UniProt O79880
NADH-ubiquinone oxidoreductase chain 3 (O79880)
NADH-ubiquinone oxidoreductase chain 3 (UniProt O79880), EC 1.6.5.3, 7.1.1.2: 84 experimental structures and 1 predicted model on GenesisL1, 6 ligands bound, 192 pockets. Binding sites, druggability and experiment against…
- UniProt
- O79880
- Protein
- NADH-ubiquinone oxidoreductase chain 3
- EC
- 1.6.5.3, 7.1.1.2
- Experimental structures
- 84
- Predicted models
- 1
- Ligands
- 6
- Pockets
- 192 · 65 records with a druggable one
Structures
85 records of O79880 in the MolNFT archive: 84 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 5GPN | Architecture of mammalian respirasome | electron microscopy | g | — | 2 (best 0.89) |
| 5GUP | Cryo-EM structure of mammalian respiratory supercomplex I1III2IV1 | electron microscopy | j | PEE | 3 (best 0.90) |
| 7V2C | Active state complex I from Q10 dataset | electron microscopy | j | PEE, UQ, PLX | 4 (best 0.88) |
| 7V2C | Active state complex I from Q10 dataset | electron microscopy | j | PEE, PLX | — |
| 7V2D | Deactive state complex I from Q10 dataset | electron microscopy | j | PEE, PLX, UQ | 4 (best 0.91) |
| 7V2D | Deactive state complex I from Q10 dataset | electron microscopy | j | PEE, PLX | — |
| 7V2E | Active state complex I from Q10-NADH dataset | electron microscopy | j | PEE, UQ, PLX | 2 (best 0.91) |
| 7V2E | Active state complex I from Q10-NADH dataset | electron microscopy | j | PEE, PLX | — |
| 7V2F | Deactive state complex I from Q10-NADH dataset | electron microscopy | j | PEE, PLX | 4 (best 0.90) |
| 7V2F | Deactive state complex I from Q10-NADH dataset | electron microscopy | j | PEE, PLX | — |
| 7V2H | Active state complex I from DQ-NADH dataset | electron microscopy | j | PEE, UQ, PLX | 2 (best 0.88) |
| 7V2H | Active state complex I from dq-NADH dataset | electron microscopy | j | PEE, PLX | — |
| 7V2K | Deactive state complex I from DQ-NADH dataset | electron microscopy | j | PEE, PLX | 4 (best 0.88) |
| 7V2K | Deactive state complex I from dq-NADH dataset | electron microscopy | j | PEE, PLX | — |
| 7V2R | Active state complex I from Q1-NADH dataset | electron microscopy | j | PEE, UQ, PLX | 2 (best 0.89) |
| 7V2R | Active state complex I from Q1-NADH dataset | electron microscopy | j | PEE, PLX | — |
| 7V30 | Deactive state complex I from Q1-NADH dataset | electron microscopy | j | PEE, PLX | 3 (best 0.91) |
| 7V30 | Deactive state complex I from Q1-NADH dataset | electron microscopy | j | PEE, PLX | — |
| 7V31 | Active state complex I from rote dataset | electron microscopy | j | UQ, PLX, PEE | 4 (best 0.90) |
| 7V31 | Active state complex I from rotenone dataset | electron microscopy | j | PLX, PEE | — |
| 7V32 | Deactive state complex I from rotenone dataset | electron microscopy | j | PEE, PLX | — |
| 7V33 | Active state complex I from rote -NADH dataset | electron microscopy | j | PEE, UQ, PLX | 2 (best 0.88) |
| 7V33 | Active state complex I from rotenone-NADH dataset | electron microscopy | j | PEE, PLX | — |
| 7V3M | Deactive state complex I from rote -NADH dataset | electron microscopy | j | PEE, PLX | — |
| 7V3M | Deactive state complex I from rotenone-NADH dataset | electron microscopy | j | PEE, PLX | — |
| 7VBL | Membrane arm of active state ci from dq-NADH dataset | electron microscopy | j | PEE, PLX | — |
| 7VBP | Membrane arm of deactive state CI from DQ-NADH dataset | electron microscopy | j | PEE, PLX | — |
| 7VBP | Membrane arm of deactive state ci from dq-NADH dataset | electron microscopy | j | PEE, PLX | — |
| 7VC0 | Membrane arm of active state CI from Rote -NADH dataset | electron microscopy | j | PEE, PLX | 2 (best 0.91) |
| 7VC0 | Membrane arm of active state ci from rotenone-NADH dataset | electron microscopy | j | PEE, PLX | — |
| 7VWL | Membrane arm of deactive state CI from rote -NADH dataset | electron microscopy | j | PEE, PLX | 2 (best 0.90) |
| 7VWL | Membrane arm of deactive state ci from rotenone-NADH dataset | electron microscopy | j | PEE, PLX | — |
| 7VXS | Membrane arm of active state CI from Q10 dataset | electron microscopy | j | PEE, PLX | 2 (best 0.79) |
| 7VY1 | Membrane arm of deactive state CI from Q10 dataset | electron microscopy | j | PEE, PLX, UQ | 1 (best 0.89) |
| 7VY9 | Membrane arm of active state CI from Q10-NADH dataset | electron microscopy | j | PEE, PLX | 2 (best 0.91) |
| 7VYE | Membrane arm of deactive state CI from Q10-NADH dataset | electron microscopy | j | PEE, PLX | 2 (best 0.89) |
| 7VYS | Membrane arm of active state CI from Q1-NADH dataset | electron microscopy | j | PEE, PLX | 2 (best 0.90) |
| 7VZV | Active state CI from Q10 dataset, Subclass 1 | electron microscopy | j | PEE, UQ, PLX | 2 (best 0.91) |
| 7VZW | Active state CI from Q10 dataset, Subclass 2 | electron microscopy | j | PEE, UQ, PLX | 3 (best 0.91) |
| 7W00 | Deactive state CI from Q10 dataset, Subclass 1 | electron microscopy | j | PEE, PLX, UQ | 3 (best 0.91) |
| 7W0H | Deactive state CI from Q10 dataset, Subclass 2 | electron microscopy | j | PEE, PLX, UQ | 4 (best 0.89) |
| 7W0R | Active state CI from Q10-NADH dataset, Subclass 1 | electron microscopy | j | PEE, UQ, PLX | 2 (best 0.89) |
| 7W0Y | Active state CI from Q10-NADH dataset, Subclass 2 | electron microscopy | j | PEE, UQ, PLX | 4 (best 0.90) |
| 7W1O | Deactive state CI from Q10-NADH dataset, Subclass 1 | electron microscopy | j | PEE, PLX | 3 (best 0.89) |
| 7W1P | Deactive state CI from Q10-NADH dataset, Subclass 2 | electron microscopy | j | PEE, PLX | 3 (best 0.90) |
| 7W1T | Active state CI from Rote dataset, Subclass 1 | electron microscopy | j | PEE, PLX | 4 (best 0.90) |
| 7W1U | Active state CI from Rote dataset, Subclass 2 | electron microscopy | j | PEE, PLX | 2 (best 0.85) |
| 7W1V | Active state CI from Rote -NADH dataset, Subclass 1 | electron microscopy | j | PEE, PLX | 2 (best 0.89) |
| 7W1Z | Active state CI from Rote -NADH dataset, Subclass 2 | electron microscopy | j | PEE, UQ, PLX | 2 (best 0.89) |
| 7W20 | Active state CI from Rote -NADH dataset, Subclass 3 | electron microscopy | j | PEE, UQ, PLX | 2 (best 0.87) |
| 7W2K | Deactive state CI from Rote -NADH dataset, Subclass 1 | electron microscopy | j | PEE, PLX | 3 (best 0.90) |
| 7W2L | Deactive state CI from Rote -NADH dataset, Subclass 2 | electron microscopy | j | PEE, PLX, UQ | 3 (best 0.91) |
| 7W2R | Active state CI from DQ-NADH dataset, Subclass 1 | electron microscopy | j | PEE, PLX | 2 (best 0.87) |
| 7W2U | Active state CI from DQ-NADH dataset, Subclass 2 | electron microscopy | j | PEE, UQ, PLX | 2 (best 0.84) |
| 7W2Y | Active state CI from DQ-NADH dataset, Subclass 3 | electron microscopy | j | PEE, PLX | 3 (best 0.87) |
| 7W31 | Deactive state CI from DQ-NADH dataset, Subclass 1 | electron microscopy | j | PEE, PLX | 4 (best 0.90) |
| 7W32 | Deactive state CI from DQ-NADH dataset, Subclass 2 | electron microscopy | j | PLX, PEE | 4 (best 0.90) |
| 7W35 | Deactive state CI from DQ-NADH dataset, Subclass 3 | electron microscopy | j | PEE, PLX | 4 (best 0.89) |
| 7W4C | Active state CI from Q1-NADH dataset, Subclass 1 | electron microscopy | j | PEE, PLX | 2 (best 0.87) |
| 7W4E | Active state CI from Q1-NADH dataset, Subclass 3 | electron microscopy | j | PEE, PLX | 1 (best 0.86) |
25 records more on the page itself.
Ligands
- PEE · 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine · in 65 records
- PLX · (9R,11S)-9-({[(1S)-1-hydroxyhexadecyl]oxy}methyl)-2,2-dimethyl-5,7,10-trioxa-2lambda~5~-aza-6lambda~5~-phosphaoctacosane-6,6,11-triol · in 64 records
- UQ · Coenzyme Q10, (2Z,6E,10Z,14E,18E,22E,26Z)-isomer · in 20 records
- PC1 · 1,2-diacyl-sn-glycero-3-phosphocholine · in 17 records
- 3PE · 1,2-diacyl-sn-glycero-3-phosphoethanolamine · in 13 records
- U10 · Ubiquinone-10 · in 3 records
Experiment against prediction
- 8UEV chain 1A against the predicted model O79880: TM-score 0.92, RMSD 1.20 Å
- 8UET chain 1A against the predicted model O79880: TM-score 0.91, RMSD 1.30 Å
- 8UEY chain 1A against the predicted model O79880: TM-score 0.91, RMSD 1.38 Å
- 8UEX chain 1A against the predicted model O79880: TM-score 0.91, RMSD 1.39 Å
- 5GPN chain g against the predicted model O79880: TM-score 0.90, RMSD 1.40 Å
- 8UES chain 1A against the predicted model O79880: TM-score 0.89, RMSD 1.66 Å
- 8UGI chain 1A against the predicted model O79880: TM-score 0.89, RMSD 1.70 Å
- 8UGJ chain 1A against the predicted model O79880: TM-score 0.89, RMSD 1.72 Å
- 8UEW chain 1A against the predicted model O79880: TM-score 0.89, RMSD 1.72 Å
- 8UGH chain 1A against the predicted model O79880: TM-score 0.89, RMSD 1.71 Å
Elsewhere
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