UniProt O43292
Glycosylphosphatidylinositol anchor attachment 1 protein (O43292)
Glycosylphosphatidylinositol anchor attachment 1 protein (UniProt O43292): 5 experimental structures and 1 predicted model on GenesisL1, 11 ligands bound, 29 pockets. Binding sites, druggability and experiment against prediction…
- UniProt
- O43292
- Protein
- Glycosylphosphatidylinositol anchor attachment 1 protein
- Experimental structures
- 5
- Predicted models
- 1
- Ligands
- 11
- Pockets
- 29 · 4 records with a druggable one
Structures
6 records of O43292 in the MolNFT archive: 5 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 7W72 | Structure of a human glycosylphosphatidylinositol (GPI) transamidase | electron microscopy | A | NAG | 7 (best 0.86) |
| 7W72 | Structure of a human glycosylphosphatidylinositol (gpi) transamidase | electron microscopy | A | NAG | — |
| 7WLD | Cryo-EM structure of the human glycosylphosphatidylinositol transamidase complex at 2.53 Angstrom… | electron microscopy | G | NAG, Y01, AJP, BJR, PEE, 05E | 8 (best 0.87) |
| 7WLD | Cryo-EM structure of the human glycosylphosphatidylinositol transamidase complex at 2.53 ångström… | electron microscopy | G | NAG, Y01, AJP, BJR, PEE, 05E | — |
| 8IMY | Cryo-EM structure of GPI-T (inactive mutant) with GPI and proULBP2, a proprotein substrate | electron microscopy | G | NAG, AJP, 6OU, Y01, MG, 05E | 8 (best 0.85) |
| O43292 | AlphaFold monomer V2.0 prediction for glycosylphosphatidylinositol anchor attachment 1 protein… | predicted | A | — | 6 (best 0.78) |
Ligands
- NAG · 2-acetamido-2-deoxy-beta-D-glucopyranose · in 5 records
- 05E · 2-azanylethyl [(2~{S},3~{S},4~{S},5~{S},6~{R})-6-(hydroxymethyl)-2,4,5-tris(oxidanyl)oxan-3-yl] hydrogen phosphate · in 3 records
- AJP · Digitonin · in 3 records
- Y01 · Cholesterol hemisuccinate · in 3 records
- BJR · (4S,7R)-7-[(hexadecanoyloxy)methyl]-4-hydroxy-N,N,N-trimethyl-4,9-dioxo-3,5,8-trioxa-4lambda~5~-phosphahexacosan-1-aminium · in 2 records
- DKB · [(2R)-1-[2-azanylethoxy(oxidanyl)phosphoryl]oxy-3-hexadecanoyloxy-propan-2-yl] octadecanoate · in 2 records
- PEE · 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine · in 2 records
- 6OU · [(2~{R})-1-[2-azanylethoxy(oxidanyl)phosphoryl]oxy-3-hexadecanoyloxy-propan-2-yl] (~{Z})-octadec-9-enoate · in 1 record
- 80Y · 2-azanylethyl [(2R,3S,4S,5S,6S)-3,4,5,6-tetrakis(oxidanyl)oxan-2-yl]methyl hydrogen phosphate · in 1 record
- 81Q · [(2R)-1-[[(1S,2R,3R,4S,5S,6R)-2-hexadecanoyloxy-3,4,5,6-tetrakis(oxidanyl)cyclohexyl]oxy-oxidanyl-phosphoryl]oxy-3-octadecoxy-propan-2-yl] (5Z,8Z,11Z,14Z)-icosa-5,8,11,14-tetraenoate · in 1 record
- MG · Magnesium ion · in 1 record
Experiment against prediction
- 7W72 chain A against the predicted model O43292: TM-score 0.98, RMSD 1.12 Å
- 7W72 chain A against the predicted model O43292: TM-score 0.98, RMSD 1.12 Å
- 8IMY chain G against the predicted model O43292: TM-score 0.98, RMSD 1.17 Å
- 7WLD chain G against the predicted model O43292: TM-score 0.97, RMSD 1.51 Å
- 7WLD chain G against the predicted model O43292: TM-score 0.97, RMSD 1.51 Å
- 8IMY chain G against the predicted model Q9U6Y3: TM-score 0.15, RMSD 6.54 Å
Elsewhere
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