MolNFT v1 · #71488 · protein

Cask-4M cam kinase domain, native

3MFR · Peripheral plasma membrane protein cask: “Cask-4M cam kinase domain, native”. X-ray diffraction, 1 ligand (ANP), 2 pockets (best druggability 0.68). MolNFT v1 #71488 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 3MFR
Type: protein
Length: 302 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Peripheral plasma membrane protein cask
EC: 2.7.11.1
UniProt: O14936
Ligands: ANP
Pockets: 2 · best druggability 0.68

Structure

x-ray diffraction · 1 distinct chain · 44% helix, 17% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Peripheral plasma membrane protein cask (EC 2.7.11.1)	protein	302	44% helix, 17% strand	O14936

Ligands and binding sites

ANP · Phosphoaminophosphonic acid-adenylate ester · ligand · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

2 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	466	0.68	0.79	44	ANP
2	171	0.44	0.74	25	empty

Compared structures

3MFR · CASK-4M CaM Kinase Domain, native · the same entry in another collection · chain A against A, TM-score 1.00
O14936 · AlphaFold monomer V2.0 prediction for peripheral plasma membrane protein cask (O14936) · a predicted model of the same protein · chain A against A, TM-score 0.98

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt O14936
Elsewhere: RCSB PDB 3MFR · PDBe 3MFR · UniProt O14936

GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.