UniProt O15294
UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit (O15294)
UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit (UniProt O15294), EC 2.4.1.255: 82 experimental structures on GenesisL1, 18 ligands bound, 245 pockets. Binding sites, pockets, druggability and 3D…
- UniProt
- O15294
- Protein
- UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit
- EC
- 2.4.1.255
- Experimental structures
- 82
- Predicted models
- 0
- Ligands
- 18
- Pockets
- 245 · 22 records with a druggable one
Structures
82 records of O15294 in the MolNFT archive: 82 experimental, 0 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 1W3B | The superhelical TPR domain of O-linked GlcNAc transferase reveals structural similarities to… | x-ray diffraction | A, B | — | — |
| 1W3B | The superhelical tpr domain of O-linked glcnac transferase reveals structural similarities to… | x-ray diffraction | A, B | — | — |
| 3PE3 | Structure of human O-GlcNAc transferase and its complex with a peptide substrate | x-ray diffraction | A, B, C, D | — | — |
| 3PE3 | Structure of human O-glcnac transferase and its complex with a peptide substrate | x-ray diffraction | A, B, C, D | — | — |
| 3PE4 | Structure of human O-GlcNAc transferase and its complex with a peptide substrate | x-ray diffraction | A, C | — | — |
| 3PE4 | Structure of human O-glcnac transferase and its complex with a peptide substrate | x-ray diffraction | A, C | — | — |
| 3TAX | A Neutral Diphosphate Mimic Crosslinks the Active Site of Human O-GlcNAc Transferase | x-ray diffraction | A, C | — | — |
| 3TAX | A neutral diphosphate mimic crosslinks the active site of human O- glcnac transferase | x-ray diffraction | A, C | — | — |
| 4AY5 | Human O-GlcNAc transferase (OGT) in complex with UDP and glycopeptide | x-ray diffraction | A, B, C, D | — | — |
| 4AY5 | Human O-glcnac transferase (ogt) in complex with udp and glycopeptide | x-ray diffraction | A, B, C, D | — | — |
| 4AY6 | Human O-GlcNAc transferase (OGT) in complex with UDP-5SGlcNAc and substrate peptide | x-ray diffraction | A, B, C, D | — | — |
| 4AY6 | Human O-glcnac transferase (ogt) in complex with udp-5SGLCNAC and substrate peptide | x-ray diffraction | A, B, C, D | — | — |
| 4CDR | Human O-GlcNAc transferase in complex with a bisubstrate inhibitor, Goblin1 | x-ray diffraction | A, B, C, D | — | — |
| 4CDR | Human O-glcnac transferase in complex with a bisubstrate inhibitor, GOBLIN1 | x-ray diffraction | A, B, C, D | — | — |
| 4GYW | Crystal structure of human O-GlcNAc Transferase in complex with UDP and a glycopeptide | x-ray diffraction | A, C | — | — |
| 4GYW | Crystal structure of human O-glcnac transferase in complex with udp and a glycopeptide | x-ray diffraction | A, C | — | — |
| 4GYY | Crystal structure of human O-GlcNAc Transferase with UDP-5SGlcNAc and a peptide substrate | x-ray diffraction | A, C | — | — |
| 4GYY | Crystal structure of human O-glcnac transferase with udp-5SGLCNAC and a peptide substrate | x-ray diffraction | A, C | — | — |
| 4GZ3 | Crystal structure of human O-GlcNAc Transferase with UDP and a thioglycopeptide | x-ray diffraction | A, C | — | — |
| 4GZ3 | Crystal structure of human O-glcnac transferase with udp and a thioglycopeptide | x-ray diffraction | A, C | — | — |
| 4GZ5 | Crystal structure of human O-GlcNAc Transferase with UDP-GlcNAc | x-ray diffraction | A, B, C, D | — | — |
| 4GZ5 | Crystal structure of human O-glcnac transferase with udp-glcnac | x-ray diffraction | A, B, C, D | — | — |
| 4GZ6 | Crystal structure of human O-GlcNAc Transferase with UDP-5SGlcNAc | x-ray diffraction | A, B, C, D | — | — |
| 4GZ6 | Crystal structure of human O-glcnac transferase with udp-5SGLCNAC | x-ray diffraction | A, B, C, D | — | — |
| 4N39 | Crystal structure of human O-GlcNAc transferase bound to a peptide from HCF-1 pro-repeat 2 (11-26) | x-ray diffraction | A | — | — |
| 4N39 | Crystal structure of human O-glcnac transferase bound to a peptide from hcf-1 pro-repeat 2 (11-26) | x-ray diffraction | A | — | — |
| 4N3A | Crystal Structure of human O-GlcNAc transferase bound to a peptide from HCF-1 pro-repeat 2… | x-ray diffraction | A | — | — |
| 4N3A | Crystal structure of human O-glcnac transferase bound to a peptide from hcf-1 pro-repeat 2… | x-ray diffraction | A | — | — |
| 4N3B | Crystal Structure of human O-GlcNAc Transferase bound to a peptide from HCF-1 pro-repeat2(1-26)E10Q… | x-ray diffraction | A | — | — |
| 4N3B | Crystal structure of human O-glcnac transferase bound to a peptide from hcf-1 pro-REPEAT2(1-26)E10Q… | x-ray diffraction | A | — | — |
| 4N3C | Crystal Structure of human O-GlcNAc Transferase bound to a peptide from HCF-1 pro-repeat2(1-26) and… | x-ray diffraction | A | — | — |
| 4N3C | Crystal structure of human O-glcnac transferase bound to a peptide from hcf-1 pro-REPEAT2(1-26) and… | x-ray diffraction | A | — | — |
| 4XI9 | Human OGT in complex with UDP-5S-GlcNAc and substrate peptide (RBL2) | x-ray diffraction | A, B, C, D | 12V | 20 (best 0.82) |
| 4XI9 | Human ogt in complex with udp-5S-glcnac and substrate peptide (RBL2) | x-ray diffraction | A, B, C, D | — | — |
| 4XIF | Human OGT in complex with UDP-5S-GlcNAc and substrate peptide (keratin-7) | x-ray diffraction | A, B, C, D | SO4, 12V | 20 (best 0.83) |
| 4XIF | Human ogt in complex with udp-5S-glcnac and substrate peptide (keratin-7) | x-ray diffraction | A, B, C, D | — | — |
| 5BNW | The active site of O-GlcNAc transferase imposes constraints on substrate sequence | x-ray diffraction | A | 12V | 7 (best 0.80) |
| 5BNW | The active site of O-glcnac transferase imposes constraints on substrate sequence | x-ray diffraction | A | — | — |
| 5C1D | Human OGT in complex with UDP-5S-GlcNAc and substrate peptide (RB2L) | x-ray diffraction | A | 12V, PO4 | 8 (best 0.77) |
| 5C1D | Human ogt in complex with udp-5S-glcnac and substrate peptide (RB2L) | x-ray diffraction | A | — | — |
| 5HGV | Structure of an O-GlcNAc transferase point mutant, D554N in complex with peptide | x-ray diffraction | A, C | UDP, SO4, NAG | — |
| 5HGV | Structure of an O-glcnac transferase point mutant, D554N in complex with peptide | x-ray diffraction | A, C | — | — |
| 5LVV | Human OGT in complex with UDP and fused substrate peptide (Tab1) | x-ray diffraction | A | UDP, NAG | 5 (best 0.80) |
| 5LVV | Human ogt in complex with udp and fused substrate peptide (TAB1) | x-ray diffraction | A | UDP, NAG | — |
| 5LWV | Human OGT in complex with UDP and fused substrate peptide (HCF1) | x-ray diffraction | A | UDP, PO4 | 8 (best 0.80) |
| 5LWV | Human ogt in complex with udp and fused substrate peptide (HCF1) | x-ray diffraction | A | UDP, PO4 | — |
| 5NPR | The human O-GlcNAc transferase in complex with a thiol-linked bisubstrate inhibitor | x-ray diffraction | A | 94T | — |
| 5NPR | The human O-glcnac transferase in complex with a thiol-linked bisubstrate inhibitor | x-ray diffraction | A | NH2, 94T | — |
| 5NPS | The human O-GlcNAc transferase in complex with a bisubstrate inhibitor | x-ray diffraction | A | 94T | 7 (best 0.79) |
| 5NPS | The human O-glcnac transferase in complex with a bisubstrate inhibitor | x-ray diffraction | A | NH2, 94T | — |
| 5VIE | Electrophilic probes for deciphering substrate recognition by O-GlcNAc transferase | x-ray diffraction | A, C | UDP, 9C1, 9CD | — |
| 5VIE | Electrophilic probes for deciphering substrate recognition by O-glcnac transferase | x-ray diffraction | A, C | UDP, 9C1, 9CD | — |
| 5VIF | Electrophilic probes for deciphering substrate recognition by O-GlcNAc transferase | x-ray diffraction | A | UDP, 9C1 | 6 (best 0.80) |
| 5VIF | Electrophilic probes for deciphering substrate recognition by O-glcnac transferase | x-ray diffraction | A | UDP, 9C1 | — |
| 6E37 | O-GlcNAc Transferase in complex with covalent inhibitor | x-ray diffraction | A | HQV | — |
| 6E37 | O-glcnac transferase in complex with covalent inhibitor | x-ray diffraction | A | HQV | — |
| 6EOU | O-GlcNAc transferase TPR domain with the intellectual disability associated mutation L254F | x-ray diffraction | A | — | 1 (best 0.28) |
| 6EOU | O-glcnac transferase tpr domain with the intellectual disability associated mutation L254F | x-ray diffraction | A | — | — |
| 6IBO | Catalytic deficiency of O-GlcNAc transferase leads to X-linked intellectual disability | x-ray diffraction | A | 12V, PO4 | 7 (best 0.78) |
| 6IBO | Catalytic deficiency of O-glcnac transferase leads to X-linked intellectual disability | x-ray diffraction | A | 12V, PO4 | — |
22 records more on the page itself.
Ligands
- UDP · Uridine-5'-diphosphate · in 11 records
- 12V · (2S,3R,4R,5S,6R)-3-(acetylamino)-4,5-dihydroxy-6-(hydroxymethyl)tetrahydro-2H-thiopyran-2-yl [(2R,3S, 4R,5R)-5-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-3, 4-dihydroxytetrahydrofuran-2-yl]methyl dihydrogen diphosphate · in 8 records
- PO4 · Phosphate ion · in 7 records
- 94T · [[(2~{R},3~{S},4~{R},5~{R})-5-[2,4-bis(oxidanylidene) pyrimidin-1-yl]-3,4-bis(oxidanyl)oxolan-2-yl]methoxy-oxidanyl-phosphoryl] propyl hydrogen phosphate · in 4 records
- 9C1 · 2-{[(2E)-4-chlorobut-2-enoyl]amino}-2-deoxy-beta-D-glucopyranose · in 4 records
- NAG · 2-acetamido-2-deoxy-beta-D-glucopyranose · in 4 records
- UD1 · Uridine-diphosphate-N-acetylglucosamine · in 3 records
- 9CD · 2-{[(2E)-but-2-enoyl]amino}-2-deoxy-beta-D-glucopyranose · in 2 records
- HQV · (2S,3R,4R,5S,6R)-3-[(2E)-but-2-enoylamino]-4,5-dihydroxy-6-(hydroxymethyl)tetrahydro-2H-thiopyran-2-yl [(2R,3S,4R,5R)-5-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-3,4-dihydroxytetrahydrofuran-2-yl]methyl dihydrogen diphosphate (non-preferred name) · in 2 records
- J9S · N-[(2S)-2-(2-methoxyphenyl)-2-{[(2-oxo-1,2-dihydroquinolin-6-yl)sulfonyl]amino}acetyl]-N-[(thiophen-2-yl)methyl]glycine · in 2 records
- J9V · N-[(2R)-2-(2-methoxyphenyl)-2-{[(2-oxo-1,2-dihydroquinolin-6-yl)sulfonyl]amino}acetyl]-N-[(thiophen-2-yl)methyl]glycine · in 2 records
- JA4 · N-[(2R)-2-{[(7-chloro-2-oxo-1,2-dihydroquinolin-6-yl) sulfonyl]amino}-2-(2-methoxyphenyl)acetyl]-N-[(thiophen-2-yl)methyl]glycine · in 2 records
- JA7 · 5-{2-[(1R)-2-{(carboxymethyl)[(thiophen-2-yl) methyl]amino}-2-oxo-1-{[(2-oxo-1,2-dihydroquinolin-6-yl)sulfonyl]amino}ethyl]phenoxy}pentanoic acid · in 2 records
- JAJ · 4-{2-[(1R)-2-{(carboxymethyl)[(thiophen-2-yl) methyl]amino}-2-oxo-1-{[(2-oxo-1,2-dihydroquinolin-6-yl)sulfonyl]amino}ethyl]phenoxy}butanoic acid · in 2 records
- NH2 · Amino group · in 2 records
- SO4 · Sulfate ion · in 2 records
- NG8 · 3-[2,2-bis(fluoranyl)-10,12-dimethyl-1,3-diaza-2$l^{4}-boratricyclo[7.3.0.0^{3,7}]dodeca-4,6,9,11-tetraen-4-yl]-~{N}-ethyl-propanamide · in 1 record
- NJ5 · [[(2~{R},3~{S},4~{R},5~{R})-5-[2,4-bis(oxidanylidene)pyrimidin-1-yl]-3,4-bis(oxidanyl)oxolan-2-yl]methoxy-oxidanyl-phosphoryl] [(2~{R},3~{R},4~{R},5~{S},6~{R})-3-[6-(butanoylamino)hexanoylamino]-6-(hydroxymethyl)-4,5-bis(oxidanyl)oxan-2-yl] hydrogen phosphate · in 1 record
Experiment against prediction
- 5LWV chain A against the predicted model P51610: TM-score 0.23, RMSD 7.87 Å
- 5LWV chain A against the predicted model P51610: TM-score 0.23, RMSD 7.87 Å
Elsewhere
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