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Ligand · 4J7

4J7 · 2-({2-fluoro-4-[(2-fluoro-3-nitrobenzyl)sulfonyl]phenyl}sulfanyl)-5-methoxy-N-(3-methyl-1H-pyrazol-5-yl)-6-(morpholin-4-yl)pyrimidin-4-amine

4J7, 2-({2-fluoro-4-[(2-fluoro-3-nitrobenzyl)sulfonyl]phenyl}sulfanyl)-5-methoxy-N-(3-methyl-1H-pyrazol-5-yl)-6-(morpholin-4-yl)pyrimidin-4-amine (C26 H25 F2 N7 O6 S2, 633.6 g/mol), in the MolNFT structures on GenesisL1: bound in 2 records…

Component
4J7
Formula
C26 H25 F2 N7 O6 S2
Class
ligand
Structures
2
PDB entries
1

Binding sites

4J7 in 2 structures; the first of them:

  • 4YUR · Crystal Structure of Plk4 Kinase Domain Bound to Centri · 4J7 A1000 · binds LEU18, GLY19, PHE23, ALA24, VAL26, ARG28, ALA39, LYS41 and 11 more
  • 4YUR · Crystal structure of PLK4 kinase domain bound to centrinone · 4J7 A1000 · binds LEU18, GLY19, PHE23, ALA24, VAL26, ARG28, ALA39, LYS41 and 11 more

Residues it binds most

LEU 2, ALA 2, GLY 2, ARG 2, ASN 2, ASP 2, CYS 2, GLU 2, HIS 2, LYS 2 (residue and the binding sites it lines).

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