MolNFT v1 · #92696 · protein
Structural analysis of human CDC20 supports multisite degron recognition by APC/C.
4GGD · Cell division cycle protein 20 homolog: “Structural analysis of human CDC20 supports multisite degron recognition by APC/C.”. X-ray diffraction, 4 pockets (best druggability 0.72). MolNFT v1 #92696 on GenesisL1: 3D structure…
- PDB
- 4GGD
- Type
- protein
- Length
- 639 residues
- Chains
- 4
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Cell division cycle protein 20 homolog; Mitotic checkpoint SERINE/THREONINE-protein…
- EC
- 2.7.11.1
- UniProt
- Q12834, O60566
- Pockets
- 4 · best druggability 0.72
Structure
x-ray diffraction · 3 distinct chains · 1% helix, 50% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B | Cell division cycle protein 20 homolog | protein | 312 | 0% helix, 52% strand | Q12834 |
| C | Mitotic checkpoint SERINE/THREONINE-protein kinase BUB1 beta (EC 2.7.11.1) | protein | 7 | 0% helix, 0% strand | O60566 |
| D | Mitotic checkpoint SERINE/THREONINE-protein kinase BUB1 beta (EC 2.7.11.1) | protein | 8 | 38% helix, 0% strand | O60566 |
Pockets
4 pockets found on a 1 Å grid, 3 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 549 | 0.72 | 0.80 | 47 | empty |
| 2 | 531 | 0.71 | 0.80 | 41 | empty |
| 3 | 477 | 0.60 | 0.75 | 55 | empty |
| 4 | 60 | 0.43 | 0.82 | 16 | empty |
Interfaces
4 interfaces between chains.
- B–D · 362 Ų buried · 13 hydrogen bonds · protein-protein
- A–C · 339 Ų buried · 12 hydrogen bonds · protein-protein
- A–B · 135 Ų buried · 2 hydrogen bonds · protein-protein
- A–D · 75 Ų buried · 0 hydrogen bonds · protein-protein
Compared structures
- 4GGD · Structural analysis of human Cdc20 supports multisite degron recognition by APC/C. · the same entry in another collection · chain D against D, TM-score 1.00
- Q12834 · AlphaFold monomer V2.0 prediction for cell division cycle protein 20 homolog (Q12834) · a predicted model of the same protein · chain B against A, TM-score 1.00
- O60566 · AlphaFold monomer V2.0 prediction for mitotic checkpoint SERINE/THREONINE-protein kinase… · a predicted model of the same protein · chain C against A, TM-score 0.69
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q12834
- Every structure of UniProt O60566
- Elsewhere: RCSB PDB 4GGD · PDBe 4GGD · UniProt Q12834 · UniProt O60566
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