MolNFT v1 · #172515 · protein

Crystal structure of lid-truncated apo bip in an oligomeric state

7A4U · Endoplasmic reticulum chaperone bip: “Crystal structure of lid-truncated apo bip in an oligomeric state”. X-ray diffraction, 5 pockets (best druggability 0.75). MolNFT v1 #172515 on GenesisL1: 3D structure, binding sites and pockets…

PDB: 7A4U
Type: protein
Length: 523 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Endoplasmic reticulum chaperone bip
EC: 3.6.4.10
UniProt: G3I8R9
Pockets: 5 · best druggability 0.75

Structure

x-ray diffraction · 1 distinct chain · 32% helix, 31% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Endoplasmic reticulum chaperone bip (EC 3.6.4.10)	protein	523	32% helix, 31% strand	G3I8R9

Ligands and binding sites

GOL · Glycerol · additive · 6 copies · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

5 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	384	0.75	0.86	57	GOL
2	354	0.60	0.77	33	empty
3	147	0.50	0.78	21	empty
4	88	0.41	0.78	19	empty
5	58	0.33	0.77	17	empty

Compared structures

7A4U · Crystal structure of lid-truncated apo BiP in an oligomeric state · the same entry in another collection · chain A against A, TM-score 1.00
G3I8R9 · AlphaFold monomer V2.0 prediction for endoplasmic reticulum chaperone bip (G3I8R9) · a predicted model of the same protein · chain A against A, TM-score 0.65

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt G3I8R9
Elsewhere: RCSB PDB 7A4U · PDBe 7A4U · UniProt G3I8R9

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