UniProt O60566
Mitotic checkpoint serine/threonine-protein kinase BUB1 beta (O60566)
Mitotic checkpoint serine/threonine-protein kinase BUB1 beta (UniProt O60566), EC 2.7.11.1: 14 experimental structures and 1 predicted model on GenesisL1, 3 pockets. Binding sites, druggability and experiment against prediction…
- UniProt
- O60566
- Protein
- Mitotic checkpoint serine/threonine-protein kinase BUB1 beta
- EC
- 2.7.11.1
- Experimental structures
- 14
- Predicted models
- 1
- Pockets
- 3 · 2 records with a druggable one
Structures
15 records of O60566 in the MolNFT archive: 14 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 2WVI | Crystal Structure of the N-terminal Domain of BubR1 | x-ray diffraction | A | — | — |
| 2WVI | Crystal structure of the N-terminal domain of BUBR1 | x-ray diffraction | A | — | — |
| 3SI5 | Kinetochore-BUBR1 kinase complex | x-ray diffraction | A, B | — | — |
| 3SI5 | Kinetochore-BUBR1 kinase complex | x-ray diffraction | A, B | — | — |
| 4GGD | Structural analysis of human Cdc20 supports multisite degron recognition by APC/C. | x-ray diffraction | C, D | — | — |
| 4GGD | Structural analysis of human CDC20 supports multisite degron recognition by APC/C. | x-ray diffraction | C, D | — | — |
| 5JJA | Crystal structure of a PP2A B56gamma/BubR1 complex | x-ray diffraction | C, D | — | — |
| 5JJA | Crystal structure of a PP2A B56GAMMA/BUBR1 complex | x-ray diffraction | C, D | — | — |
| 5KHU | Model of human Anaphase-promoting complex/Cyclosome (APC15 deletion mutant), in complex with the… | electron microscopy | Q | — | — |
| 5KHU | Model of human anaphase-promoting COMPLEX/CYCLOSOME (APC15 deletion mutant), in complex with the… | electron microscopy | Q | — | — |
| 5LCW | Cryo-EM structure of the Anaphase-promoting complex/Cyclosome, in complex with the Mitotic… | electron microscopy | S | — | 2 (best 0.84) |
| 5LCW | Cryo-EM structure of the anaphase-promoting COMPLEX/CYCLOSOME, in complex with the mitotic… | electron microscopy | S | — | — |
| 6TLJ | Cryo-EM structure of the Anaphase-promoting complex/Cyclosome, in complex with the Mitotic… | electron microscopy | S | — | 1 (best 0.87) |
| 6TLJ | Cryo-EM structure of the anaphase-promoting COMPLEX/CYCLOSOME, in complex with the mitotic… | electron microscopy | S | — | — |
| O60566 | AlphaFold monomer V2.0 prediction for mitotic checkpoint SERINE/THREONINE-protein kinase BUB1 beta… | predicted | A | — | — |
Experiment against prediction
- 3SI5 chain B against the predicted model O60566: TM-score 0.98, RMSD 0.66 Å
- 3SI5 chain B against the predicted model O60566: TM-score 0.98, RMSD 0.66 Å
- 2WVI chain A against the predicted model O60566: TM-score 0.96, RMSD 1.30 Å
- 2WVI chain A against the predicted model O60566: TM-score 0.96, RMSD 1.30 Å
- 3SI5 chain A against the predicted model O60566: TM-score 0.95, RMSD 1.18 Å
- 3SI5 chain A against the predicted model O60566: TM-score 0.95, RMSD 1.18 Å
- 5KHU chain Q against the predicted model O60566: TM-score 0.87, RMSD 2.70 Å
- 5KHU chain Q against the predicted model O60566: TM-score 0.87, RMSD 2.70 Å
- 5LCW chain S against the predicted model O60566: TM-score 0.82, RMSD 3.19 Å
- 5LCW chain S against the predicted model O60566: TM-score 0.82, RMSD 3.19 Å
Elsewhere
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