MolNFT v1 · #5898 · protein

Fructose 1,6-bisphosphate aldolase from rabbit muscle

1EWD: “Fructose 1,6-bisphosphate aldolase from rabbit muscle”. X-ray diffraction, 15 pockets (best druggability 0.88). MolNFT v1 #5898 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 1EWD
Type: protein
Length: 1,452 residues
Chains: 4
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Fructose 1,6-bisphosphate aldolase
EC: 4.1.2.13
UniProt: P00883
Pockets: 15 · best druggability 0.88

Structure

x-ray diffraction · 1 distinct chain · 45% helix, 15% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A, B, C, D	Fructose 1,6-bisphosphate aldolase (EC 4.1.2.13)	protein	363	45% helix, 15% strand	P00883

Pockets

15 pockets found on a 1 Å grid, 11 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	1023	0.88	0.90	120	empty
2	772	0.80	0.84	111	empty
3	630	0.78	0.83	80	empty
4	752	0.72	0.78	73	empty
5	191	0.68	0.87	48	empty

Interfaces

6 interfaces between chains.

B–C · 1389 Å² buried · 21 hydrogen bonds · protein-protein
A–D · 1370 Å² buried · 21 hydrogen bonds · protein-protein
C–D · 1197 Å² buried · 15 hydrogen bonds · protein-protein
A–B · 1183 Å² buried · 19 hydrogen bonds · protein-protein
A–C · 112 Å² buried · 1 hydrogen bond · protein-protein

Compared structures

1EWD · Fructose 1,6-bisphosphate aldolase from rabbit muscle · the same entry in another collection · chain D against D, TM-score 1.00
P00883 · AlphaFold monomer V2.0 prediction for fructose-bisphosphate aldolase a (P00883) · a predicted model of the same protein · chain B against A, TM-score 0.97

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P00883
Elsewhere: RCSB PDB 1EWD · PDBe 1EWD · UniProt P00883

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