MolNFT v1 · #39766 · protein
Crystal structure of human dead-box RNA helicase DDX3X
2I4I · ATP-dependent RNA helicase DDX3X: “Crystal structure of human dead-box RNA helicase DDX3X”. X-ray diffraction, 1 ligand (AMP), 2 pockets (best druggability 0.67). MolNFT v1 #39766 on GenesisL1: 3D structure, binding sites and…
- PDB
- 2I4I
- Type
- protein
- Length
- 408 residues
- Chains
- 1
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- ATP-dependent RNA helicase DDX3X
- EC
- 3.6.1.-
- UniProt
- O00571
- Ligands
- AMP
- Pockets
- 2 · best druggability 0.67
Structure
x-ray diffraction · 1 distinct chain · 44% helix, 18% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | ATP-dependent RNA helicase DDX3X (EC 3.6.1.-) | protein | 408 | 44% helix, 18% strand | O00571 |
Ligands and binding sites
- AMP · Adenosine monophosphate · ligand · chains A
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
2 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 635 | 0.67 | 0.77 | 60 | AMP |
| 2 | 65 | 0.32 | 0.75 | 20 | empty |
Compared structures
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt O00571
- Elsewhere: RCSB PDB 2I4I · PDBe 2I4I · UniProt O00571
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