MolNFT v1 · #123419 · protein
Crystal structure of a PP2A B56GAMMA/BUBR1 complex
5JJA · SERINE/THREONINE-protein phosphatase 2A 56 kda regulatory…: “Crystal structure of a PP2A B56GAMMA/BUBR1 complex”. X-ray diffraction, 4 pockets (best druggability 0.66). MolNFT v1 #123419 on GenesisL1: 3D structure, binding sites and…
- PDB
- 5JJA
- Type
- protein
- Length
- 682 residues
- Chains
- 4
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- SERINE/THREONINE-protein phosphatase 2A 56 kda regulatory subunit gamma isoform; Mitotic…
- EC
- 2.7.11.1
- UniProt
- Q13362, O60566
- Pockets
- 4 · best druggability 0.66
Structure
x-ray diffraction · 3 distinct chains · 70% helix, 0% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | SERINE/THREONINE-protein phosphatase 2A 56 kda regulatory subunit gamma isoform | protein | 333 | 71% helix, 0% strand | Q13362 |
| B | SERINE/THREONINE-protein phosphatase 2A 56 kda regulatory subunit gamma isoform | protein | 333 | 71% helix, 0% strand | Q13362 |
| C, D | Mitotic checkpoint SERINE/THREONINE-protein kinase BUB1 beta (EC 2.7.11.1) | protein | 8 | 0% helix, 0% strand | O60566 |
Pockets
4 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 466 | 0.66 | 0.78 | 51 | empty |
| 2 | 176 | 0.45 | 0.74 | 24 | empty |
| 3 | 89 | 0.42 | 0.78 | 18 | empty |
| 4 | 55 | 0.30 | 0.76 | 10 | empty |
Interfaces
3 interfaces between chains.
- A–B · 679 Ų buried · 7 hydrogen bonds · protein-protein
- B–D · 574 Ų buried · 8 hydrogen bonds · protein-protein
- A–C · 573 Ų buried · 7 hydrogen bonds · protein-protein
Compared structures
- 5JJA · Crystal structure of a PP2A B56gamma/BubR1 complex · the same entry in another collection · chain D against D, TM-score 1.00
- Q13362 · AlphaFold monomer V2.0 prediction for SERINE/THREONINE-protein phosphatase 2A 56 kda… · a predicted model of the same protein · chain A against A, TM-score 0.98
- O60566 · AlphaFold monomer V2.0 prediction for mitotic checkpoint SERINE/THREONINE-protein kinase… · a predicted model of the same protein · chain C against A, TM-score 0.49
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q13362
- Every structure of UniProt O60566
- Elsewhere: RCSB PDB 5JJA · PDBe 5JJA · UniProt Q13362 · UniProt O60566
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