UniProt O06961
Propionate kinase (O06961)
Propionate kinase (UniProt O06961), EC 2.7.2.-, 2.7.2.15: 34 experimental structures and 1 predicted model on GenesisL1, 13 ligands bound, 55 pockets. Binding sites, druggability and experiment against prediction (TM-score) in…
- UniProt
- O06961
- Protein
- Propionate kinase
- EC
- 2.7.2.-, 2.7.2.15
- Experimental structures
- 34
- Predicted models
- 1
- Ligands
- 13
- Pockets
- 55 · 20 records with a druggable one
Structures
35 records of O06961 in the MolNFT archive: 34 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 1X3M | Crystal structure of ADP bound Propionate kinase (TdcD) from Salmonella typhimurium | x-ray diffraction | A | ADP | 3 (best 0.60) |
| 1X3M | Crystal structure of ADP bound propionate kinase (tdcd) from salmonella typhimurium | x-ray diffraction | A | ADP | 3 (best 0.60) |
| 1X3N | Crystal structure of AMPPNP bound Propionate kinase (TdcD) from Salmonella typhimurium | x-ray diffraction | A | ANP | 3 (best 0.60) |
| 1X3N | Crystal structure of amppnp bound propionate kinase (tdcd) from salmonella typhimurium | x-ray diffraction | A | ANP | 3 (best 0.60) |
| 2E1Y | Crystal structure of propionate kinase (TdcD) from Salmonella typhimurium | x-ray diffraction | A | — | 2 (best 0.58) |
| 2E1Y | Crystal structure of propionate kinase (tdcd) from salmonella typhimurium | x-ray diffraction | A | — | — |
| 2E1Z | Crystal structure of Salmonella typhimurium propionate kinase (TdcD) in complex with diadenosine… | x-ray diffraction | A | B4P | 2 (best 0.62) |
| 2E1Z | Crystal structure of salmonella typhimurium propionate kinase (tdcd) in complex with diadenosine… | x-ray diffraction | A | — | — |
| 2E20 | Crystal structure of Salmonella typhimurium propionate kinase (TdcD) in complex with diadenosine… | x-ray diffraction | A | B4P | 3 (best 0.64) |
| 2E20 | Crystal structure of salmonella typhimurium propionate kinase (tdcd) in complex with diadenosine… | x-ray diffraction | A | — | — |
| 4FWK | Crystal structure of Salmonella typhimurium propionate kinase (TdcD) in complex with AMP | x-ray diffraction | A | AMP | 2 (best 0.66) |
| 4FWK | Crystal structure of salmonella typhimurium propionate kinase (tdcd) in complex with AMP | x-ray diffraction | A | — | — |
| 4FWL | Crystal structure of Salmonella typhimurium propionate kinase (TdcD) in complex with Phosphate (PO4) | x-ray diffraction | A | PO4 | 2 (best 0.58) |
| 4FWL | Crystal structure of salmonella typhimurium propionate kinase (tdcd) in complex with phosphate (PO4) | x-ray diffraction | A | — | — |
| 4FWM | Crystal structure of Salmonella typhimurium propionate kinase (TdcD) in complex with ATP | x-ray diffraction | A | ATP | 3 (best 0.58) |
| 4FWM | Crystal structure of salmonella typhimurium propionate kinase (tdcd) in complex with ATP | x-ray diffraction | A | — | — |
| 4FWN | Crystal structure of Salmonella typhimurium propionate kinase (TdcD) in complex with Adenosine… | x-ray diffraction | A | AQP | 4 (best 0.63) |
| 4FWN | Crystal structure of salmonella typhimurium propionate kinase (tdcd) in complex with adenosine… | x-ray diffraction | A | — | — |
| 4FWO | Crystal structure of Salmonella typhimurium propionate kinase (TdcD) in complex with GMP | x-ray diffraction | A | 5GP | 2 (best 0.70) |
| 4FWO | Crystal structure of salmonella typhimurium propionate kinase (tdcd) in complex with gmp | x-ray diffraction | A | — | — |
| 4FWP | Crystal structure of Salmonella typhimurium propionate kinase (TdcD) in complex with GDP | x-ray diffraction | A | GDP | 2 (best 0.59) |
| 4FWP | Crystal structure of salmonella typhimurium propionate kinase (tdcd) in complex with GDP | x-ray diffraction | A | — | — |
| 4FWQ | Crystal structure of Salmonella typhimurium propionate kinase (TdcD) in complex with GTP | x-ray diffraction | A | GTP | 4 (best 0.64) |
| 4FWQ | Crystal structure of salmonella typhimurium propionate kinase (tdcd) in complex with GTP | x-ray diffraction | A | — | — |
| 4FWR | Crystal structure of Salmonella typhimurium propionate kinase (TdcD) in complex with CMP | x-ray diffraction | A | C5P | 1 (best 0.65) |
| 4FWR | Crystal structure of salmonella typhimurium propionate kinase (tdcd) in complex with cmp | x-ray diffraction | A | — | — |
| 4FWS | Crystal structure of Salmonella typhimurium propionate kinase (TdcD) in complex with CTP | x-ray diffraction | A | CTP | 3 (best 0.68) |
| 4FWS | Crystal structure of salmonella typhimurium propionate kinase (tdcd) in complex with CTP | x-ray diffraction | A | — | — |
| 4XH1 | Crystal structure of Salmonella typhimurium propionate kinase in complex with AMPPNP and propionate | x-ray diffraction | A | ANP | 3 (best 0.55) |
| 4XH1 | Crystal structure of salmonella typhimurium propionate kinase in complex with amppnp and propionate | x-ray diffraction | A | — | — |
| 4XH4 | Crystal structure of Salmonella typhimurium propionate kinase A88V mutant, in complex with AMPPNP… | x-ray diffraction | A | ANP, SO4 | 4 (best 0.57) |
| 4XH4 | Crystal structure of salmonella typhimurium propionate kinase A88V mutant, in complex with amppnp… | x-ray diffraction | A | — | — |
| 4XH5 | Crystal structure of Salmonella typhimurium propionate kinase A88G mutant, in complex with AMPPNP… | x-ray diffraction | A | SO4, ANP | 3 (best 0.60) |
| 4XH5 | Crystal structure of salmonella typhimurium propionate kinase A88G mutant, in complex with amppnp… | x-ray diffraction | A | — | — |
| O06961 | AlphaFold monomer V2.0 prediction for propionate kinase (O06961) | predicted | A | — | 3 (best 0.65) |
Ligands
- ANP · Phosphoaminophosphonic acid-adenylate ester · in 5 records
- ADP · Adenosine-5'-diphosphate · in 2 records
- B4P · Bis(adenosine)-5'-tetraphosphate · in 2 records
- SO4 · Sulfate ion · in 2 records
- 5GP · Guanosine-5'-monophosphate · in 1 record
- AMP · Adenosine monophosphate · in 1 record
- AQP · Adenosine-5'-tetraphosphate · in 1 record
- ATP · Adenosine-5'-triphosphate · in 1 record
- C5P · Cytidine-5'-monophosphate · in 1 record
- CTP · Cytidine-5'-triphosphate · in 1 record
- GDP · Guanosine-5'-diphosphate · in 1 record
- GTP · Guanosine-5'-triphosphate · in 1 record
- PO4 · Phosphate ion · in 1 record
Experiment against prediction
- 4FWQ chain A against the predicted model O06961: TM-score 1.00, RMSD 0.30 Å
- 4FWQ chain A against the predicted model O06961: TM-score 1.00, RMSD 0.30 Å
- 2E1Z chain A against the predicted model O06961: TM-score 1.00, RMSD 0.33 Å
- 2E1Z chain A against the predicted model O06961: TM-score 1.00, RMSD 0.33 Å
- 1X3M chain A against the predicted model O06961: TM-score 1.00, RMSD 0.33 Å
- 1X3M chain A against the predicted model O06961: TM-score 1.00, RMSD 0.33 Å
- 4FWM chain A against the predicted model O06961: TM-score 1.00, RMSD 0.34 Å
- 4FWM chain A against the predicted model O06961: TM-score 1.00, RMSD 0.34 Å
- 2E20 chain A against the predicted model O06961: TM-score 1.00, RMSD 0.34 Å
- 2E20 chain A against the predicted model O06961: TM-score 1.00, RMSD 0.34 Å
Elsewhere
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