UniProt O28028
Coenzyme F420:L-glutamate ligase (O28028)
Coenzyme F420:L-glutamate ligase (UniProt O28028), EC 6.3.2.31, 6.3.2.34: 7 experimental structures and 1 predicted model on GenesisL1, 7 ligands bound, 5 pockets. Binding sites, druggability and experiment against prediction…
- UniProt
- O28028
- Protein
- Coenzyme F420:L-glutamate ligase
- EC
- 6.3.2.31, 6.3.2.34
- Experimental structures
- 7
- Predicted models
- 1
- Ligands
- 7
- Pockets
- 5 · 2 records with a druggable one
Structures
8 records of O28028 in the MolNFT archive: 7 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 2G9I | Crystal structure of homolog of F420-0:gamma-Glutamyl Ligase from Archaeoglobus fulgidus Reveals a… | x-ray diffraction | A, B | — | — |
| 2G9I | Crystal structure of homolog of F420-0:GAMMA-glutamyl ligase from archaeoglobus fulgidus reveals a… | x-ray diffraction | A, B | — | — |
| 2PHN | Crystal structure of an amide bond forming F420-gamma glutamyl ligase from Archaeoglobus fulgidus | x-ray diffraction | A, B | — | — |
| 2PHN | Crystal structure of an amide bond forming F420-gamma glutamyl ligase from archaeoglobus fulgidus | x-ray diffraction | A, B | — | — |
| 7ULE | F420-1/GDP complex of F420-gamma glutamyl ligase (CofE) from Archaeoglobus fulgidus | x-ray diffraction | A | GDP, F4I, MN, NA | 3 (best 0.62) |
| 7ULF | l-glutamate/GTP complex of F420-gamma glutamyl ligase (CofE) from Archaeoglobus fulgidus | x-ray diffraction | A | GTP, MN | — |
| 8G8P | F420-2/GTP(GDP) complex of F420-gamma glutamyl ligase (CofE) from Archaeoglobus fulgidus | x-ray diffraction | AAA | F42, GTP, GDP, MN, NA, SO4 | 2 (best 0.69) |
| O28028 | AlphaFold monomer V2.0 prediction for coenzyme F420:L-glutamate ligase (O28028) | predicted | A | — | — |
Ligands
- MN · Manganese (II) ion · in 3 records
- GDP · Guanosine-5'-diphosphate · in 2 records
- GTP · Guanosine-5'-triphosphate · in 2 records
- NA · Sodium ion · in 2 records
- F42 · Coenzyme F420 · in 1 record
- F4I · (2~{S})-2-[[(2~{S})-2-[oxidanyl-[(2~{R},3~{S},4~{S})-2,3,4-tris(oxidanyl)-5-[2,4,8-tris(oxidanylidene)-1,9-dihydropyrimido[4,5-b]quinolin-10-yl]pentoxy]phosphoryl]oxypropanoyl]amino]pentanedioic acid · in 1 record
- SO4 · Sulfate ion · in 1 record
Experiment against prediction
- 7ULE chain A against the predicted model O28028: TM-score 0.99, RMSD 0.59 Å
- 2G9I chain A against the predicted model O28028: TM-score 0.99, RMSD 0.61 Å
- 2G9I chain A against the predicted model O28028: TM-score 0.99, RMSD 0.61 Å
- 2G9I chain B against the predicted model O28028: TM-score 0.99, RMSD 0.65 Å
- 2G9I chain B against the predicted model O28028: TM-score 0.99, RMSD 0.65 Å
- 8G8P chain AAA against the predicted model O28028: TM-score 0.99, RMSD 0.68 Å
- 2PHN chain A against the predicted model O28028: TM-score 0.98, RMSD 0.76 Å
- 2PHN chain A against the predicted model O28028: TM-score 0.98, RMSD 0.76 Å
- 7ULF chain A against the predicted model O28028: TM-score 0.98, RMSD 0.71 Å
- 2PHN chain B against the predicted model O28028: TM-score 0.98, RMSD 0.86 Å
Elsewhere
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