UniProt G3I8R9
Endoplasmic reticulum chaperone BiP (G3I8R9)
Endoplasmic reticulum chaperone BiP (UniProt G3I8R9), EC 3.6.4.10: 26 experimental structures and 1 predicted model on GenesisL1, 9 ligands bound, 165 pockets. Binding sites, druggability and experiment against prediction…
- UniProt
- G3I8R9
- Protein
- Endoplasmic reticulum chaperone BiP
- EC
- 3.6.4.10
- Experimental structures
- 26
- Predicted models
- 1
- Ligands
- 9
- Pockets
- 165 · 27 records with a druggable one
Structures
27 records of G3I8R9 in the MolNFT archive: 26 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 5O4P | Crystal structure of AMPylated GRP78 | x-ray diffraction | A, B | SO4, AMP | 8 (best 0.71) |
| 5O4P | Crystal structure of ampylated GRP78 | x-ray diffraction | A, B | SO4, AMP | 8 (best 0.71) |
| 6EOB | Crystal structure of AMPylated GRP78 in apo form (Crystal form 1) | x-ray diffraction | A | PO4 | 3 (best 0.71) |
| 6EOB | Crystal structure of ampylated GRP78 in apo form (crystal form 1) | x-ray diffraction | A | PO4 | 3 (best 0.71) |
| 6EOC | Crystal structure of AMPylated GRP78 in apo form (Crystal form 2) | x-ray diffraction | A | SO4 | 5 (best 0.75) |
| 6EOC | Crystal structure of ampylated GRP78 in apo form (crystal form 2) | x-ray diffraction | A | SO4 | 5 (best 0.75) |
| 6EOE | Crystal structure of AMPylated GRP78 with nucleotide | x-ray diffraction | A | SO4, ADP | 4 (best 0.75) |
| 6EOE | Crystal structure of ampylated GRP78 with nucleotide | x-ray diffraction | A | SO4, ADP | 4 (best 0.75) |
| 6EOF | Crystal structure of AMPylated GRP78 in ADP state | x-ray diffraction | A | ADP, SO4, AMP | 5 (best 0.74) |
| 6EOF | Crystal structure of ampylated GRP78 in ADP state | x-ray diffraction | A | ADP, SO4, AMP | 5 (best 0.74) |
| 6H9U | Crystal structure of the BiP NBD and MANF SAP complex | x-ray diffraction | A | MLT, NA | 6 (best 0.73) |
| 6H9U | Crystal structure of the bip nbd and manf sap complex | x-ray diffraction | A | MLT, NA | 6 (best 0.73) |
| 6HA7 | Crystal structure of the BiP NBD and MANF complex | x-ray diffraction | A, B | — | 9 (best 0.75) |
| 6HA7 | Crystal structure of the bip nbd and manf complex | x-ray diffraction | A, B | — | 9 (best 0.75) |
| 6HAB | Crystal structure of BiP V461F (apo) | x-ray diffraction | A | — | 4 (best 0.76) |
| 6HAB | Crystal structure of bip V461F (apo) | x-ray diffraction | A | — | 4 (best 0.76) |
| 6ZYH | Crystal structure of GRP78 (70kDa heat shock protein 5 / BiP) ATPase domain in complex with ADP and… | x-ray diffraction | A, B | ADP, CA | 5 (best 0.81) |
| 6ZYH | Crystal structure of GRP78 (70KDA heat shock protein 5 / bip) ATPase domain in complex with ADP and… | x-ray diffraction | A, B | ADP, CA | 5 (best 0.81) |
| 7A4U | Crystal structure of lid-truncated apo BiP in an oligomeric state | x-ray diffraction | A | — | 5 (best 0.75) |
| 7A4U | Crystal structure of lid-truncated apo bip in an oligomeric state | x-ray diffraction | A | — | 5 (best 0.75) |
| 7A4V | Crystal structure of lid-truncated ADP-bound BiP in an oligomeric state | x-ray diffraction | A | ADP, K | 5 (best 0.79) |
| 7A4V | Crystal structure of lid-truncated ADP-bound bip in an oligomeric state | x-ray diffraction | A | ADP, K | 5 (best 0.79) |
| 7B7Z | DeAMPylation complex of monomeric FICD and AMPylated BiP (state 1) | x-ray diffraction | B | AMP, MG | 9 (best 0.77) |
| 7B7Z | Deampylation complex of monomeric ficd and ampylated bip (state 1) | x-ray diffraction | B | AMP, MG | 9 (best 0.77) |
| 7B80 | DeAMPylation complex of monomeric FICD and AMPylated BiP (state 2) | x-ray diffraction | B | AMP, MG, PO4, K | 10 (best 0.75) |
| 7B80 | Deampylation complex of monomeric ficd and ampylated bip (state 2) | x-ray diffraction | B | AMP, MG, PO4, K | 10 (best 0.75) |
| G3I8R9 | AlphaFold monomer V2.0 prediction for endoplasmic reticulum chaperone bip (G3I8R9) | predicted | A | — | 9 (best 0.76) |
Ligands
- ADP · Adenosine-5'-diphosphate · in 8 records
- AMP · Adenosine monophosphate · in 8 records
- SO4 · Sulfate ion · in 8 records
- K · Potassium ion · in 4 records
- MG · Magnesium ion · in 4 records
- PO4 · Phosphate ion · in 4 records
- CA · Calcium ion · in 2 records
- MLT · D-malate · in 2 records
- NA · Sodium ion · in 2 records
Experiment against prediction
- 7B7Z chain B against the predicted model G3I8R9: TM-score 0.98, RMSD 1.12 Å
- 7B7Z chain B against the predicted model G3I8R9: TM-score 0.98, RMSD 1.12 Å
- 7B80 chain B against the predicted model G3I8R9: TM-score 0.98, RMSD 1.15 Å
- 7B80 chain B against the predicted model G3I8R9: TM-score 0.98, RMSD 1.15 Å
- 5O4P chain A against the predicted model G3I8R9: TM-score 0.98, RMSD 1.33 Å
- 5O4P chain A against the predicted model G3I8R9: TM-score 0.98, RMSD 1.33 Å
- 6EOB chain A against the predicted model G3I8R9: TM-score 0.97, RMSD 1.37 Å
- 6EOB chain A against the predicted model G3I8R9: TM-score 0.97, RMSD 1.37 Å
- 5O4P chain B against the predicted model G3I8R9: TM-score 0.97, RMSD 1.38 Å
- 5O4P chain B against the predicted model G3I8R9: TM-score 0.97, RMSD 1.38 Å
Elsewhere
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