UniProt P00401
Cytochrome c oxidase subunit 1 (P00401)
Cytochrome c oxidase subunit 1 (UniProt P00401), EC 1.9.3.1, 7.1.1.9: 18 experimental structures and 1 predicted model on GenesisL1, 10 ligands bound, 117 pockets. Binding sites, druggability and experiment against prediction…
- UniProt
- P00401
- Protein
- Cytochrome c oxidase subunit 1
- EC
- 1.9.3.1, 7.1.1.9
- Experimental structures
- 18
- Predicted models
- 1
- Ligands
- 10
- Pockets
- 117 · 10 records with a druggable one
Structures
19 records of P00401 in the MolNFT archive: 18 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 6GIQ | Saccharomyces cerevisiae respiratory supercomplex III2IV | electron microscopy | a | CU, HEA | 7 (best 0.91) |
| 6GIQ | Saccharomyces cerevisiae respiratory supercomplex III2IV | electron microscopy | a | CU, HEA | — |
| 6HU9 | III2-IV2 mitochondrial respiratory supercomplex from S. cerevisiae | electron microscopy | a, m | CU, HEA, CA, MG, PEF, PCF | — |
| 6HU9 | III2-IV2 mitochondrial respiratory supercomplex from S. cerevisiae | electron microscopy | a, m | CU, HEA, CA, MG, PEF, PCF | — |
| 6T0B | The III2-IV(5B)2 respiratory supercomplex from S. cerevisiae | electron microscopy | a, n | PEF, CU, HEA, CA, MG, PCF | 7 (best 0.91) |
| 6T0B | The III2-IV(5B)2 respiratory supercomplex from S. cerevisiae | electron microscopy | a, n | PEF, CU, HEA, CA, MG, PCF | — |
| 6T15 | The III2-IV(5B)1 respiratory supercomplex from S. cerevisiae | electron microscopy | a | CU, HEA, MG, PEF, PCF | — |
| 6YMX | CIII2/CIV respiratory supercomplex from Saccharomyces cerevisiae | electron microscopy | a | CU, HEA, PTY, CN3, PCF | 5 (best 0.91) |
| 6YMX | CIII2/CIV respiratory supercomplex from saccharomyces cerevisiae | electron microscopy | a | CU, HEA, PTY, CN3, PCF | — |
| 6YMY | Cytochrome c oxidase from Saccharomyces cerevisiae | electron microscopy | a | CU, HEA, PTY, CN3, PCF | 16 (best 0.91) |
| 6YMY | Cytochrome C oxidase from saccharomyces cerevisiae | electron microscopy | a | CU, HEA, PTY, CN3, PCF | — |
| 7Z10 | Monomeric respiratory complex IV isolated from S. cerevisiae | electron microscopy | a | CU, HEA, MG, PEF | 17 (best 0.91) |
| 7Z10 | Monomeric respiratory complex IV isolated from S. cerevisiae | electron microscopy | a | CU, HEA, MG, PEF | 17 (best 0.91) |
| 8DH6 | Cryo-EM structure of Saccharomyces cerevisiae cytochrome c oxidase (Complex IV) extracted in lipid… | electron microscopy | a | CA, MG, CU, HEA, PEF | 18 (best 0.91) |
| 8DH6 | Cryo-EM structure of saccharomyces cerevisiae cytochrome C oxidase (complex IV) extracted in lipid… | electron microscopy | a | CA, MG, CU, HEA, PEF | — |
| 8E7S | III2IV2 respiratory supercomplex from Saccharomyces cerevisiae with 4 bound UQ6 | electron microscopy | K, k | HEA, CU, CDL, PEF, PCF | 14 (best 0.90) |
| 8EC0 | III2IV respiratory supercomplex from Saccharomyces cerevisiae cardiolipin-lacking mutant | electron microscopy | K | PGT, CU, HEA, PEF | 8 (best 0.89) |
| 9ETZ | III2IV respiratory supercomplex from Saccharomyces cerevisiae | electron microscopy | a | PEF, CU, HEA, CA, MG, PCF | 8 (best 0.88) |
| P00401 | AlphaFold monomer V2.0 prediction for cytochrome C oxidase subunit 1 (P00401) | predicted | A | — | — |
Ligands
- CU · Copper (II) ion · in 18 records
- HEA · Heme-A · in 18 records
- PEF · Di-palmitoyl-3-sn-phosphatidylethanolamine · in 12 records
- PCF · 1,2-diacyl-sn-glycero-3-phoshocholine · in 11 records
- MG · Magnesium ion · in 10 records
- CA · Calcium ion · in 7 records
- CN3 · (2R,5S,11R,14R)-5,8,11-trihydroxy-2-(nonanoyloxy)-5,11-dioxido-16-oxo-14-[(propanoyloxy)methyl]-4,6,10,12,15-pentaoxa-5,11-diphosphanonadec-1-yl undecanoate · in 4 records
- PTY · Phosphatidylethanolamine · in 4 records
- CDL · Cardiolipin · in 1 record
- PGT · (1S)-2-{[{[(2R)-2,3-dihydroxypropyl]oxy}(hydroxy) phosphoryl]oxy}-1-[(palmitoyloxy)methyl]ethyl stearate · in 1 record
Experiment against prediction
- 6HU9 chain a against the predicted model P00401: TM-score 0.96, RMSD 1.85 Å
- 6HU9 chain a against the predicted model P00401: TM-score 0.96, RMSD 1.85 Å
- 6T0B chain a against the predicted model P00401: TM-score 0.96, RMSD 1.83 Å
- 6T0B chain a against the predicted model P00401: TM-score 0.96, RMSD 1.83 Å
- 6HU9 chain m against the predicted model P00401: TM-score 0.96, RMSD 1.85 Å
- 6HU9 chain m against the predicted model P00401: TM-score 0.96, RMSD 1.85 Å
- 8DH6 chain a against the predicted model P00401: TM-score 0.96, RMSD 1.84 Å
- 8DH6 chain a against the predicted model P00401: TM-score 0.96, RMSD 1.84 Å
- 6T0B chain n against the predicted model P00401: TM-score 0.96, RMSD 1.86 Å
- 6T0B chain n against the predicted model P00401: TM-score 0.96, RMSD 1.86 Å
Elsewhere
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