MolNFT v1 · #70297 · protein
Crystal structure of rabbit muscle aldolase-SNX9 LC4 complex
3LGE · Fructose-bisphosphate aldolase a: “Crystal structure of rabbit muscle aldolase-SNX9 LC4 complex”. X-ray diffraction, 17 pockets (best druggability 0.89). MolNFT v1 #70297 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 3LGE
- Type
- protein
- Length
- 1,454 residues
- Chains
- 8
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Fructose-bisphosphate aldolase a; Sorting nexin-9
- EC
- 4.1.2.13
- UniProt
- P00883, Q9Y5X1
- Pockets
- 17 · best druggability 0.89
Structure
x-ray diffraction · 4 distinct chains · 47% helix, 15% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, D | Fructose-bisphosphate aldolase a (EC 4.1.2.13) | protein | 349 | 46% helix, 15% strand | P00883 |
| B, C | Fructose-bisphosphate aldolase a (EC 4.1.2.13) | protein | 352 | 48% helix, 15% strand | P00883 |
| E, H | Sorting nexin-9 | protein | 7 | 0% helix, 0% strand | Q9Y5X1 |
| F, G | Sorting nexin-9 | protein | 19 | 53% helix, 0% strand | Q9Y5X1 |
Pockets
17 pockets found on a 1 Å grid, 11 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 1081 | 0.89 | 0.90 | 115 | empty |
| 2 | 550 | 0.83 | 0.88 | 79 | empty |
| 3 | 764 | 0.79 | 0.82 | 106 | empty |
| 4 | 60 | 0.70 | 0.97 | 24 | empty |
| 5 | 233 | 0.67 | 0.84 | 46 | empty |
Interfaces
10 interfaces between chains.
- A–B · 1485 Ų buried · 20 hydrogen bonds · protein-protein
- C–D · 1469 Ų buried · 19 hydrogen bonds · protein-protein
- A–D · 1368 Ų buried · 24 hydrogen bonds · protein-protein
- B–C · 1367 Ų buried · 24 hydrogen bonds · protein-protein
- C–G · 986 Ų buried · 10 hydrogen bonds · protein-protein
Compared structures
- 3LGE · Crystal structure of rabbit muscle aldolase-SNX9 LC4 complex · the same entry in another collection · chain H against H, TM-score 1.00
- P00883 · AlphaFold monomer V2.0 prediction for fructose-bisphosphate aldolase a (P00883) · a predicted model of the same protein · chain A against A, TM-score 0.98
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P00883
- Every structure of UniProt Q9Y5X1
- Elsewhere: RCSB PDB 3LGE · PDBe 3LGE · UniProt P00883 · UniProt Q9Y5X1
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