UniProt O00444
Serine/threonine-protein kinase PLK4 (O00444)
Serine/threonine-protein kinase PLK4 (UniProt O00444), EC 2.7.11.1, 2.7.11.21: 31 experimental structures and 1 predicted model on GenesisL1, 5 ligands bound, 90 pockets. Binding sites, druggability and experiment against…
- UniProt
- O00444
- Protein
- Serine/threonine-protein kinase PLK4
- EC
- 2.7.11.1, 2.7.11.21
- Experimental structures
- 31
- Predicted models
- 1
- Ligands
- 5
- Pockets
- 90 · 13 records with a druggable one
Structures
32 records of O00444 in the MolNFT archive: 31 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 2N19 | STIL binding to the Polo-box domain 3 of PLK4 regulates centriole duplication | solution nmr | A | — | 1 (best 0.47) |
| 2N19 | Stil binding to the polo-box domain 3 of PLK4 regulates centriole duplication | solution nmr | A | — | 1 (best 0.47) |
| 3COK | Crystal structure of PLK4 kinase | x-ray diffraction | A, B | SO4, ANP | 5 (best 0.66) |
| 3COK | Crystal structure of PLK4 kinase | x-ray diffraction | A, B | SO4, ANP | 5 (best 0.66) |
| 4JXF | Crystal Structure of PLK4 Kinase with an inhibitor: 400631… | x-ray diffraction | A | 631 | 3 (best 0.68) |
| 4JXF | Crystal structure of PLK4 kinase with an inhibitor: 400631 ((1R,2S)-2… | x-ray diffraction | A | — | — |
| 4N7V | Crystal structure of human Plk4 cryptic polo box (CPB) in complex with a Cep152 N-terminal fragment | x-ray diffraction | A, B | — | 5 (best 0.74) |
| 4N7V | Crystal structure of human PLK4 cryptic polo box (cpb) in complex with a CEP152 N-terminal fragment | x-ray diffraction | A, B | — | — |
| 4N7Z | Crystal structure of human Plk4 cryptic polo box (CPB) in complex with a Cep192 N-terminal fragment | x-ray diffraction | A | — | 2 (best 0.50) |
| 4N7Z | Crystal structure of human PLK4 cryptic polo box (cpb) in complex with a CEP192 N-terminal fragment | x-ray diffraction | A | — | — |
| 4N9J | Crystal structure of the cryptic polo box domain of human Plk4 | x-ray diffraction | A, B | CL, SO4 | 3 (best 0.40) |
| 4N9J | Crystal structure of the cryptic polo box domain of human PLK4 | x-ray diffraction | A, B | — | — |
| 4YUR | Crystal Structure of Plk4 Kinase Domain Bound to Centri | x-ray diffraction | A | 4J7 | 2 (best 0.60) |
| 4YUR | Crystal structure of PLK4 kinase domain bound to centrinone | x-ray diffraction | A | — | — |
| 4YYP | Crystal structure of human PLK4-PB3 in complex with STIL-CC | x-ray diffraction | A | CL | 1 (best 0.42) |
| 4YYP | Crystal structure of human PLK4-PB3 in complex with stil-cc | x-ray diffraction | A | — | — |
| 5LHY | PB3 Domain of Human PLK4 (apo) | x-ray diffraction | A, B, C, D, E, F, G, H, I, J, K, L, M, N, O, P, Q, R, S, T, U, V, W, X, Y, Z, 1, 2, 3, 4, 5, 6, 7, 8, 9, a, b, c, d, e, f, g, h, i, j, k, l, m, n, o, p, q, r, s, t, u, v, w, x, y | — | 20 (best 0.90) |
| 5LHY | PB3 domain of human PLK4 (apo) | x-ray diffraction | A, B, C, D, E, F, G, H, I, J, K, L, M, N, O, P, Q, R, S, T, U, V, W, X, Y, Z, 1, 2, 3, 4, 5, 6, 7, 8, 9, a, b, c, d, e, f, g, h, i, j, k, l, m, n, o, p, q, r, s, t, u, v, w, x, y | — | — |
| 5LHZ | PB3 Domain of Human PLK4 in Complex with Coiled-Coil Domain of STIL | x-ray diffraction | A, B, C | — | 2 (best 0.60) |
| 5LHZ | PB3 domain of human PLK4 in complex with coiled-coil domain of stil | x-ray diffraction | A, B, C | — | — |
| 6N45 | Crystal structure of the cryptic polo box domain of human activated Plk4 variant 1 | x-ray diffraction | A, B | — | 2 (best 0.42) |
| 6N45 | Crystal structure of the cryptic polo box domain of human activated PLK4 variant 1 | x-ray diffraction | A, B | — | — |
| 6N46 | Crystal structure of the cryptic polo box domain of a human activated Plk4 | x-ray diffraction | A, B, C, D, E, F, G, H | — | 20 (best 0.76) |
| 6N46 | Crystal structure of the cryptic polo box domain of a human activated PLK4 | x-ray diffraction | A, B, C, D, E, F, G, H | — | — |
| 6W38 | Crystal structure of the FAM46C/Plk4 complex | x-ray diffraction | B | — | 4 (best 0.81) |
| 6W38 | Crystal structure of the FAM46C/PLK4 complex | x-ray diffraction | B | — | — |
| 6W3I | Crystal structure of a FAM46C mutant in complex with Plk4 | x-ray diffraction | B | — | 2 (best 0.78) |
| 6W3I | Crystal structure of a FAM46C mutant in complex with PLK4 | x-ray diffraction | B | — | — |
| 6W3J | Crystal structure of the FAM46C/Plk4/Cep192 complex | x-ray diffraction | B | — | 5 (best 0.81) |
| 6W3J | Crystal structure of the FAM46C/PLK4/CEP192 complex | x-ray diffraction | B | — | — |
| 8XPG | The Crystal Structure of polo box domain of Plk4 from Biortus. | x-ray diffraction | A, B | SO4 | 2 (best 0.40) |
| O00444 | AlphaFold monomer V2.0 prediction for SERINE/THREONINE-protein kinase PLK4 (O00444) | predicted | A | — | 5 (best 0.69) |
Ligands
- SO4 · Sulfate ion · in 4 records
- ANP · Phosphoaminophosphonic acid-adenylate ester · in 2 records
- CL · Chloride ion · in 2 records
- 4J7 · 2-({2-fluoro-4-[(2-fluoro-3-nitrobenzyl)sulfonyl]phenyl}sulfanyl)-5-methoxy-N-(3-methyl-1H-pyrazol-5-yl)-6-(morpholin-4-yl)pyrimidin-4-amine · in 1 record
- 631 · (1R,2S)-2-{3-[(E)-2-{4-[(dimethylamino)methyl]phenyl}ethenyl]-2H-indazol-6-yl}-5'-methoxyspiro[cyclopropane-1,3'-indol]-2'(1'H)-one · in 1 record
Experiment against prediction
- 8XPG chain B against the predicted model O00444: TM-score 0.99, RMSD 0.73 Å
- 8XPG chain A against the predicted model O00444: TM-score 0.98, RMSD 0.77 Å
- 6W3I chain B against the predicted model O00444: TM-score 0.98, RMSD 0.79 Å
- 6W3I chain B against the predicted model O00444: TM-score 0.98, RMSD 0.79 Å
- 6W38 chain B against the predicted model O00444: TM-score 0.97, RMSD 1.00 Å
- 6W38 chain B against the predicted model O00444: TM-score 0.97, RMSD 1.00 Å
- 4N9J chain A against the predicted model O00444: TM-score 0.97, RMSD 1.07 Å
- 4N9J chain A against the predicted model O00444: TM-score 0.97, RMSD 1.07 Å
- 4N7V chain A against the predicted model O00444: TM-score 0.96, RMSD 1.18 Å
- 4N7V chain A against the predicted model O00444: TM-score 0.96, RMSD 1.18 Å
Elsewhere
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