UniProt P00397
Cytochrome c oxidase subunit 1 (P00397)
Cytochrome c oxidase subunit 1 (UniProt P00397), EC 7.1.1.9: 5 experimental structures and 1 predicted model on GenesisL1, 7 ligands bound, 3 pockets. Binding sites, druggability and experiment against prediction (TM-score) in…
- UniProt
- P00397
- Protein
- Cytochrome c oxidase subunit 1
- EC
- 7.1.1.9
- Experimental structures
- 5
- Predicted models
- 1
- Ligands
- 7
- Pockets
- 3 · 1 record with a druggable one
Structures
6 records of P00397 in the MolNFT archive: 5 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 7O37 | Murine supercomplex CIII2CIV in the assembled locked conformation | electron microscopy | a | PC1, TGL, CU, NA, HEA, 3PE | — |
| 7O3C | Murine supercomplex CIII2CIV in the mature unlocked conformation | electron microscopy | a | CU, NA, HEA, 3PE, MG, TGL | — |
| 7O3C | Murine supercomplex CIII2CIV in the mature unlocked conformation | electron microscopy | a | CU, NA, HEA, 3PE, MG, TGL | — |
| 7O3E | Murine supercomplex CIII2CIV in the intermediate locked conformation | electron microscopy | a | CU, NA, HEA, PC1, 3PE, MG | — |
| 8PW6 | C respirasome from murine liver | electron microscopy | n | CU, NA, HEA, 3PE, MG, TGL | 3 (best 0.92) |
| P00397 | AlphaFold monomer V2.0 prediction for cytochrome C oxidase subunit 1 (P00397) | predicted | A | — | — |
Ligands
Experiment against prediction
- 7O37 chain a against the predicted model P00397: TM-score 0.99, RMSD 0.79 Å
- 7O3E chain a against the predicted model P00397: TM-score 0.99, RMSD 0.80 Å
- 8PW6 chain n against the predicted model P00397: TM-score 0.99, RMSD 0.79 Å
- 7O3C chain a against the predicted model P00397: TM-score 0.99, RMSD 0.83 Å
- 7O3C chain a against the predicted model P00397: TM-score 0.99, RMSD 0.83 Å
Elsewhere
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