UniProt P00581
DNA polymerase (P00581)
DNA polymerase (UniProt P00581), EC 2.7.7.7, 3.1.11.-: 48 experimental structures on GenesisL1, 7 ligands bound, 147 pockets. Binding sites, pockets, druggability and 3D structures in GL1X.
- UniProt
- P00581
- Protein
- DNA polymerase
- EC
- 2.7.7.7, 3.1.11.-
- Experimental structures
- 48
- Predicted models
- 0
- Ligands
- 7
- Pockets
- 147 · 17 records with a druggable one
Structures
48 records of P00581 in the MolNFT archive: 48 experimental, 0 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 1SKR | T7 DNA Polymerase Complexed To DNA Primer/Template and ddATP | x-ray diffraction | A | MG, DAD | 6 (best 0.78) |
| 1SKR | T7 DNA polymerase complexed to DNA PRIMER/TEMPLATE and ddatp | x-ray diffraction | A | — | — |
| 1SKS | Binary 3' complex of T7 DNA polymerase with a DNA primer/template containing a cis-syn thymine… | x-ray diffraction | A | MG | 8 (best 0.75) |
| 1SKS | Binary 3' complex of T7 DNA polymerase with a DNA PRIMER/TEMPLATE containing a cis-syn thymine… | x-ray diffraction | A | — | — |
| 1SKW | Binary 3' complex of T7 DNA polymerase with a DNA primer/template containing a disordered cis-syn… | x-ray diffraction | A | MG | 8 (best 0.75) |
| 1SKW | Binary 3' complex of T7 DNA polymerase with a DNA PRIMER/TEMPLATE containing a disordered cis-syn… | x-ray diffraction | A | — | — |
| 1SL0 | Ternary 3' complex of T7 DNA polymerase with a DNA primer/template containing a disordered cis-syn… | x-ray diffraction | A, C | MG, DAD | 17 (best 0.79) |
| 1SL0 | Ternary 3' complex of T7 DNA polymerase with a DNA PRIMER/TEMPLATE containing a disordered cis-syn… | x-ray diffraction | A, C | — | — |
| 1SL1 | Binary 5' complex of T7 DNA polymerase with a DNA primer/template containing a cis-syn thymine… | x-ray diffraction | A | MG | 8 (best 0.76) |
| 1SL1 | Binary 5' complex of T7 DNA polymerase with a DNA PRIMER/TEMPLATE containing a cis-syn thymine… | x-ray diffraction | A | — | — |
| 1SL2 | Ternary 5' complex of T7 DNA polymerase with a DNA primer/template containing a cis-syn thymine… | x-ray diffraction | A | MG, DAD | 6 (best 0.75) |
| 1SL2 | Ternary 5' complex of T7 DNA polymerase with a DNA PRIMER/TEMPLATE containing a cis-syn thymine… | x-ray diffraction | A | — | — |
| 1T7P | T7 DNA polymerase complexed to DNA PRIMER/TEMPLATE,A nucleoside triphosphate, and its processivity… | x-ray diffraction | A | DG3, MG | 6 (best 0.75) |
| 1T7P | T7 DNA polymerase complexed to DNA PRIMER/TEMPLATE,A nucleoside triphosphate, and its processivity… | x-ray diffraction | A | — | — |
| 1T8E | T7 DNA Polymerase Ternary Complex with dCTP at the Insertion Site. | x-ray diffraction | A | MG, SO4, DCT | 10 (best 0.73) |
| 1T8E | T7 DNA polymerase ternary complex with dctp at the insertion site. | x-ray diffraction | A | — | — |
| 1TK0 | T7 DNA polymerase ternary complex with 8 oxo guanosine and ddCTP at the insertion site | x-ray diffraction | A | MG, SO4, DCT | 7 (best 0.74) |
| 1TK0 | T7 DNA polymerase ternary complex with 8 oxo guanosine and ddctp at the insertion site | x-ray diffraction | A | — | — |
| 1TK5 | T7 DNA polymerase binary complex with 8 oxo guanosine in the templating strand | x-ray diffraction | A | MG, SO4 | 6 (best 0.75) |
| 1TK5 | T7 DNA polymerase binary complex with 8 oxo guanosine in the templating strand | x-ray diffraction | A | — | — |
| 1TK8 | T7 DNA polymerase ternary complex with 8 oxo guanosine and dAMP at the elongation site | x-ray diffraction | A | MG, SO4, D3T | 5 (best 0.78) |
| 1TK8 | T7 DNA polymerase ternary complex with 8 oxo guanosine and damp at the elongation site | x-ray diffraction | A | — | — |
| 1TKD | T7 DNA polymerase ternary complex with 8 oxo guanosine and dCMP at the elongation site | x-ray diffraction | A | MG, SO4, D3T | 8 (best 0.75) |
| 1TKD | T7 DNA polymerase ternary complex with 8 oxo guanosine and dcmp at the elongation site | x-ray diffraction | A | — | — |
| 1X9M | T7 DNA polymerase in complex with an N-2-acetylaminofluorene-adducted DNA | x-ray diffraction | A | MG | 7 (best 0.76) |
| 1X9M | T7 DNA polymerase in complex with an N-2- acetylaminofluorene-adducted DNA | x-ray diffraction | A | — | — |
| 1X9S | T7 DNA polymerase in complex with a primer/template DNA containing a disordered N-2 aminofluorene… | x-ray diffraction | A | MG | 7 (best 0.74) |
| 1X9S | T7 DNA polymerase in complex with a PRIMER/TEMPLATE DNA containing a disordered N-2 aminofluorene… | x-ray diffraction | A | — | — |
| 1X9W | T7 DNA polymerase in complex with a primer/template DNA containing a disordered N-2 aminofluorene… | x-ray diffraction | A | MG | 7 (best 0.74) |
| 1X9W | T7 DNA polymerase in complex with a PRIMER/TEMPLATE DNA containing a disordered N-2 aminofluorene… | x-ray diffraction | A | — | — |
| 1ZYQ | T7 DNA polymerase in complex with 8oG and incoming ddATP | x-ray diffraction | A | — | — |
| 1ZYQ | T7 DNA polymerase in complex with 8OG and incoming ddatp | x-ray diffraction | A | — | — |
| 2AJQ | Structure of replicative DNA polymerase provides insigts into the mechanisms for processivity… | x-ray diffraction | A, F | — | — |
| 2AJQ | Structure of replicative DNA polymerase provides insigts into the mechanisms for processivity… | x-ray diffraction | A, F | — | — |
| 5IKN | Crystal Structure of the T7 Replisome in the Absence of DNA | x-ray diffraction | A, B, C | — | — |
| 5IKN | Crystal structure of the T7 replisome in the absence of DNA | x-ray diffraction | A, B, C | — | — |
| 6N7W | Structure of bacteriophage T7 leading-strand DNA polymerase (D5A/E7A)/Trx in complex with a DNA… | electron microscopy | H | MG, TTP | 11 (best 0.77) |
| 6N7W | Structure of bacteriophage T7 leading-strand DNA polymerase (D5A/E7A) /trx in complex with a DNA… | electron microscopy | H | MG, TTP | — |
| 6N9U | Structure of bacteriophage T7 lagging-strand DNA polymerase (D5A/E7A) interacting with primase… | electron microscopy | H | TTP, MG | — |
| 6N9U | Structure of bacteriophage T7 lagging-strand DNA polymerase (D5A/E7A) interacting with primase… | electron microscopy | H | TTP, MG | — |
| 6N9V | Structure of bacteriophage T7 lagging-strand DNA polymerase (D5A/E7A) and gp4 (helicase/primase)… | electron microscopy | H | TTP, MG | — |
| 6N9V | Structure of bacteriophage T7 lagging-strand DNA polymerase (D5A/E7A) and GP4 (HELICASE/PRIMASE)… | electron microscopy | H | TTP, MG | — |
| 6N9W | Structure of bacteriophage T7 lagging-strand DNA polymerase (D5A/E7A) and gp4 (helicase/primase)… | electron microscopy | H | TTP, MG | — |
| 6N9W | Structure of bacteriophage T7 lagging-strand DNA polymerase (D5A/E7A) and GP4 (HELICASE/PRIMASE)… | electron microscopy | H | TTP, MG | — |
| 6N9X | Structure of bacteriophage T7 lagging-strand DNA polymerase (D5A/E7A) and gp4 (helicase/primase)… | electron microscopy | H | TTP, MG | — |
| 6N9X | Structure of bacteriophage T7 lagging-strand DNA polymerase (D5A/E7A) and GP4 (HELICASE/PRIMASE)… | electron microscopy | H | TTP, MG | — |
| 6P7E | Structure of T7 DNA Polymerase Bound to a Primer/Template DNA and a Peptide that Mimics the… | x-ray diffraction | A, B, C, D | TTP, MG | 20 (best 0.81) |
| 6P7E | Structure of T7 DNA polymerase bound to a PRIMER/TEMPLATE DNA and a peptide that mimics the… | x-ray diffraction | A, B, C, D | TTP, MG | — |
Ligands
- MG · Magnesium ion · in 27 records
- TTP · Thymidine-5'-triphosphate · in 12 records
- SO4 · Sulfate ion · in 5 records
- DAD · 2',3'-dideoxyadenosine-5'-triphosphate · in 3 records
- D3T · 2',3'-dideoxy-thymidine-5'-triphosphate · in 2 records
- DCT · 2',3'-dideoxycytidine 5'-triphosphate · in 2 records
- DG3 · 2'-3'-dideoxyguanosine-5'-triphosphate · in 1 record
Elsewhere
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