MolNFT v1 · #157584 · protein
Crystal structure of the cryptic polo box domain of human activated PLK4 variant 1
6N45 · Chimera protein of SERINE/THREONINE-protein kinase PLK4 and…: “Crystal structure of the cryptic polo box domain of human activated PLK4 variant 1”. X-ray diffraction, 2 pockets (best druggability 0.42). MolNFT v1 #157584 on…
- PDB
- 6N45
- Type
- protein
- Length
- 407 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Chimera protein of SERINE/THREONINE-protein kinase PLK4 and DDB1- and CUL4-associated…
- EC
- 2.7.11.21, 2.7.11.1
- UniProt
- O00444, Q9Y4B6
- Pockets
- 2 · best druggability 0.42
Structure
x-ray diffraction · 2 distinct chains · 24% helix, 30% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Chimera protein of SERINE/THREONINE-protein kinase PLK4 and DDB1- and CUL4-associated factor 1 (EC 2.7.11.21, 2.7.11.1) | protein | 207 | 25% helix, 30% strand | O00444, Q9Y4B6 |
| B | Chimera protein of SERINE/THREONINE-protein kinase PLK4 and DDB1- and CUL4-associated factor 1 (EC 2.7.11.21, 2.7.11.1) | protein | 200 | 24% helix, 30% strand | O00444, Q9Y4B6 |
Pockets
2 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 108 | 0.42 | 0.77 | 31 | empty |
| 2 | 56 | 0.27 | 0.73 | 15 | empty |
Interfaces
1 interface between chains.
- A–B · 746 Ų buried · 8 hydrogen bonds · protein-protein
Compared structures
- 6N45 · Crystal structure of the cryptic polo box domain of human activated Plk4 variant 1 · the same entry in another collection · chain A against A, TM-score 1.00
- O00444 · AlphaFold monomer V2.0 prediction for SERINE/THREONINE-protein kinase PLK4 (O00444) · a predicted model of the same protein · chain B against A, TM-score 0.96
- Q9Y4B6 · AlphaFold monomer V2.0 prediction for DDB1- and CUL4-associated factor 1 (Q9Y4B6) · a predicted model of the same protein · chain A against A, TM-score 0.33
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt O00444
- Every structure of UniProt Q9Y4B6
- Elsewhere: RCSB PDB 6N45 · PDBe 6N45 · UniProt O00444 · UniProt Q9Y4B6
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