MolNFT v1 · #158008 · protein
Crystal structure of a human CALCIUM/CALMODULIN dependent serine protein kinase (cask) PDZ domain
6NH9 · Peripheral plasma membrane protein cask: “Crystal structure of a human CALCIUM/CALMODULIN dependent serine protein kinase (cask) PDZ domain”. X-ray diffraction, 1 pocket (best druggability 0.53). MolNFT v1 #158008 on GenesisL1: 3D…
- PDB
- 6NH9
- Type
- protein
- Length
- 257 residues
- Chains
- 3
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Peripheral plasma membrane protein cask
- EC
- 2.7.11.1
- UniProt
- O14936
- Pockets
- 1 · best druggability 0.53
Structure
x-ray diffraction · 2 distinct chains · 18% helix, 40% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B | Peripheral plasma membrane protein cask (EC 2.7.11.1) | protein | 86 | 17% helix, 40% strand | O14936 |
| C | Peripheral plasma membrane protein cask (EC 2.7.11.1) | protein | 85 | 18% helix, 40% strand | O14936 |
Pockets
1 pocket found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 230 | 0.53 | 0.77 | 28 | empty |
Interfaces
2 interfaces between chains.
- A–C · 539 Ų buried · 7 hydrogen bonds · protein-protein
- B–C · 446 Ų buried · 6 hydrogen bonds · protein-protein
Compared structures
- 6NH9 · Crystal structure of a human calcium/calmodulin dependent serine protein kinase (CASK)… · the same entry in another collection · chain A against A, TM-score 1.00
- O14936 · AlphaFold monomer V2.0 prediction for peripheral plasma membrane protein cask (O14936) · a predicted model of the same protein · chain C against A, TM-score 0.95
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt O14936
- Elsewhere: RCSB PDB 6NH9 · PDBe 6NH9 · UniProt O14936
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