MolNFT v1 · #157585 · protein
Crystal structure of the cryptic polo box domain of a human activated PLK4
6N46 · SERINE/THREONINE-protein kinase PLK4: “Crystal structure of the cryptic polo box domain of a human activated PLK4”. X-ray diffraction, 20 pockets (best druggability 0.76). MolNFT v1 #157585 on GenesisL1: 3D structure, binding sites…
- PDB
- 6N46
- Type
- protein
- Length
- 1,696 residues
- Chains
- 8
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- SERINE/THREONINE-protein kinase PLK4
- EC
- 2.7.11.21
- UniProt
- O00444
- Pockets
- 20 · best druggability 0.76
Structure
x-ray diffraction · 1 distinct chain · 22% helix, 31% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B, C, D, E, F, G, H | SERINE/THREONINE-protein kinase PLK4 (EC 2.7.11.21) | protein | 212 | 22% helix, 31% strand | O00444 |
Pockets
20 pockets found on a 1 Å grid, 5 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 1069 | 0.76 | 0.78 | 84 | empty |
| 2 | 654 | 0.69 | 0.77 | 64 | empty |
| 3 | 519 | 0.66 | 0.77 | 52 | empty |
| 4 | 421 | 0.65 | 0.78 | 41 | empty |
| 5 | 184 | 0.52 | 0.78 | 33 | empty |
Interfaces
14 interfaces between chains.
- C–D · 1009 Ų buried · 8 hydrogen bonds · protein-protein
- A–B · 990 Ų buried · 8 hydrogen bonds · protein-protein
- E–F · 974 Ų buried · 8 hydrogen bonds · protein-protein
- G–H · 961 Ų buried · 5 hydrogen bonds · protein-protein
- B–G · 604 Ų buried · 3 hydrogen bonds · protein-protein
Compared structures
- 6N46 · Crystal structure of the cryptic polo box domain of a human activated Plk4 · the same entry in another collection · chain H against H, TM-score 1.00
- O00444 · AlphaFold monomer V2.0 prediction for SERINE/THREONINE-protein kinase PLK4 (O00444) · a predicted model of the same protein · chain A against A, TM-score 0.94
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt O00444
- Elsewhere: RCSB PDB 6N46 · PDBe 6N46 · UniProt O00444
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