UniProt G3X9S2
Ectonucleotide pyrophosphatase/phosphodiesterase 1, isoform CRA_d (G3X9S2)
Ectonucleotide pyrophosphatase/phosphodiesterase 1, isoform CRA_d (UniProt G3X9S2): 14 experimental structures on GenesisL1, 11 ligands bound, 45 pockets. Binding sites, pockets, druggability and 3D structures in GL1X.
- UniProt
- G3X9S2
- Protein
- Ectonucleotide pyrophosphatase/phosphodiesterase 1, isoform CRA_d
- Experimental structures
- 14
- Predicted models
- 0
- Ligands
- 11
- Pockets
- 45 · 3 records with a druggable one
Structures
14 records of G3X9S2 in the MolNFT archive: 14 experimental, 0 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 4GTW | Crystal structure of mouse Enpp1 in complex with AMP | x-ray diffraction | A, B | — | — |
| 4GTW | Crystal structure of mouse ENPP1 in complex with AMP | x-ray diffraction | A, B | — | — |
| 4GTX | Crystal structure of mouse Enpp1 in complex with TMP | x-ray diffraction | A, B | — | — |
| 4GTX | Crystal structure of mouse ENPP1 in complex with tmp | x-ray diffraction | A, B | — | — |
| 4GTY | Crystal structure of mouse Enpp1 in complex with GMP | x-ray diffraction | A, B | — | — |
| 4GTY | Crystal structure of mouse ENPP1 in complex with gmp | x-ray diffraction | A, B | — | — |
| 4GTZ | Crystal structure of mouse Enpp1 in complex with CMP | x-ray diffraction | A, B | — | — |
| 4GTZ | Crystal structure of mouse ENPP1 in complex with cmp | x-ray diffraction | A, B | — | — |
| 6AEK | Crystal structure of ENPP1 in complex with pApG | x-ray diffraction | A | NAG, AMP, 5GP, ZN, CA, CL | 13 (best 0.69) |
| 6AEK | Crystal structure of ENPP1 in complex with papg | x-ray diffraction | A | NAG, A, G, ZN, CA, CL | — |
| 6AEL | Crystal structure of ENPP1 in complex with 3'3'-cGAMP | x-ray diffraction | A | NAG, 4BW, ZN, CA, CL | 12 (best 0.66) |
| 6AEL | Crystal structure of ENPP1 in complex with 3'3'-cgamp | x-ray diffraction | A | NAG, 4BW, ZN, CA, CL | — |
| 6XKD | Structure of ligand-bound mouse cGAMP hydrolase ENPP1 | x-ray diffraction | A, B | NAG, MAN, ZN, CA, CL, IJE | 20 (best 0.78) |
| 6XKD | Structure of ligand-bound mouse cgamp hydrolase ENPP1 | x-ray diffraction | A, B | NAG, ZN, CA, CL, IJE | — |
Ligands
- CA · Calcium ion · in 6 records
- CL · Chloride ion · in 6 records
- NAG · 2-acetamido-2-deoxy-beta-D-glucopyranose · in 6 records
- ZN · Zinc ion · in 6 records
- 4BW · 2-amino-9-[(2r,3r,3as,5r,7ar,9r,10r,10as,12r,14ar)-9-(6-amino-9H-purin-9-yl)-3,5,10,12-tetrahydroxy-5,12-dioxidooctahydro-2H,7H-difuro[3,2-D:3',2'-J][1,3,7,9, 2,8]tetraoxadiphosphacyclododecin-2-yl]-1,9-dihydro-6H-purin-6-one · in 2 records
- IJE · {2-[1-(6,7-dimethoxyquinazolin-4-yl)piperidin-4-yl]ethyl}phosphonic acid · in 2 records
- 5GP · Guanosine-5'-monophosphate · in 1 record
- A · Adenosine-5'-monophosphate · in 1 record
- AMP · Adenosine monophosphate · in 1 record
- G · Guanosine-5'-monophosphate · in 1 record
- MAN · alpha-D-mannopyranose · in 1 record
Experiment against prediction
- 4GTW chain B against the predicted model Q9R1E6: TM-score 0.94, RMSD 1.57 Å
- 4GTW chain B against the predicted model Q9R1E6: TM-score 0.94, RMSD 1.57 Å
- 4GTY chain B against the predicted model Q9R1E6: TM-score 0.94, RMSD 1.57 Å
- 4GTY chain B against the predicted model Q9R1E6: TM-score 0.94, RMSD 1.57 Å
- 4GTZ chain B against the predicted model Q9R1E6: TM-score 0.94, RMSD 1.57 Å
- 4GTZ chain B against the predicted model Q9R1E6: TM-score 0.94, RMSD 1.57 Å
- 4GTX chain B against the predicted model Q9R1E6: TM-score 0.94, RMSD 1.58 Å
- 4GTX chain B against the predicted model Q9R1E6: TM-score 0.94, RMSD 1.58 Å
- 4GTW chain A against the predicted model Q9R1E6: TM-score 0.94, RMSD 1.71 Å
- 4GTW chain A against the predicted model Q9R1E6: TM-score 0.94, RMSD 1.71 Å
Elsewhere
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