UniProt O75908
Sterol O-acyltransferase 2 (O75908)
Sterol O-acyltransferase 2 (UniProt O75908), EC 2.3.1.26: 4 experimental structures and 1 predicted model on GenesisL1, 4 ligands bound, 44 pockets. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.
- UniProt
- O75908
- Protein
- Sterol O-acyltransferase 2
- EC
- 2.3.1.26
- Experimental structures
- 4
- Predicted models
- 1
- Ligands
- 4
- Pockets
- 44 · 3 records with a druggable one
Structures
5 records of O75908 in the MolNFT archive: 4 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 7N6Q | Structure of PPPA bound human ACAT2 | electron microscopy | A, B, C, D | 7T8, CLR, OLA | 18 (best 0.90) |
| 7N6Q | Structure of pppa bound human ACAT2 | electron microscopy | A, B, C, D | 7T8, CLR, OLA | — |
| 7N6R | Structure of nevanimibe bound human ACAT2 | electron microscopy | A, B, C, D | ROV, CLR, OLA | 18 (best 0.90) |
| 7N6R | Structure of nevanimibe bound human ACAT2 | electron microscopy | A, B, C, D | ROV, CLR, OLA | — |
| O75908 | AlphaFold monomer V2.0 prediction for sterol O-acyltransferase 2 (O75908) | predicted | A | — | 8 (best 0.87) |
Ligands
- CLR · Cholesterol · in 4 records
- OLA · Oleic acid · in 4 records
- 7T8 · (3s,4r,4ar,6s,6as,12r,12as,12bs)-4-[(acetyloxy)methyl]-12-hydroxy-4,6A,12B-trimethyl-11-oxo-9-(pyridin-3-yl)-1,3,4,4A,5,6,6A,12,12A,12B-decahydro-2H,11H-naphtho[2, 1-b]pyrano[3,4-e]pyran-3,6-diyl diacetate · in 2 records
- ROV · nevanimibe · in 2 records
Experiment against prediction
- 7N6R chain A against the predicted model O75908: TM-score 0.98, RMSD 1.09 Å
- 7N6R chain A against the predicted model O75908: TM-score 0.98, RMSD 1.09 Å
- 7N6Q chain A against the predicted model O75908: TM-score 0.97, RMSD 1.29 Å
- 7N6Q chain A against the predicted model O75908: TM-score 0.97, RMSD 1.29 Å
Elsewhere
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