UniProt O14936
Peripheral plasma membrane protein CASK (O14936)
Peripheral plasma membrane protein CASK (UniProt O14936), EC 2.7.11.1: 31 experimental structures and 1 predicted model on GenesisL1, 6 ligands bound, 15 pockets. Binding sites, druggability and experiment against prediction…
- UniProt
- O14936
- Protein
- Peripheral plasma membrane protein CASK
- EC
- 2.7.11.1
- Experimental structures
- 31
- Predicted models
- 1
- Ligands
- 6
- Pockets
- 15 · 1 record with a druggable one
Structures
32 records of O14936 in the MolNFT archive: 31 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 1KGD | Crystal Structure of the Guanylate Kinase-like Domain of Human CASK | x-ray diffraction | A | — | — |
| 1KGD | Crystal structure of the guanylate kinase-like domain of human cask | x-ray diffraction | A | — | — |
| 1KWA | Human CASK/LIN-2 PDZ domain | x-ray diffraction | A, B | — | — |
| 1KWA | Human CASK/LIN-2 PDZ domain | x-ray diffraction | A, B | — | — |
| 1ZL8 | NMR structure of L27 heterodimer from C. elegans Lin-7 and H. sapiens Lin-2 scaffold proteins | solution nmr | B | — | — |
| 1ZL8 | NMR structure of L27 heterodimer from C. elegans lin-7 and H. sapiens lin-2 scaffold proteins | solution nmr | B | — | — |
| 3C0G | CASK CaM-Kinase Domain- 3'-AMP complex, P1 form | x-ray diffraction | A, B | — | — |
| 3C0G | Cask cam-kinase domain- 3'-AMP complex, P1 form | x-ray diffraction | A, B | — | — |
| 3C0H | CASK CaM-Kinase Domain- AMPPNP complex, P1 form | x-ray diffraction | A, B | — | — |
| 3C0H | Cask cam-kinase domain- amppnp complex, P1 form | x-ray diffraction | A, B | — | — |
| 3C0I | CASK CaM-Kinase Domain- 3'-AMP complex, P212121 form | x-ray diffraction | A | — | — |
| 3C0I | Cask cam-kinase domain- 3'-AMP complex, P212121 form | x-ray diffraction | A | — | — |
| 3MFR | CASK-4M CaM Kinase Domain, native | x-ray diffraction | A | — | — |
| 3MFR | Cask-4M cam kinase domain, native | x-ray diffraction | A | — | — |
| 3MFS | CASK-4M CaM Kinase Domain, AMPPNP | x-ray diffraction | A | — | — |
| 3MFS | Cask-4M cam kinase domain, amppnp | x-ray diffraction | A | — | — |
| 3MFT | CASK-4M CaM Kinase Domain, Mn2+ | x-ray diffraction | A | — | — |
| 3MFT | Cask-4M cam kinase domain, MN2+ | x-ray diffraction | A | — | — |
| 3MFU | CASK-4M CaM Kinase Domain, AMPPNP-Mn2+ | x-ray diffraction | A | — | — |
| 3MFU | Cask-4M cam kinase domain, amppnp-MN2+ | x-ray diffraction | A | — | — |
| 3TAC | Crystal Structure of the Liprin-alpha/CASK complex | x-ray diffraction | A | — | — |
| 3TAC | Crystal structure of the liprin-ALPHA/CASK complex | x-ray diffraction | A | — | — |
| 6KMH | The crystal structure of CASK/Mint1 complex | x-ray diffraction | A, B | IOD, CL | — |
| 6KMH | The crystal structure of CASK/MINT1 complex | — | — | — | |
| 6NH9 | Crystal structure of a human CALCIUM/CALMODULIN dependent serine protein kinase (cask) PDZ domain | x-ray diffraction | A, B, C | — | — |
| 6NID | Crystal structure of a human CALCIUM/CALMODULIN dependent serine protein kinase (cask) PDZ domain… | x-ray diffraction | A, B, C | — | — |
| 7OAI | Crystal structure of pseudokinase cask in complex with pfe-PKIS12 | x-ray diffraction | A, B, C, D | V5W | — |
| 7OAJ | Crystal structure of pseudokinase cask in complex with compound 7 | x-ray diffraction | A, B, C, D | V6E | — |
| 7OAK | Crystal structure of pseudokinase cask in complex with compound 26 | x-ray diffraction | A, B, C, D | V6B | — |
| 7OAL | Crystal structure of pseudokinase CASK in complex with compound 25 | x-ray diffraction | A, B, C, D | V62 | 15 (best 0.73) |
| 7OAL | Crystal structure of pseudokinase cask in complex with compound 25 | x-ray diffraction | A, B, C, D | V62 | — |
| O14936 | AlphaFold monomer V2.0 prediction for peripheral plasma membrane protein cask (O14936) | predicted | A | — | — |
Ligands
- V62 · 2-[[2,5-bis(bromanyl)-4-methyl-phenyl]methylamino]-4-(cyclohexylamino)-N-[3-(2-oxidanylidene-1,3-oxazolidin-3-yl)propyl]pyrimidine-5-carboxamide · in 2 records
- CL · Chloride ion · in 1 record
- IOD · Iodide ion · in 1 record
- V5W · 4-(cyclopentylamino)-2-[(2,5-dichlorophenyl) methylamino]-N-[3-(2-oxo-1,3-oxazolidin-3-yl) propyl]pyrimidine-5-carboxamide · in 1 record
- V6B · 2-[[2,5-bis(bromanyl)-4-methyl-phenyl]methylamino]-4-(cyclopentylamino)-N-[3-(2-oxidanylidene-1,3-oxazolidin-3-yl)propyl]pyrimidine-5-carboxamide · in 1 record
- V6E · 4-(cyclopentylamino)-2-[(3,4-dichlorophenyl) methylamino]-N-[3-(2-oxidanylidenepyrrolidin-1-yl) propyl]pyrimidine-5-carboxamide · in 1 record
Experiment against prediction
- 3C0H chain A against the predicted model O14936: TM-score 0.99, RMSD 0.70 Å
- 3C0H chain A against the predicted model O14936: TM-score 0.99, RMSD 0.70 Å
- 7OAL chain C against the predicted model O14936: TM-score 0.99, RMSD 0.67 Å
- 7OAL chain C against the predicted model O14936: TM-score 0.99, RMSD 0.67 Å
- 7OAI chain D against the predicted model O14936: TM-score 0.99, RMSD 0.68 Å
- 7OAL chain D against the predicted model O14936: TM-score 0.99, RMSD 0.68 Å
- 7OAL chain D against the predicted model O14936: TM-score 0.99, RMSD 0.68 Å
- 3C0H chain B against the predicted model O14936: TM-score 0.99, RMSD 0.71 Å
- 3C0H chain B against the predicted model O14936: TM-score 0.99, RMSD 0.71 Å
- 7OAL chain A against the predicted model O14936: TM-score 0.99, RMSD 0.69 Å
Elsewhere
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