UniProt O25896
Nickel-responsive regulator (O25896)
Nickel-responsive regulator (UniProt O25896): 24 experimental structures and 1 predicted model on GenesisL1, 2 ligands bound, 12 pockets. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.
- UniProt
- O25896
- Protein
- Nickel-responsive regulator
- Experimental structures
- 24
- Predicted models
- 1
- Ligands
- 2
- Pockets
- 12 · 1 record with a druggable one
Structures
25 records of O25896 in the MolNFT archive: 24 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 2CA9 | apo-NIKR from helicobacter pylori in closed trans-conformation | x-ray diffraction | A, B | — | — |
| 2CA9 | Apo-nikr from helicobacter pylori in closed trans- conformation | x-ray diffraction | A, B | — | — |
| 2CAD | NikR from Helicobacter pylori in closed trans-conformation and nickel bound to 2F, 2X and 2I sites. | x-ray diffraction | A, B | — | — |
| 2CAD | Nikr from helicobacter pylori in closed trans-conformation and nickel bound to 2F, 2X and 2I sites. | x-ray diffraction | A, B | — | — |
| 2CAJ | NikR from Helicobacter pylori in closed trans-conformation and nickel bound to 4 intermediary sites | x-ray diffraction | A, B | — | — |
| 2CAJ | Nikr from helicobacter pylori in closed trans-conformation and nickel bound to 4 intermediary sites | x-ray diffraction | A, B | — | — |
| 2WVB | Structural and mechanistic insights into Helicobacter pylori NikR function | x-ray diffraction | A, B | — | — |
| 2WVB | Structural and mechanistic insights into helicobacter pylori nikr function | x-ray diffraction | A, B | — | — |
| 2WVC | Structural and mechanistic insights into Helicobacter pylori NikR function | x-ray diffraction | A, B | — | — |
| 2WVC | Structural and mechanistic insights into helicobacter pylori nikr function | x-ray diffraction | A, B | — | — |
| 2WVD | Structural and mechanistic insights into Helicobacter pylori NikR function | x-ray diffraction | A, B, C, D | — | — |
| 2WVD | Structural and mechanistic insights into helicobacter pylori nikr function | x-ray diffraction | A, B, C, D | — | — |
| 2WVE | Structural and mechanistic insights into Helicobacter pylori NikR function | x-ray diffraction | A, B | — | — |
| 2WVE | Structural and mechanistic insights into helicobacter pylori nikr function | x-ray diffraction | A, B | — | — |
| 2WVF | Structural and mechanistic insights into Helicobacter pylori NikR function | x-ray diffraction | A, B | — | — |
| 2WVF | Structural and mechanistic insights into helicobacter pylori nikr function | x-ray diffraction | A, B | — | — |
| 3LGH | Crystal structure of NikR from Helicobacter pylori with variable Ni site coordination | x-ray diffraction | A, B, C, D | — | — |
| 3LGH | Crystal structure of nikr from helicobacter pylori with variable ni site coordination | x-ray diffraction | A, B, C, D | — | — |
| 3PHT | Crystal structure of H74A mutant of Helicobacter Pylori NikR | x-ray diffraction | A, B | — | — |
| 3PHT | Crystal structure of H74A mutant of helicobacter pylori nikr | x-ray diffraction | A, B | — | — |
| 3QSI | Nickel binding domain of NikR from Helicobacter pylori disclosing partial metal occupancy | x-ray diffraction | B, C, D, A, F, G, H, E, J, I | — | — |
| 3QSI | Nickel binding domain of nikr from helicobacter pylori disclosing partial metal occupancy | x-ray diffraction | B, C, D, A, F, G, H, E, J, I | — | — |
| 6MRJ | Crystal structure of H.pylori NikR in complex with DNA | x-ray diffraction | A, B, C, D | NI, MG | 11 (best 0.73) |
| 6MRJ | Crystal structure of H.PYLORI nikr in complex with DNA | x-ray diffraction | A, B, C, D | NI, MG | — |
| O25896 | AlphaFold monomer V2.0 prediction for putative nickel-responsive regulator (O25896) | predicted | A | — | 1 (best 0.26) |
Ligands
Experiment against prediction
- 3QSI chain C against the predicted model O25896: TM-score 0.98, RMSD 0.51 Å
- 3QSI chain C against the predicted model O25896: TM-score 0.98, RMSD 0.51 Å
- 3QSI chain A against the predicted model O25896: TM-score 0.98, RMSD 0.53 Å
- 3QSI chain A against the predicted model O25896: TM-score 0.98, RMSD 0.53 Å
- 2CAD chain B against the predicted model O25896: TM-score 0.97, RMSD 0.83 Å
- 2CAD chain B against the predicted model O25896: TM-score 0.97, RMSD 0.83 Å
- 2CA9 chain B against the predicted model O25896: TM-score 0.97, RMSD 0.87 Å
- 2CA9 chain B against the predicted model O25896: TM-score 0.97, RMSD 0.87 Å
- 2WVB chain B against the predicted model O25896: TM-score 0.96, RMSD 1.00 Å
- 2WVB chain B against the predicted model O25896: TM-score 0.96, RMSD 1.00 Å
Elsewhere
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