UniProt O00571
ATP-dependent RNA helicase DDX3X (O00571)
ATP-dependent RNA helicase DDX3X (UniProt O00571), EC 3.6.4.13: 30 experimental structures and 1 predicted model on GenesisL1, 7 ligands bound, 70 pockets. Binding sites, druggability and experiment against prediction (TM-score)…
- UniProt
- O00571
- Protein
- ATP-dependent RNA helicase DDX3X
- EC
- 3.6.4.13
- Experimental structures
- 30
- Predicted models
- 1
- Ligands
- 7
- Pockets
- 70 · 6 records with a druggable one
Structures
31 records of O00571 in the MolNFT archive: 30 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 2I4I | Crystal Structure of human DEAD-box RNA helicase DDX3X | x-ray diffraction | A | — | — |
| 2I4I | Crystal structure of human dead-box RNA helicase DDX3X | x-ray diffraction | A | — | — |
| 2JGN | DDX3 helicase domain | x-ray diffraction | A, B, C | — | — |
| 2JGN | DDX3 helicase domain | x-ray diffraction | A, B, C | — | — |
| 3JRV | Structure of poxvirus K7 protein in complex with RNA helicase DDX3 | x-ray diffraction | C, D, E | — | — |
| 3JRV | Structure of poxvirus K7 protein in complex with RNA helicase DDX3 | x-ray diffraction | C, D, E | — | — |
| 4O2C | An Nt-acetylated peptide complexed with HLA-B*3901 | x-ray diffraction | C | — | — |
| 4O2C | An nt-acetylated peptide complexed with HLA-B*3901 | x-ray diffraction | C | — | — |
| 4O2E | A peptide complexed with HLA-B*3901 | x-ray diffraction | C, F | — | — |
| 4O2E | A peptide complexed with HLA-B*3901 | x-ray diffraction | C, F | — | — |
| 4O2F | A peptide complexed with HLA-B*3901 | x-ray diffraction | C, F | — | — |
| 4O2F | A peptide complexed with HLA-B*3901 | x-ray diffraction | C, F | — | — |
| 4PX9 | DEAD-box RNA helicase DDX3X Domain 1 with N-terminal ATP-binding Loop | x-ray diffraction | A, B, C | — | — |
| 4PX9 | Dead-box RNA helicase DDX3X domain 1 with N-terminal ATP-binding loop | x-ray diffraction | A, B, C | — | — |
| 4PXA | DEAD-box RNA helicase DDX3X Cancer-associated mutant D354V | x-ray diffraction | A | — | — |
| 4PXA | Dead-box RNA helicase DDX3X cancer-associated mutant D354V | x-ray diffraction | A | — | — |
| 5E7I | Crystal structure of the active catalytic core of the human DEAD-box protein DDX3 | x-ray diffraction | B, A, C | — | 20 (best 0.82) |
| 5E7I | Crystal structure of the active catalytic core of the human dead-box protein DDX3 | x-ray diffraction | B, A, C | — | — |
| 5E7J | Crystal structure of the active catalytic core of the human DEAD-box protein DDX3 bound to AMP | x-ray diffraction | A | AMP | 7 (best 0.65) |
| 5E7J | Crystal structure of the active catalytic core of the human dead-box protein DDX3 bound to AMP | x-ray diffraction | A | — | — |
| 5E7M | Crystal structure of the active catalytic core of the human DEAD-box protein DDX3 bound to AMPPNP | x-ray diffraction | A | ANP | — |
| 5E7M | Crystal structure of the active catalytic core of the human dead-box protein DDX3 bound to amppnp | x-ray diffraction | A | — | — |
| 6CZ5 | Crystal structure of small molecule AMP-acrylamide covalently bound to DDX3 S228C | x-ray diffraction | A | FPJ | 5 (best 0.64) |
| 6CZ5 | Crystal structure of small molecule AMP-acrylamide covalently bound to DDX3 S228C | x-ray diffraction | A | FPJ | — |
| 6O5F | Crystal structure of DEAD-box RNA helicase DDX3X at pre-unwound state | x-ray diffraction | A, B | CL | — |
| 6O5F | Crystal structure of dead-box RNA helicase DDX3X at pre-unwound state | x-ray diffraction | A, B | CL | — |
| 7LIU | DDX3X bound to ATP analog and remodeled RNA:DNA hybrid | x-ray diffraction | A, B | MG, 08T | 15 (best 0.75) |
| 7LIU | DDX3X bound to ATP analog and remodeled RNA:DNA hybrid | x-ray diffraction | A, B | MG, 08T | — |
| 7YMF | Crystal Structure of DDX3X449_450ET>DP | x-ray diffraction | A, B | — | 5 (best 0.62) |
| 8SSW | Crystal structure of DEAD-box RNA helicase DDX3X in complex with ADP at pre-unwound state | x-ray diffraction | A, B | ADP, MG | 18 (best 0.78) |
| O00571 | AlphaFold monomer V2.0 prediction for ATP-dependent RNA helicase DDX3X (O00571) | predicted | A | — | — |
Ligands
- MG · Magnesium ion · in 3 records
- 08T · [[[(2R,3S,4R,5R)-5-(6-aminopurin-9-yl)-3,4-bis(oxidanyl)oxolan-2-yl]methoxy-oxidanyl-phosphoryl]oxy-oxidanyl-phosphoryl]oxy-tris(fluoranyl)beryllium · in 2 records
- CL · Chloride ion · in 2 records
- FPJ · 5'-O-[(R)-hydroxy(propanoylamino)phosphoryl]adenosine · in 2 records
- ADP · Adenosine-5'-diphosphate · in 1 record
- AMP · Adenosine monophosphate · in 1 record
- ANP · Phosphoaminophosphonic acid-adenylate ester · in 1 record
Experiment against prediction
- 4PX9 chain B against the predicted model O00571: TM-score 0.98, RMSD 0.74 Å
- 4PX9 chain B against the predicted model O00571: TM-score 0.98, RMSD 0.74 Å
- 4PX9 chain A against the predicted model O00571: TM-score 0.98, RMSD 0.76 Å
- 4PX9 chain A against the predicted model O00571: TM-score 0.98, RMSD 0.76 Å
- 4PX9 chain C against the predicted model O00571: TM-score 0.97, RMSD 0.95 Å
- 4PX9 chain C against the predicted model O00571: TM-score 0.97, RMSD 0.95 Å
- 7LIU chain A against the predicted model O00571: TM-score 0.97, RMSD 1.43 Å
- 7LIU chain A against the predicted model O00571: TM-score 0.97, RMSD 1.43 Å
- 7LIU chain B against the predicted model O00571: TM-score 0.97, RMSD 1.44 Å
- 7LIU chain B against the predicted model O00571: TM-score 0.97, RMSD 1.44 Å
Elsewhere
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