MolNFT v1 · #53459 · protein
Structural and mechanistic insights into helicobacter pylori nikr function
2WVB · Putative nickel-responsive regulator: “Structural and mechanistic insights into helicobacter pylori nikr function”. X-ray diffraction, 1 pocket (best druggability 0.71). MolNFT v1 #53459 on GenesisL1: 3D structure, binding sites and…
- PDB
- 2WVB
- Type
- protein
- Length
- 269 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Putative nickel-responsive regulator
- UniProt
- O25896
- Pockets
- 1 · best druggability 0.71
Structure
x-ray diffraction · 2 distinct chains · 38% helix, 35% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Putative nickel-responsive regulator | protein | 130 | 39% helix, 36% strand | O25896 |
| B | Putative nickel-responsive regulator | protein | 139 | 37% helix, 33% strand | O25896 |
Ligands and binding sites
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
1 pocket found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 710 | 0.71 | 0.77 | 59 | empty |
Interfaces
1 interface between chains.
- A–B · 2720 Ų buried · 35 hydrogen bonds · protein-protein
Compared structures
- 2WVB · Structural and mechanistic insights into Helicobacter pylori NikR function · the same entry in another collection · chain A against A, TM-score 1.00
- O25896 · AlphaFold monomer V2.0 prediction for putative nickel-responsive regulator (O25896) · a predicted model of the same protein · chain B against A, TM-score 0.96
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt O25896
- Elsewhere: RCSB PDB 2WVB · PDBe 2WVB · UniProt O25896
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