UniProt P00452
Ribonucleoside-diphosphate reductase 1 subunit alpha (P00452)
Ribonucleoside-diphosphate reductase 1 subunit alpha (UniProt P00452), EC 1.17.4.1: 57 experimental structures and 1 predicted model on GenesisL1, 12 ligands bound, 182 pockets. Binding sites, druggability and experiment against…
- UniProt
- P00452
- Protein
- Ribonucleoside-diphosphate reductase 1 subunit alpha
- EC
- 1.17.4.1
- Experimental structures
- 57
- Predicted models
- 1
- Ligands
- 12
- Pockets
- 182 · 11 records with a druggable one
Structures
58 records of P00452 in the MolNFT archive: 57 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 1QFN | Glutaredoxin-1-ribonucleotide reductase B1 mixed disulfide bond | solution nmr | B | — | — |
| 1QFN | Glutaredoxin-1-ribonucleotide reductase B1 mixed disulfide bond | solution nmr | B | — | — |
| 1R1R | Ribonucleotide reductase R1 protein mutant Y730F with a reduced active site from escherichia COLI | x-ray diffraction | A, B, C | — | — |
| 1R1R | Ribonucleotide reductase R1 protein mutant Y730F with a reduced active site from escherichia COLI | x-ray diffraction | A, B, C | — | — |
| 1RLR | Structure of ribonucleotide reductase protein R1 | x-ray diffraction | A | — | — |
| 1RLR | Structure of ribonucleotide reductase protein R1 | x-ray diffraction | A | — | — |
| 2R1R | Ribonucleotide reductase R1 protein with dttp occupying the specificity site from escherichia COLI | x-ray diffraction | A, B, C | — | — |
| 2R1R | Ribonucleotide reductase R1 protein with dttp occupying the specificity site from escherichia COLI | x-ray diffraction | A, B, C | — | — |
| 2X0X | Ribonucleotide reductase R1 subunit of E. coli to 2.3 A resolution | x-ray diffraction | A, B, C | — | — |
| 2X0X | Ribonucleotide reductase R1 subunit of E. COLI to 2.3 a resolution | x-ray diffraction | A, B, C | — | — |
| 2XAK | Ribonucleotide reductase Y730NO2Y modified R1 subunit of E. coli | x-ray diffraction | A, B, C | — | — |
| 2XAK | Ribonucleotide reductase Y730NO2Y modified R1 subunit of E. COLI | x-ray diffraction | A, B, C | — | — |
| 2XAP | Ribonucleotide reductase Y731NO2Y modified R1 subunit of E. coli to 2. 1 A resolution | x-ray diffraction | A, B, C | — | — |
| 2XAP | Ribonucleotide reductase Y731NO2Y modified R1 subunit of E. COLI to 2. 1 a resolution | x-ray diffraction | A, B, C | — | — |
| 2XAV | Ribonucleotide reductase Y731NO2Y and Y730F modified R1 subunit of E. coli | x-ray diffraction | A, B, C | — | — |
| 2XAV | Ribonucleotide reductase Y731NO2Y and Y730F modified R1 subunit of E. COLI | x-ray diffraction | A, B, C | — | — |
| 2XAW | Ribonucleotide reductase Y730NO2Y and Y731F modified R1 subunit of E. coli | x-ray diffraction | A, B, C | — | — |
| 2XAW | Ribonucleotide reductase Y730NO2Y and Y731F modified R1 subunit of E. COLI | x-ray diffraction | A, B, C | — | — |
| 2XAX | Ribonucleotide reductase Y730NO2Y and Y731A modified R1 subunit of E. coli | x-ray diffraction | A, B, C | — | — |
| 2XAX | Ribonucleotide reductase Y730NO2Y and Y731A modified R1 subunit of E. COLI | x-ray diffraction | A, B, C | — | — |
| 2XAY | Ribonucleotide reductase Y730NO2Y and C439A modified R1 subunit of E. coli | x-ray diffraction | A, B, C | — | — |
| 2XAY | Ribonucleotide reductase Y730NO2Y and C439A modified R1 subunit of E. COLI | x-ray diffraction | A, B, C | — | — |
| 2XAZ | Ribonucleotide reductase Y730NO2Y and C439S modified R1 subunit of E. coli | x-ray diffraction | A, B, C | — | — |
| 2XAZ | Ribonucleotide reductase Y730NO2Y and C439S modified R1 subunit of E. COLI | x-ray diffraction | A, B, C | — | — |
| 2XO4 | Ribonucleotide reductase Y730NH2Y modified R1 subunit of E. COLI | x-ray diffraction | A, B, C | — | — |
| 2XO4 | Ribonucleotide reductase Y730NH2Y modified R1 subunit of E. COLI | x-ray diffraction | A, B, C | — | — |
| 2XO5 | Ribonucleotide reductase Y731NH2Y modified R1 subunit of E. COLI | x-ray diffraction | A, B, C | — | — |
| 2XO5 | Ribonucleotide reductase Y731NH2Y modified R1 subunit of E. COLI | x-ray diffraction | A, B, C | — | — |
| 3R1R | Ribonucleotide reductase R1 protein with amppnp occupying the activity site from escherichia COLI | x-ray diffraction | A, B, C | — | — |
| 3R1R | Ribonucleotide reductase R1 protein with amppnp occupying the activity site from escherichia COLI | x-ray diffraction | A, B, C | — | — |
| 3UUS | Crystal structure of the dATP inhibited E. coli class Ia ribonucleotide reductase complex | x-ray diffraction | A, B, C, D | — | — |
| 3UUS | Crystal structure of the datp inhibited E. COLI class ia ribonucleotide reductase complex | x-ray diffraction | A, B, C, D | — | — |
| 4ERM | Crystal structure of the dATP inhibited E. coli class Ia ribonucleotide reductase complex at 4… | x-ray diffraction | A, B, C, D | — | — |
| 4ERM | Crystal structure of the datp inhibited E. COLI class ia ribonucleotide reductase complex at 4… | x-ray diffraction | A, B, C, D | — | — |
| 4ERP | Crystal structure of a gemcitabine-diphosphate inhibited E. coli class Ia ribonucleotide reductase… | x-ray diffraction | A, B, C, D | — | — |
| 4ERP | Crystal structure of a gemcitabine-diphosphate inhibited E. COLI class ia ribonucleotide reductase… | x-ray diffraction | A, B, C, D | — | — |
| 4R1R | Ribonucleotide reductase R1 protein with substrate, GDP and effector dttp from escherichia COLI | x-ray diffraction | A, B, C | — | — |
| 4R1R | Ribonucleotide reductase R1 protein with substrate, GDP and effector dttp from escherichia COLI | x-ray diffraction | A, B, C | — | — |
| 5CNS | Crystal structure of the datp inhibited E. COLI class ia ribonucleotide reductase complex bound to… | x-ray diffraction | A, B, C, D | — | — |
| 5CNT | Crystal structure of the datp inhibited E. COLI class ia ribonucleotide reductase complex bound to… | x-ray diffraction | A, B, C, D | — | — |
| 5CNU | Crystal structure of the datp inhibited E. COLI class ia ribonucleotide reductase complex bound to… | x-ray diffraction | A, B, C, D | — | — |
| 5CNV | Crystal structure of the datp inhibited E. COLI class ia ribonucleotide reductase complex bound to… | x-ray diffraction | A, B, C, D | — | — |
| 5R1R | Ribonucleotide reductase E441A mutant R1 protein from escherichia COLI | x-ray diffraction | A, B, C | — | 18 (best 0.73) |
| 5R1R | Ribonucleotide reductase E441A mutant R1 protein from escherichia COLI | x-ray diffraction | A, B, C | — | — |
| 6R1R | Ribonucleotide reductase E441D mutant R1 protein from escherichia COLI | x-ray diffraction | A, B, C | — | 19 (best 0.73) |
| 6R1R | Ribonucleotide reductase E441D mutant R1 protein from escherichia COLI | x-ray diffraction | A, B, C | — | — |
| 6W4X | Holocomplex of E. coli class Ia ribonucleotide reductase with GDP and TTP | electron microscopy | A, B | TTP, GDP, MG | 19 (best 0.86) |
| 6W4X | Holocomplex of E. COLI class ia ribonucleotide reductase with GDP and ttp | electron microscopy | A, B | TTP, GDP, MG | — |
| 7R1R | Ribonucleotide reductase E441Q mutant R1 protein from escherichia COLI | x-ray diffraction | A, B, C | — | — |
| 7R1R | Ribonucleotide reductase E441Q mutant R1 protein from escherichia COLI | x-ray diffraction | A, B, C | — | — |
| 8VHN | Crystal Structure of E. coli class Ia ribonucleotide reductase alpha subunit bound to two ATP… | x-ray diffraction | A, B | ATP, MG | 16 (best 0.74) |
| 8VHO | Crystal Structure of E. coli class Ia ribonucleotide reductase alpha subunit bound to dATP | x-ray diffraction | A, B | DTP, MG | 14 (best 0.77) |
| 8VHP | Crystal structure of E. coli class Ia ribonucleotide reductase alpha subunit W28A variant bound to… | x-ray diffraction | A, B, C, D, E, F, G, H | SO4, ATP, MG, CDP | 20 (best 0.77) |
| 8VHQ | Crystal structure of E. coli class Ia ribonucleotide reductase alpha subunit W28A variant bound to… | x-ray diffraction | A, B, C, D | DTP, ATP, MG | 20 (best 0.77) |
| 8VHR | Crystal structure of E. coli class Ia ribonucleotide reductase alpha subunit W28A variant bound to… | x-ray diffraction | A, B, C, D | DTP, MG, GTP | 20 (best 0.79) |
| 8VHU | Crystal structure of dATP bound E. coli class Ia ribonucleotide reductase alpha construct fused… | x-ray diffraction | A, B | DTP, MG, NA, CL | 13 (best 0.75) |
| 9DB2 | Class Ia ribonucleotide reductase with mechanism-based inhibitor N3CDP | electron microscopy | A, B | DTP, MG, ATP, UNL, A1A3L | 18 (best 0.87) |
| P00452 | AlphaFold monomer V2.0 prediction for ribonucleoside-diphosphate reductase 1 subunit alpha (P00452) | predicted | A | — | 5 (best 0.79) |
Ligands
- MG · Magnesium ion · in 9 records
- DTP · 2'-deoxyadenosine 5'-triphosphate · in 5 records
- ATP · Adenosine-5'-triphosphate · in 4 records
- GDP · Guanosine-5'-diphosphate · in 2 records
- TTP · Thymidine-5'-triphosphate · in 2 records
- A1A3L · 4-amino-1-{(3xi)-3-C-amino-2-deoxy-5-O-[(S)-hydroxy(phosphonooxy)phosphoryl]-beta-D-threo-pentofuranosyl}pyrimidin-2(1H)-one · in 1 record
- CDP · Cytidine-5'-diphosphate · in 1 record
- CL · Chloride ion · in 1 record
- GTP · Guanosine-5'-triphosphate · in 1 record
- NA · Sodium ion · in 1 record
- SO4 · Sulfate ion · in 1 record
- UNL · Unknown ligand · in 1 record
Experiment against prediction
- 3R1R chain A against the predicted model P00452: TM-score 0.99, RMSD 1.03 Å
- 3R1R chain A against the predicted model P00452: TM-score 0.99, RMSD 1.03 Å
- 2XAW chain A against the predicted model P00452: TM-score 0.99, RMSD 1.05 Å
- 2XAW chain A against the predicted model P00452: TM-score 0.99, RMSD 1.05 Å
- 4R1R chain A against the predicted model P00452: TM-score 0.99, RMSD 1.02 Å
- 4R1R chain A against the predicted model P00452: TM-score 0.99, RMSD 1.02 Å
- 2XAK chain A against the predicted model P00452: TM-score 0.99, RMSD 1.09 Å
- 2XAK chain A against the predicted model P00452: TM-score 0.99, RMSD 1.09 Å
- 2XAP chain A against the predicted model P00452: TM-score 0.99, RMSD 1.08 Å
- 2XAP chain A against the predicted model P00452: TM-score 0.99, RMSD 1.08 Å
Elsewhere
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