UniProt O60547
GDP-mannose 4,6 dehydratase (O60547)
GDP-mannose 4,6 dehydratase (UniProt O60547), EC 4.2.1.47: 14 experimental structures and 1 predicted model on GenesisL1, 9 ligands bound, 35 pockets. Binding sites, druggability and experiment against prediction (TM-score) in…
- UniProt
- O60547
- Protein
- GDP-mannose 4,6 dehydratase
- EC
- 4.2.1.47
- Experimental structures
- 14
- Predicted models
- 1
- Ligands
- 9
- Pockets
- 35 · 3 records with a druggable one
Structures
15 records of O60547 in the MolNFT archive: 14 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 1T2A | Crystal structure of human GDP-D-mannose 4,6-dehydratase | x-ray diffraction | A, B, C, D | NDP, GDP | 13 (best 0.91) |
| 1T2A | Crystal structure of human GDP-D-mannose 4,6-dehydratase | x-ray diffraction | A, B, C, D | — | — |
| 5IN4 | Crystal Structure of GDP-mannose 4,6 dehydratase bound to a GDP-fucose based inhibitor | x-ray diffraction | A, B, C, D | NAP, GDP, 6CK | — |
| 5IN4 | Crystal structure of GDP-mannose 4,6 dehydratase bound to a GDP-fucose based inhibitor | x-ray diffraction | A, B, C, D | — | — |
| 5IN5 | Crystal Structure of GDP-mannose 4,6 dehydratase in complex with natural inhibitor GDP-Fucose | x-ray diffraction | A, B, C, D | NAP, GDP, GFB | — |
| 5IN5 | Crystal structure of GDP-mannose 4,6 dehydratase in complex with natural inhibitor GDP-fucose | x-ray diffraction | A, B, C, D | — | — |
| 6GPJ | Crystal structure of human GDP-D-mannose 4,6-dehydratase in complex with GDP-4F-Man | x-ray diffraction | A, D, C, B | G4F, NAP | — |
| 6GPJ | Crystal structure of human GDP-D-mannose 4,6-dehydratase in complex with GDP-4F-man | x-ray diffraction | A, D, C, B | G4F, NAP | — |
| 6GPK | Crystal structure of human GDP-D-mannose 4,6-dehydratase (E157Q) in complex with GDP-Man | x-ray diffraction | A, B, C, D | NAP, GDD | — |
| 6GPK | Crystal structure of human GDP-D-mannose 4,6-dehydratase (E157Q) in complex with GDP-man | x-ray diffraction | A, B, C, D | NAP, GDD | — |
| 6GPL | Crystal structure of human GDP-D-mannose 4,6-dehydratase in complex with GDP-4k6d-Man | x-ray diffraction | B, C, D, E | BCN, F7E, NAP | — |
| 6GPL | Crystal structure of human GDP-D-mannose 4,6-dehydratase in complex with GDP-4K6D-man | x-ray diffraction | B, C, D, E | BCN, F7E, NAP | — |
| 6Q94 | Crystal structure of human GDP-D-mannose 4,6-dehydratase (S156D) in complex with GDP-Man | x-ray diffraction | B, A, C, D, E, F, G, H | NAP, GDD | 20 (best 0.91) |
| 6Q94 | Crystal structure of human GDP-D-mannose 4,6-dehydratase (S156D) in complex with GDP-man | x-ray diffraction | B, A, C, D, E, F, G, H | NAP, GDD | — |
| O60547 | AlphaFold monomer V2.0 prediction for GDP-mannose 4,6 dehydratase (O60547) | predicted | A | — | 2 (best 0.80) |
Ligands
- NAP · Nadp nicotinamide-adenine-dinucleotide phosphate · in 10 records
- GDD · Guanosine-5'-diphosphate-alpha-D-mannose · in 4 records
- GDP · Guanosine-5'-diphosphate · in 3 records
- BCN · Bicine · in 2 records
- F7E · [[(2~{R},3~{S},4~{R},5~{R})-5-(2-azanyl-6-oxidanylidene-1~{H}-purin-9-yl)-3,4-bis(oxidanyl) oxolan-2-yl]methoxy-oxidanyl-phosphoryl] [(2~{R}, 3~{S},4~{R},6~{R})-6-methyl-3,4-bis(oxidanyl)-5-oxidanylidene-oxan-2-yl] hydrogen phosphate · in 2 records
- G4F · [[(2~{R},3~{S},4~{R},5~{R})-5-(2-azanyl-6-oxidanylidene-1~{H}-purin-9-yl)-3,4-bis(oxidanyl) oxolan-2-yl]methoxy-oxidanyl-phosphoryl] [(2~{R}, 3~{S},4~{R},5~{S},6~{R})-5-fluoranyl-6-(hydroxymethyl)-3,4-bis(oxidanyl)oxan-2-yl] hydrogen phosphate · in 2 records
- 6CK · [(2R,3S,4R,5R)-5-(2-amino-6-oxo-1,6-dihydro-9H-purin-9-yl)-3,4-dihydroxytetrahydrofuran-2-yl]methyl (2R,3S,4R,5S,6R)-3,4,5-trihydroxy-6-(trifluoromethyl)tetrahydro-2H-pyran-2-yl dihydrogen diphosphate (non-preferred name) · in 1 record
- GFB · Guanosine-5'-diphosphate-beta-L-fucopyranose · in 1 record
- NDP · Nadph dihydro-nicotinamide-adenine-dinucleotide phosphate · in 1 record
Experiment against prediction
- 6GPL chain E against the predicted model O60547: TM-score 1.00, RMSD 0.23 Å
- 6GPL chain E against the predicted model O60547: TM-score 1.00, RMSD 0.23 Å
- 6GPL chain C against the predicted model O60547: TM-score 1.00, RMSD 0.26 Å
- 6GPL chain C against the predicted model O60547: TM-score 1.00, RMSD 0.26 Å
- 6GPJ chain A against the predicted model O60547: TM-score 1.00, RMSD 0.28 Å
- 6GPJ chain A against the predicted model O60547: TM-score 1.00, RMSD 0.28 Å
- 1T2A chain D against the predicted model O60547: TM-score 1.00, RMSD 0.28 Å
- 1T2A chain D against the predicted model O60547: TM-score 1.00, RMSD 0.28 Å
- 6GPL chain B against the predicted model O60547: TM-score 1.00, RMSD 0.28 Å
- 6GPL chain B against the predicted model O60547: TM-score 1.00, RMSD 0.28 Å
Elsewhere
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