UniProt O79875
NADH-ubiquinone oxidoreductase chain 2 (O79875)
NADH-ubiquinone oxidoreductase chain 2 (UniProt O79875), EC 1.6.5.3, 7.1.1.2: 59 experimental structures and 1 predicted model on GenesisL1, 7 ligands bound, 171 pockets. Binding sites, druggability and experiment against…
- UniProt
- O79875
- Protein
- NADH-ubiquinone oxidoreductase chain 2
- EC
- 1.6.5.3, 7.1.1.2
- Experimental structures
- 59
- Predicted models
- 1
- Ligands
- 7
- Pockets
- 171 · 40 records with a druggable one
Structures
60 records of O79875 in the MolNFT archive: 59 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 5GPN | Architecture of mammalian respirasome | electron microscopy | f | — | 1 (best 0.81) |
| 5GUP | Cryo-EM structure of mammalian respiratory supercomplex I1III2IV1 | electron microscopy | i | CDL, PEE, PLX | 2 (best 0.82) |
| 7V2C | Active state complex I from Q10 dataset | electron microscopy | i | PEE, CDL, PLX | — |
| 7V2D | Deactive state complex I from Q10 dataset | electron microscopy | i | CDL, PEE, PLX | 4 (best 0.82) |
| 7V2D | Deactive state complex I from Q10 dataset | electron microscopy | i | CDL, PEE, PLX | — |
| 7V2E | Active state complex I from Q10-NADH dataset | electron microscopy | i | PEE, CDL, PLX | 5 (best 0.83) |
| 7V2E | Active state complex I from Q10-NADH dataset | electron microscopy | i | PEE, CDL, PLX | — |
| 7V2F | Deactive state complex I from Q10-NADH dataset | electron microscopy | i | CDL, PEE, PLX | 5 (best 0.90) |
| 7V2F | Deactive state complex I from Q10-NADH dataset | electron microscopy | i | CDL, PEE, PLX | — |
| 7V2H | Active state complex I from dq-NADH dataset | electron microscopy | i | CDL, PEE, PLX | — |
| 7V2K | Deactive state complex I from DQ-NADH dataset | electron microscopy | i | PEE, CDL, PLX | 4 (best 0.86) |
| 7V2K | Deactive state complex I from dq-NADH dataset | electron microscopy | i | PEE, CDL, PLX | — |
| 7V2R | Active state complex I from Q1-NADH dataset | electron microscopy | i | PEE, CDL, PLX | 4 (best 0.83) |
| 7V2R | Active state complex I from Q1-NADH dataset | electron microscopy | i | PEE, CDL, PLX | — |
| 7V30 | Deactive state complex I from Q1-NADH dataset | electron microscopy | i | PEE, CDL, PLX | 4 (best 0.86) |
| 7V30 | Deactive state complex I from Q1-NADH dataset | electron microscopy | i | PEE, CDL, PLX | — |
| 7V31 | Active state complex I from rote dataset | electron microscopy | i | PEE, CDL, PLX | 4 (best 0.83) |
| 7V31 | Active state complex I from rotenone dataset | electron microscopy | i | PEE, CDL, PLX | — |
| 7V32 | Deactive state complex I from rotenone dataset | electron microscopy | i | PLX, CDL, PEE | — |
| 7V33 | Active state complex I from rote -NADH dataset | electron microscopy | i | CDL, PLX, PEE | 5 (best 0.84) |
| 7V33 | Active state complex I from rotenone-NADH dataset | electron microscopy | i | CDL, PLX, PEE | — |
| 7V3M | Deactive state complex I from rote -NADH dataset | electron microscopy | i | PEE, PLX, CDL | — |
| 7V3M | Deactive state complex I from rotenone-NADH dataset | electron microscopy | i | PEE, PLX, CDL | — |
| 7VBL | Membrane arm of active state ci from dq-NADH dataset | electron microscopy | i | CDL, PLX, PEE | — |
| 7VBP | Membrane arm of deactive state CI from DQ-NADH dataset | electron microscopy | i | PEE, PLX, CDL | — |
| 7VBP | Membrane arm of deactive state ci from dq-NADH dataset | electron microscopy | i | PEE, PLX, CDL | — |
| 7VC0 | Membrane arm of active state ci from rotenone-NADH dataset | electron microscopy | i | PEE, CDL, PLX | — |
| 7VWL | Membrane arm of deactive state ci from rotenone-NADH dataset | electron microscopy | i | CDL, PLX, PEE | — |
| 7VXS | Membrane arm of active state CI from Q10 dataset | electron microscopy | i | CDL, PLX, PEE | 6 (best 0.83) |
| 7VY1 | Membrane arm of deactive state CI from Q10 dataset | electron microscopy | i | CDL, PLX, PEE | 6 (best 0.86) |
| 7VYE | Membrane arm of deactive state CI from Q10-NADH dataset | electron microscopy | i | CDL, PLX, PEE | 7 (best 0.83) |
| 7VYS | Membrane arm of active state CI from Q1-NADH dataset | electron microscopy | i | CDL, PLX, PEE | 8 (best 0.84) |
| 7VZW | Active state CI from Q10 dataset, Subclass 2 | electron microscopy | i | PEE, CDL, PLX | 5 (best 0.83) |
| 7W0H | Deactive state CI from Q10 dataset, Subclass 2 | electron microscopy | i | CDL, PLX, PEE | 4 (best 0.85) |
| 7W1O | Deactive state CI from Q10-NADH dataset, Subclass 1 | electron microscopy | i | CDL, PEE, PLX | 5 (best 0.82) |
| 7W1U | Active state CI from Rote dataset, Subclass 2 | electron microscopy | i | CDL, PLX, PEE | 3 (best 0.83) |
| 7W1V | Active state CI from Rote -NADH dataset, Subclass 1 | electron microscopy | i | CDL, PLX, PEE | 4 (best 0.83) |
| 7W20 | Active state CI from Rote -NADH dataset, Subclass 3 | electron microscopy | i | CDL, PLX, PEE | 5 (best 0.83) |
| 7W2K | Deactive state CI from Rote -NADH dataset, Subclass 1 | electron microscopy | i | PEE, PLX, CDL | 5 (best 0.90) |
| 7W2L | Deactive state CI from Rote -NADH dataset, Subclass 2 | electron microscopy | i | PEE, PLX, CDL | 4 (best 0.85) |
| 7W2R | Active state CI from DQ-NADH dataset, Subclass 1 | electron microscopy | i | CDL, PEE, PLX | 5 (best 0.83) |
| 7W2U | Active state CI from DQ-NADH dataset, Subclass 2 | electron microscopy | i | CDL, PEE, PLX | 5 (best 0.83) |
| 7W35 | Deactive state CI from DQ-NADH dataset, Subclass 3 | electron microscopy | i | PLX, CDL, PEE | 4 (best 0.83) |
| 7W4E | Active state CI from Q1-NADH dataset, Subclass 3 | electron microscopy | i | PEE, CDL, PLX | 3 (best 0.86) |
| 7W4G | Active state CI from Q1-NADH dataset, Subclass 5 | electron microscopy | i | PEE, CDL, PLX | 4 (best 0.83) |
| 7W4J | Deactive state CI from Q1-NADH dataset, Subclass 1 | electron microscopy | i | CDL, PLX, PEE | — |
| 7W4N | Deactive state CI from Q1-NADH dataset, Subclass 5 | electron microscopy | i | PLX, CDL, PEE | 4 (best 0.84) |
| 7W4Q | Deactive state CI from Q1-NADH dataset, Subclass 6 | electron microscopy | i | PEE, PLX, CDL | 3 (best 0.86) |
| 8UD1 | High resolution in-situ structure of complex I in respiratory supercomplex (composite) | electron microscopy | 1N | 3PE, CDL, PC1 | 3 (best 0.86) |
| 8UEO | In-situ complex I (Active-Apo) | electron microscopy | 1N | 3PE, CDL, PC1 | 3 (best 0.86) |
| 8UES | In-situ complex I, Deactive class01 | electron microscopy | 1N | 3PE, CDL, PGT | 3 (best 0.84) |
| 8UET | In-situ complex I, Deactive class02 | electron microscopy | 1N | 3PE, PGT, CDL | 3 (best 0.85) |
| 8UEV | In-situ complex I, Deactive class04 | electron microscopy | 1N | PGT, 3PE, CDL | 5 (best 0.85) |
| 8UEW | In-situ complex I, Deactive class05 | electron microscopy | 1N | PGT, 3PE, CDL | 3 (best 0.86) |
| 8UEX | In-situ complex I, Deactive class06 | electron microscopy | 1N | 3PE, CDL, PGT | 5 (best 0.85) |
| 8UEY | In-situ complex I, Deactive class07 | electron microscopy | 1N | PGT, 3PE, CDL | 4 (best 0.83) |
| 8UGJ | In-situ structure of typeB supercomplex in respiratory chain (composite) | electron microscopy | 1N | 3PE, CDL, PC1, AME | 3 (best 0.86) |
| 8UGN | In-situ structure of typeO supercomplex in respiratory chain (composite) | electron microscopy | 1N, 5N | 3PE, CDL, PC1, AME | 5 (best 0.86) |
| 8UGR | In-situ structure of typeX supercomplex in respiratory chain (composite) | electron microscopy | 1N, 5N | 3PE, CDL, PC1, AME | 3 (best 0.87) |
| O79875 | AlphaFold monomer V2.0 prediction for NADH-ubiquinone oxidoreductase chain 2 (O79875) | predicted | A | — | 3 (best 0.32) |
Ligands
- CDL · Cardiolipin · in 58 records
- PEE · 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine · in 47 records
- PLX · (9R,11S)-9-({[(1S)-1-hydroxyhexadecyl]oxy}methyl)-2,2-dimethyl-5,7,10-trioxa-2lambda~5~-aza-6lambda~5~-phosphaoctacosane-6,6,11-triol · in 47 records
- 3PE · 1,2-diacyl-sn-glycero-3-phosphoethanolamine · in 11 records
- PGT · (1S)-2-{[{[(2R)-2,3-dihydroxypropyl]oxy}(hydroxy) phosphoryl]oxy}-1-[(palmitoyloxy)methyl]ethyl stearate · in 6 records
- PC1 · 1,2-diacyl-sn-glycero-3-phosphocholine · in 5 records
- AME · N-acetylmethionine · in 3 records
Experiment against prediction
- 7VC0 chain i against the predicted model O79875: TM-score 0.99, RMSD 0.50 Å
- 7VYS chain i against the predicted model O79875: TM-score 0.99, RMSD 0.50 Å
- 7V33 chain i against the predicted model O79875: TM-score 0.99, RMSD 0.50 Å
- 7V33 chain i against the predicted model O79875: TM-score 0.99, RMSD 0.50 Å
- 7W1U chain i against the predicted model O79875: TM-score 0.99, RMSD 0.51 Å
- 7V31 chain i against the predicted model O79875: TM-score 0.99, RMSD 0.51 Å
- 7V31 chain i against the predicted model O79875: TM-score 0.99, RMSD 0.51 Å
- 7W1V chain i against the predicted model O79875: TM-score 0.99, RMSD 0.51 Å
- 7V2R chain i against the predicted model O79875: TM-score 0.99, RMSD 0.51 Å
- 7V2R chain i against the predicted model O79875: TM-score 0.99, RMSD 0.51 Å
Elsewhere
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