | Fructose-1,6-bisphosphate aldolase from rabbit muscle in complex with the inhibitor 2-naphthol… | x-ray diffraction | A, B, C, D | RD2, MDN | — |
| 5TLW | Fructose-1,6-bisphosphate aldolase from rabbit muscle in complex with the inhibitor… | x-ray diffraction | A, B, C, D | RD3 | — |
| 5TLZ | Fructose-1,6-bisphosphate aldolase from rabbit muscle in complex with the inhibitor naphthalene… | x-ray diffraction | A, B, C, D | N26 | — |
| 5VY5 | Rabbit muscle aldolase using 200KEV | electron microscopy | B, A, C, D | — | — |
| 6ALD | Rabbit muscle aldolase A/FRUCTOSE-1,6-bisphosphate complex | x-ray diffraction | A, B, C, D | 2FP | — |
| 6MWQ | Single particle cryoem structure of a darpin-aldolase platform in complex with GFP | electron microscopy | A, B, C, D | — | — |
| 6V20 | Rabbit muscle aldolase determined using single-particle cryo-EM at 200 keV | electron microscopy | A, B, C, D | — | — |
| 6V20 | Rabbit muscle aldolase determined using single-particle cryo-EM at 200 kev | electron microscopy | A, B, C, D | — | — |
11 records more on the page itself.
Ligands
- RD1 · {[6-(phosphonooxy)naphthalen-2-yl]methylene}bis(phosphonic acid) · in 2 records
- 2FP · 1,6-fructose diphosphate (linear form) · in 1 record
- MDN · Methylenediphosphonic acid · in 1 record
- N26 · Naphthalene-2,6-diyl bis[dihydrogen (phosphate)] · in 1 record
- RD2 · [(6-hydroxynaphthalen-2-yl)methylene]bis(phosphonic acid) · in 1 record
- RD3 · {[4-(phosphonooxy)phenyl]methylene}bis(phosphonic acid) · in 1 record
Experiment against prediction
- 5TLH chain D against the predicted model P00883: TM-score 1.00, RMSD 0.24 Å
- 3TU9 chain D against the predicted model P00883: TM-score 1.00, RMSD 0.25 Å
- 3TU9 chain D against the predicted model P00883: TM-score 1.00, RMSD 0.25 Å
- 1J4E chain C against the predicted model P00883: TM-score 1.00, RMSD 0.26 Å
- 1J4E chain C against the predicted model P00883: TM-score 1.00, RMSD 0.26 Å
- 1J4E chain B against the predicted model P00883: TM-score 1.00, RMSD 0.26 Å
- 1J4E chain B against the predicted model P00883: TM-score 1.00, RMSD 0.26 Å
- 1J4E chain A against the predicted model P00883: TM-score 1.00, RMSD 0.26 Å
- 1J4E chain A against the predicted model P00883: TM-score 1.00, RMSD 0.26 Å
- 1J4E chain D against the predicted model P00883: TM-score 1.00, RMSD 0.26 Å
Elsewhere
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