UniProt P00772
Chymotrypsin-like elastase family member 1 (P00772)
Chymotrypsin-like elastase family member 1 (UniProt P00772), EC 3.4.21.36: 238 experimental structures and 1 predicted model on GenesisL1, 15 ligands bound, 6 pockets. Binding sites, druggability and experiment against prediction…
- UniProt
- P00772
- Protein
- Chymotrypsin-like elastase family member 1
- EC
- 3.4.21.36
- Experimental structures
- 238
- Predicted models
- 1
- Ligands
- 15
- Pockets
- 6 · 3 records with a druggable one
Structures
239 records of P00772 in the MolNFT archive: 238 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 1B0E | Crystal structure of porcine pancreatic elastase with mdl 101,146 | x-ray diffraction | A | — | — |
| 1B0E | Crystal structure of porcine pancreatic elastase with mdl 101,146 | x-ray diffraction | A | — | — |
| 1BMA | Benzyl methyl aminimide inhibitor complexed to porcine pancreatic elastase | x-ray diffraction | A | — | — |
| 1BMA | Benzyl methyl aminimide inhibitor complexed to porcine pancreatic elastase | x-ray diffraction | A | — | — |
| 1BTU | Porcine pancreatic elastase complexed with (3S, 4R)-1-toluenesulphonyl-3-ethyl-azetidin-2-one-4-carb… | x-ray diffraction | A | — | — |
| 1BTU | Porcine pancreatic elastase complexed with (3S, 4R)-1… | x-ray diffraction | A | — | — |
| 1C1M | Porcine elastase under xenon pressure (8 bar) | x-ray diffraction | A | — | — |
| 1C1M | Porcine elastase under xenon pressure (8 bar) | x-ray diffraction | A | — | — |
| 1E34 | Porcine pancreatic elastase complexed with (3S, 4S)N-para- toluenesulphonyl-3-ethyl-4-(carboxylic… | x-ray diffraction | B | — | — |
| 1E34 | Porcine pancreatic elastase complexed with (3S, 4S)N-para- toluenesulphonyl-3-ethyl-4-(carboxylic… | x-ray diffraction | B | — | — |
| 1E35 | Porcine pancreatic elastase complexed with (3S, 4S)N-para-toluenesulphonyl -3-ethyl-4-(carboxylic… | x-ray diffraction | B | — | — |
| 1E35 | Porcine pancreatic elastase complexed with (3S, 4S)N-para- toluenesulphonyl -3-ethyl-4-(carboxylic… | x-ray diffraction | B | — | — |
| 1E36 | Porcine pancreatic elastase complexed with (3S, 4S)N-para-nitrobenzenesulphonyl… | x-ray diffraction | B | — | — |
| 1E36 | Porcine pancreatic elastase complexed with (3S, 4S)N-para- nitrobenzenesulphonyl… | x-ray diffraction | B | — | — |
| 1E37 | Porcine pancreatic elastase complexed with (3S, 4S)N-para-nitrobenzenesulphonyl… | x-ray diffraction | B | — | — |
| 1E37 | Porcine pancreatic elastase complexed with (3S, 4S)N-para-nitrobenzenesulphonyl… | x-ray diffraction | B | — | — |
| 1E38 | Porcine pancreatic elastase complexed with (3S, 4S)N-para-nitrobenzenesulphonyl… | x-ray diffraction | B | — | — |
| 1E38 | Porcine pancreatic elastase complexed with (3S, 4S)N-para-nitrobenzenesulphonyl… | x-ray diffraction | B | — | — |
| 1EAI | Complex of ascaris CHYMOTRPSIN/ELASTASE inhibitor with porcine elastase | x-ray diffraction | A, B | — | — |
| 1EAI | Complex of ascaris CHYMOTRPSIN/ELASTASE inhibitor with porcine elastase | x-ray diffraction | A, B | — | — |
| 1EAS | Nonpeptidic inhibitors of human leukocyte elastase. 3. design, synthesis, X-ray crystallographic… | x-ray diffraction | A | — | — |
| 1EAS | Nonpeptidic inhibitors of human leukocyte elastase. 3. design, synthesis, X-ray crystallographic… | x-ray diffraction | A | — | — |
| 1EAT | Nonpeptidic inhibitors of human leukocyte elastase. 5. design, synthesis, and X-ray crystallography… | x-ray diffraction | A | — | — |
| 1EAT | Nonpeptidic inhibitors of human leukocyte elastase. 5. design, synthesis, and X-ray crystallography… | x-ray diffraction | A | — | — |
| 1EAU | Nonpeptidic inhibitors of human leukocyte elastase. 6. design of a potent, intratracheally active… | x-ray diffraction | A | — | — |
| 1EAU | Nonpeptidic inhibitors of human leukocyte elastase. 6. design of a potent, intratracheally active… | x-ray diffraction | A | — | — |
| 1ELA | Analogous inhibitors of elastase do not always bind analogously | x-ray diffraction | A | — | — |
| 1ELA | Analogous inhibitors of elastase do not always bind analogously | x-ray diffraction | A | — | — |
| 1ELB | Analogous inhibitors of elastase do not always bind analogously | x-ray diffraction | A | — | — |
| 1ELB | Analogous inhibitors of elastase do not always bind analogously | x-ray diffraction | A | — | — |
| 1ELC | Analogous inhibitors of elastase do not always bind analogously | x-ray diffraction | A | — | — |
| 1ELC | Analogous inhibitors of elastase do not always bind analogously | x-ray diffraction | A | — | — |
| 1ELD | Structural analysis of the active site of porcine pancreatic elastase based on the x-ray crystal… | x-ray diffraction | E | — | — |
| 1ELD | Structural analysis of the active site of porcine pancreatic elastase based on the X-ray crystal… | x-ray diffraction | E | — | — |
| 1ELE | Structural analysis of the active site of porcine pancreatic elastase based on the X-ray crystal… | x-ray diffraction | E | — | — |
| 1ELE | Structural analysis of the active site of porcine pancreatic elastase based on the X-ray crystal… | x-ray diffraction | E | — | — |
| 1ELF | Nature of the inactivation of elastase by N-peptidyl-O-aroyl hydroxylamine as a function of pH | x-ray diffraction | A | — | — |
| 1ELF | Nature of the inactivation of elastase by N-peptidyl-O- aroyl hydroxylamine as a function of pH | x-ray diffraction | A | — | — |
| 1ELG | Nature of the inactivation of elastase by N-peptidyl-O-aroyl hydroxylamine as a function of pH | x-ray diffraction | A | — | — |
| 1ELG | Nature of the inactivation of elastase by N-peptidyl-O- aroyl hydroxylamine as a function of pH | x-ray diffraction | A | — | — |
| 1ESA | Direct structure observation of an acyl-enzyme intermediate in the hydrolysis of an ester substrate… | x-ray diffraction | A | — | — |
| 1ESA | Direct structure observation of an acyl-enzyme intermediate in the hydrolysis of an ester substrate… | x-ray diffraction | A | — | — |
| 1ESB | Direct structure observation of an acyl-enzyme intermediate in the hydrolysis of an ester substrate… | x-ray diffraction | A | — | — |
| 1ESB | Direct structure observation of an acyl-enzyme intermediate in the hydrolysis of an ester substrate… | x-ray diffraction | A | — | — |
| 1EST | The atomic structure of crystalline porcine pancreatic elastase at 2.5 ångströms resolution.… | x-ray diffraction | A | — | — |
| 1EST | The atomic structure of crystalline porcine pancreatic elastase at 2.5 ångströms resolution.… | x-ray diffraction | A | — | — |
| 1FLE | Crystal structure of elafin complexed with porcine pancreatic elastase | x-ray diffraction | E | — | — |
| 1FLE | Crystal structure of elafin complexed with porcine pancreatic elastase | x-ray diffraction | E | — | — |
| 1FZZ | The crystal structure of the complex of non-peptidic inhibitor ono-6818 and porcine pancreatic… | x-ray diffraction | A | — | — |
| 1FZZ | The crystal structure of the complex of non-peptidic inhibitor ono- 6818 and porcine pancreatic… | x-ray diffraction | A | — | — |
| 1GVK | Porcine pancreatic elastase acyl enzyme at 0.95 A resolution | x-ray diffraction | B | — | — |
| 1GVK | Porcine pancreatic elastase acyl enzyme at 0.95 a resolution | x-ray diffraction | B | — | — |
| 1GWA | Triiodide derivative of porcine pancreas elastase | x-ray diffraction | A | — | — |
| 1GWA | Triiodide derivative of porcine pancreas elastase | x-ray diffraction | A | — | — |
| 1H9L | Porcine pancreatic elastase complexed with acetyl-val-glu-pro-ile-cooh | x-ray diffraction | B | — | — |
| 1H9L | Porcine pancreatic elastase complexed with acetyl-val-glu-pro-ile-cooh | x-ray diffraction | B | — | — |
| 1HAX | Snapshots of serine protease catalysis: (A) acyl-enzyme intermediate between porcine pancreatic… | x-ray diffraction | B | — | — |
| 1HAX | Snapshots of serine protease catalysis: (a) acyl-enzyme intermediate between porcine pancreatic… | x-ray diffraction | B | — | — |
| 1HAY | Snapshots of serine protease catalysis: (B) acyl-enzyme intermediate between porcine pancreatic… | x-ray diffraction | B | — | — |
| 1HAY | Snapshots of serine protease catalysis: (B) acyl-enzyme intermediate between porcine pancreatic… | x-ray diffraction | B | — | — |
179 records more on the page itself.
Ligands
- CA · Calcium ion · in 9 records
- SO4 · Sulfate ion · in 8 records
- NA · Sodium ion · in 4 records
- PO4 · Phosphate ion · in 3 records
- IBR · (2-bromoethyl)(2-'formyl-4'-aminophenyl) acetate · in 2 records
- 0P2 · N~2~-[(benzyloxy)carbonyl]-N-[(1R,2S)-1-(dihydroxyboranyl)-2-methylbutyl]-L-alaninamide · in 1 record
- AR · Argon · in 1 record
- GIS · Ethyl-(2-carboxy-4-guanidinium-phenyl)-chloroacetate · in 1 record
- HVZ · ~{N}-[[1-[(4-chlorophenyl)methyl]-1,2,3-triazol-4-yl]methyl]-2-hydrosulfonyl-2-methyl-propanamide · in 1 record
- J02 · 2-methyl-1-[[1-[(4-nitrophenyl)methyl]-1,2,3-triazol-4-yl]methylamino]-1-oxidanylidene-propane-2-sulfonic acid · in 1 record
- J05 · 1-[[1-[(4-bromophenyl)methyl]-1,2,3-triazol-4-yl]methylamino]-2-methyl-1-oxidanylidene-propane-2-sulfonic acid · in 1 record
- N9K · (2~{S})-3-(4-hydroxyphenyl)-2-(methylamino)propanoic acid · in 1 record
- O4Q · (~{E})-4-chloranyl-3-methyl-but-3-enal · in 1 record
- OU0 · 2-cyclopropylcarbonyl-3-propan-2-yl-1,2-oxazol-5-one · in 1 record
- SO3 · Sulfite ion · in 1 record
Experiment against prediction
- 3E3T chain A against the predicted model P00772: TM-score 1.00, RMSD 0.21 Å
- 3E3T chain A against the predicted model P00772: TM-score 1.00, RMSD 0.21 Å
- 2V35 chain A against the predicted model P00772: TM-score 1.00, RMSD 0.22 Å
- 2V35 chain A against the predicted model P00772: TM-score 1.00, RMSD 0.22 Å
- 2BD4 chain A against the predicted model P00772: TM-score 1.00, RMSD 0.22 Å
- 2BD4 chain A against the predicted model P00772: TM-score 1.00, RMSD 0.22 Å
- 2BD3 chain A against the predicted model P00772: TM-score 1.00, RMSD 0.22 Å
- 2BD2 chain A against the predicted model P00772: TM-score 1.00, RMSD 0.23 Å
- 2BD8 chain A against the predicted model P00772: TM-score 1.00, RMSD 0.23 Å
- 2BD8 chain A against the predicted model P00772: TM-score 1.00, RMSD 0.23 Å
Elsewhere
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.