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Ligand · GFB

GFB · Guanosine-5'-diphosphate-beta-L-fucopyranose

GFB, Guanosine-5'-diphosphate-beta-L-fucopyranose (C16 H25 N5 O15 P2, 589.3 g/mol), in the MolNFT structures on GenesisL1: bound in 6 records (5 PDB entries). Every binding site with its residues within 4.5 Å, the residues it binds most…

Component
GFB
Formula
C16 H25 N5 O15 P2
Class
ligand
Structures
6
PDB entries
5

Binding sites

GFB in 6 structures; the first of them:

  • 5IN5 · Crystal Structure of GDP-mannose 4,6 dehydratase in complex with natural inhibitor… · GFB A1003 · binds PHE60, THR62, TYR69, ALA74, HIS75, GLU77, LEU82, TYR84 and 7 more
  • 5UXH · Structure of Human POFUT1 in complex with GDP-fucose · GFB A401 · binds GLY42, ARG43, PHE44, GLY45, ASN46, HIS238, LEU239, ARG240 and 14 more
  • 8DTI · Cryo-EM structure of Arabidopsis SPY in complex with GDP-fucose · GFB A1001 · binds SER496, VAL497, ILE592, PRO595, ASN662, LYS665, LYS689, LEU721 and 8 more
  • 8RDH · Crystal structure of UDP-galactose 4-epimerase from Pyrococcus horikoshii with bound NAD… · GFB A402 · binds PRO80, VAL82, ARG83, SER120, SER121, THR122, TYR145, LEU172 and 18 more
  • 5KY3 · Mouse POFUT1 in complex with mouse factor VII EGF1 mutant (T101A) and GDP-fucose · GFB A404 · binds GLY47, ARG48, PHE49, GLY50, ASN51, HIS243, ARG245, ASP249 and 15 more
  • 5UXH · Structure of human POFUT1 in complex with GDP-fucose · GFB A401 · binds GLY42, ARG43, PHE44, GLY45, ASN46, HIS238, ARG240, ASP244 and 11 more

Residues it binds most

ALA 11, ASP 7, PHE 11, TYR 8, ASN 13, THR 13, ARG 11, SER 9, GLY 7, LEU 10 (residue and the binding sites it lines).

Found with

  • NAG · 2-acetamido-2-deoxy-beta-D-glucopyranose
  • GOL · Glycerol
  • GDP · Guanosine-5'-diphosphate
  • NAD · Nicotinamide-adenine-dinucleotide
  • NAP · Nadp nicotinamide-adenine-dinucleotide phosphate

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