SEI · 1-{3-methyl-2-[4-(morpholine-4-carbonyl)-benzoylamino]-butyryl}-pyrrolidine-2-carboxylic acid (3,3,4,4,4-pentafluoro-1-isopropyl-2-oxo-butyl)-amide

Binding sites

SEI in 4 structures; the first of them:

• 1B0E · Crystal structure of porcine pancreatic elastase with mdl 101,146 · SEI A260 · binds THR41, CYS42, HIS57, CYS58, VAL99, ALA99A, TRP172, THR175 and 11 more
• 1B0F · Crystal structure of human neutrophil elastase with mdl 101, 146 · SEI A300 · binds PHE41, CYS42, HIS57, CYS58, LEU99B, ARG177, VAL190, CYS191 and 8 more
• 1B0E · Crystal structure of porcine pancreatic elastase with mdl 101,146 · SEI A260 · binds THR41, CYS42, HIS57, CYS58, VAL99, ALA99A, TRP172, THR175 and 11 more
• 1B0F · Crystal structure of human neutrophil elastase with mdl 101, 146 · SEI A300 · binds PHE41, CYS42, HIS57, CYS58, LEU99B, ARG177, VAL190, CYS191 and 8 more

Residues it binds most

CYS 4, SER 4, PHE 4, VAL 4, ARG 4, THR 2, ASP 4, GLY 4, HIS 4, ALA 2 (residue and the binding sites it lines).

Found with

• CA · Calcium ion
• FUC · alpha-L-fucopyranose
• NAG · 2-acetamido-2-deoxy-beta-D-glucopyranose