MolNFT v1 · #182859 · protein

Structure of nevanimibe bound human ACAT2

7N6R: “Structure of nevanimibe bound human ACAT2”. Electron microscopy, 3 ligands (CLR, ROV, OLA). MolNFT v1 #182859 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 7N6R
Type: protein
Length: 1,500 residues
Chains: 4
Method: electron microscopy
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
UniProt: O75908
Ligands: CLR, ROV, OLA

Structure

electron microscopy · 1 distinct chain.

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A, B, C, D	—	protein	375	—	O75908

Ligands and binding sites

CLR · Cholesterol · ligand · 8 copies · chains A, B, C, D
ROV · nevanimibe · ligand · 4 copies · chains A, B, C, D
OLA · Oleic acid · ligand · 4 copies · chains A, B, C, D

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Compared structures

7N6R · Structure of nevanimibe bound human ACAT2 · the same entry in another collection · chain A against A, TM-score 1.00
O75908 · AlphaFold monomer V2.0 prediction for sterol O-acyltransferase 2 (O75908) · a predicted model of the same protein · chain A against A, TM-score 0.98

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt O75908
Elsewhere: RCSB PDB 7N6R · PDBe 7N6R · UniProt O75908

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