MolNFT v1 · #100785 · protein
Crystal structure of human PLK4 cryptic polo box (cpb) in complex with a CEP192 N-terminal fragment
4N7Z · SERINE/THREONINE-protein kinase PLK4: “Crystal structure of human PLK4 cryptic polo box (cpb) in complex with a CEP192 N-terminal fragment”. X-ray diffraction, 2 pockets (best druggability 0.50). MolNFT v1 #100785 on GenesisL1: 3D…
- PDB
- 4N7Z
- Type
- protein
- Length
- 248 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- SERINE/THREONINE-protein kinase PLK4; Centrosomal protein of 192 kda
- EC
- 2.7.11.21
- UniProt
- O00444, K7ELX0
- Pockets
- 2 · best druggability 0.50
Structure
x-ray diffraction · 2 distinct chains · 26% helix, 29% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | SERINE/THREONINE-protein kinase PLK4 (EC 2.7.11.21) | protein | 219 | 25% helix, 33% strand | O00444 |
| B | Centrosomal protein of 192 kda | protein | 29 | 34% helix, 0% strand | K7ELX0 |
Pockets
2 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 156 | 0.50 | 0.78 | 29 | empty |
| 2 | 87 | 0.43 | 0.79 | 25 | empty |
Interfaces
1 interface between chains.
- A–B · 1281 Ų buried · 11 hydrogen bonds · protein-protein
Compared structures
- 4N7Z · Crystal structure of human Plk4 cryptic polo box (CPB) in complex with a Cep192… · the same entry in another collection · chain A against A, TM-score 1.00
- O00444 · AlphaFold monomer V2.0 prediction for SERINE/THREONINE-protein kinase PLK4 (O00444) · a predicted model of the same protein · chain A against A, TM-score 0.95
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt O00444
- Every structure of UniProt K7ELX0
- Elsewhere: RCSB PDB 4N7Z · PDBe 4N7Z · UniProt O00444 · UniProt K7ELX0
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