UniProt I3LGP4
DNA-directed RNA polymerase subunit beta (I3LGP4)
DNA-directed RNA polymerase subunit beta (UniProt I3LGP4), EC 2.7.7.6: 62 experimental structures on GenesisL1, 2 ligands bound, 551 pockets. Binding sites, pockets, druggability and 3D structures in GL1X.
- UniProt
- I3LGP4
- Protein
- DNA-directed RNA polymerase subunit beta
- EC
- 2.7.7.6
- Experimental structures
- 62
- Predicted models
- 0
- Ligands
- 2
- Pockets
- 551 · 40 records with a druggable one
Structures
62 records of I3LGP4 in the MolNFT archive: 62 experimental, 0 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 6EXV | Structure of mammalian RNA polymerase II elongation complex inhibited by Alpha-amanitin | electron microscopy | B | ZN | 17 (best 0.87) |
| 6EXV | Structure of mammalian RNA polymerase II elongation complex inhibited by alpha-amanitin | electron microscopy | B | ZN | — |
| 6GMH | Structure of activated transcription complex Pol II-DSIF-PAF-SPT6 | electron microscopy | B | ZN | — |
| 6GMH | Structure of activated transcription complex pol II-dsif-paf-SPT6 | electron microscopy | B | ZN | — |
| 6GML | Structure of paused transcription complex pol II-dsif-nelf | electron microscopy | B | ZN | — |
| 6TED | Structure of complete, activated transcription complex Pol II-DSIF-PAF-SPT6 uncovers allosteric… | electron microscopy | B | ZN | 12 (best 0.89) |
| 6TED | Structure of complete, activated transcription complex pol II-dsif- paf-SPT6 uncovers allosteric… | electron microscopy | B | ZN | — |
| 7NVR | Human Mediator with RNA Polymerase II Pre-initiation complex | electron microscopy | B | ZN | — |
| 7NVR | Human mediator with RNA polymerase II pre-initiation complex | electron microscopy | B | ZN | — |
| 7NVS | RNA polymerase II core pre-initiation complex with closed promoter DNA in proximal position | electron microscopy | B | ZN | 14 (best 0.87) |
| 7NVS | RNA polymerase II core pre-initiation complex with closed promoter DNA in proximal position | electron microscopy | B | ZN | — |
| 7NVT | RNA polymerase II core pre-initiation complex with closed promoter DNA in distal position | electron microscopy | B | ZN | 16 (best 0.87) |
| 7NVT | RNA polymerase II core pre-initiation complex with closed promoter DNA in distal position | electron microscopy | B | ZN | — |
| 7NVU | RNA polymerase II core pre-initiation complex with open promoter DNA | electron microscopy | B | ZN | 16 (best 0.87) |
| 7NVU | RNA polymerase II core pre-initiation complex with open promoter DNA | electron microscopy | B | ZN | — |
| 7NVY | RNA polymerase II pre-initiation complex with closed promoter DNA in proximal position | electron microscopy | B | ZN | 13 (best 0.84) |
| 7NVY | RNA polymerase II pre-initiation complex with closed promoter DNA in proximal position | electron microscopy | B | ZN | — |
| 7NVZ | RNA polymerase II pre-initiation complex with closed promoter DNA in distal position | electron microscopy | B | ZN | — |
| 7NW0 | RNA polymerase II pre-initiation complex with open promoter DNA | electron microscopy | B | ZN | 15 (best 0.84) |
| 7NW0 | RNA polymerase II pre-initiation complex with open promoter DNA | electron microscopy | B | ZN | — |
| 7OKX | Structure of active transcription elongation complex Pol II-DSIF (SPT5-KOW5)-ELL2-EAF1 (composite… | electron microscopy | B | ZN | 15 (best 0.88) |
| 7OKX | Structure of active transcription elongation complex pol II-dsif (SPT5-KOW5)-ELL2-EAF1 (composite… | electron microscopy | B | ZN | — |
| 7OKY | Structure of active transcription elongation complex Pol II-DSIF-ELL2-EAF1(composite structure) | electron microscopy | B | ZN | 16 (best 0.88) |
| 7OKY | Structure of active transcription elongation complex pol II-dsif-ELL2- EAF1(COMPOSITE structure) | electron microscopy | B | ZN | — |
| 7OL0 | Structure of active transcription elongation complex Pol II-DSIF (SPT5-KOW5) | electron microscopy | B | ZN | 15 (best 0.88) |
| 7OL0 | Structure of active transcription elongation complex pol II-dsif (SPT5-KOW5) | electron microscopy | B | ZN | — |
| 7OO3 | Pol II-CSB-CSA-DDB1-UVSSA (Structure1) | electron microscopy | B | ZN | 10 (best 0.88) |
| 7OO3 | Pol II-csb-csa-DDB1-uvssa (STRUCTURE1) | electron microscopy | B | ZN | — |
| 7OOB | Pol II-CSB-CSA-DDB1-UVSSA-ADPBeF3 (Structure2) | electron microscopy | B | ZN | 13 (best 0.87) |
| 7OOB | Pol II-csb-csa-DDB1-uvssa-ADPBEF3 (STRUCTURE2) | electron microscopy | B | ZN | — |
| 7OOP | Pol II-CSB-CSA-DDB1-UVSSA-PAF-SPT6 (Structure 3) | electron microscopy | B | ZN | 10 (best 0.88) |
| 7OOP | Pol II-csb-csa-DDB1-uvssa-paf-SPT6 (structure 3) | electron microscopy | B | ZN | — |
| 7OPC | Pol II-CSB-CRL4CSA-UVSSA-SPT6-PAF (Structure 4) | electron microscopy | B | ZN | 9 (best 0.88) |
| 7OPC | Pol II-csb-CRL4CSA-uvssa-SPT6-paf (structure 4) | electron microscopy | B | ZN | — |
| 7OPD | Pol II-CSB-CRL4CSA-UVSSA-SPT6-PAF (Structure 5) | electron microscopy | B | ZN | 9 (best 0.88) |
| 7OPD | Pol II-csb-CRL4CSA-uvssa-SPT6-paf (structure 5) | electron microscopy | B | ZN | — |
| 7ZWD | Structure of SNAPc containing Pol II pre-initiation complex bound to U5 snRNA promoter (CC) | electron microscopy | B | ZN | 15 (best 0.88) |
| 7ZX7 | Structure of SNAPc containing Pol II pre-initiation complex bound to U1 snRNA promoter (CC) | electron microscopy | B | ZN | 16 (best 0.88) |
| 7ZX8 | Structure of SNAPc containing Pol II pre-initiation complex bound to U1 snRNA promoter (OC) | electron microscopy | B | ZN | 15 (best 0.83) |
| 8A3Y | Structure of mammalian Pol II-DSIF-SPT6-PAF1-TFIIS-hexasome elongation complex | electron microscopy | B | ZN | 12 (best 0.88) |
| 8A40 | Structure of mammalian Pol II-TFIIS elongation complex | electron microscopy | B | ZN, MG | 15 (best 0.89) |
| 8BVW | RNA polymerase II pre-initiation complex with the distal +1 nucleosome (PIC-Nuc18W) | electron microscopy | B | ZN | 10 (best 0.88) |
| 8BYQ | RNA polymerase II pre-initiation complex with the proximal +1 nucleosome (PIC-Nuc10W) | electron microscopy | B | ZN | 10 (best 0.89) |
| 8BZ1 | RNA polymerase II core pre-initiation complex with the proximal +1 nucleosome (cPIC-Nuc10W) | electron microscopy | B | ZN | — |
| 8OEU | Structure of the mammalian Pol II-SPT6 complex (composite structure, Structure 4) | electron microscopy | B | ZN | 16 (best 0.89) |
| 8OEV | Structure of the mammalian Pol II-SPT6-Elongin complex, lacking ELOA latch (composite structure… | electron microscopy | B | ZN | 14 (best 0.88) |
| 8OEW | Structure of the mammalian Pol II-Elongin complex, lacking the ELOA latch (composite structure… | electron microscopy | B | ZN | 15 (best 0.87) |
| 8OF0 | Structure of the mammalian Pol II-SPT6-Elongin complex, Structure 1 | electron microscopy | B | ZN | 13 (best 0.88) |
| 8P4A | Structural insights into human co-transcriptional capping - structure 1 | electron microscopy | B | ZN | 15 (best 0.85) |
| 8P4B | Structural insights into human co-transcriptional capping - structure 2 | electron microscopy | B | ZN | 18 (best 0.85) |
| 8P4C | Structural insights into human co-transcriptional capping - structure 3 | electron microscopy | B | — | 17 (best 0.85) |
| 8P4D | Structural insights into human co-transcriptional capping - structure 4 | electron microscopy | B | — | 17 (best 0.85) |
| 8P4E | Structural insights into human co-transcriptional capping - structure 5 | electron microscopy | B | ZN | 15 (best 0.86) |
| 8P4F | Structural insights into human co-transcriptional capping - structure 6 | electron microscopy | B | ZN | 18 (best 0.89) |
| 8RBX | Structure of Integrator-PP2A bound to a paused RNA polymerase II-DSIF-NELF-nucleosome complex | electron microscopy | B | ZN | 7 (best 0.88) |
| 8S51 | RNA polymerase II core initially transcribing complex with an ordered RNA of 8 nt | electron microscopy | B | ZN | 15 (best 0.85) |
| 8S52 | RNA polymerase II core initially transcribing complex with an ordered RNA of 10 nt | electron microscopy | B | ZN | 14 (best 0.87) |
| 8S54 | RNA polymerase II early elongation complex bound to TFIIE and TFIIF - state b (composite structure) | electron microscopy | B | ZN | 16 (best 0.86) |
| 8S55 | RNA polymerase II early elongation complex bound to TFIIE and TFIIF - state a (composite structure) | electron microscopy | B | ZN | 15 (best 0.87) |
| 8S5N | RNA polymerase II core initially transcribing complex with an ordered RNA of 12 nt | electron microscopy | B | ZN | 14 (best 0.88) |
2 records more on the page itself.
Ligands
Elsewhere
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