UniProt F8W4B7
Histone deacetylase 6 (F8W4B7)
Histone deacetylase 6 (UniProt F8W4B7): 42 experimental structures on GenesisL1, 28 ligands bound, 27 pockets. Binding sites, pockets, druggability and 3D structures in GL1X.
- UniProt
- F8W4B7
- Protein
- Histone deacetylase 6
- Experimental structures
- 42
- Predicted models
- 0
- Ligands
- 28
- Pockets
- 27 · 9 records with a druggable one
Structures
42 records of F8W4B7 in the MolNFT archive: 42 experimental, 0 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 5EEF | Crystal structure of Danio rerio histone deacetylase 6 catalytic domain 1 in complex with… | x-ray diffraction | A, B | ZN, TSN, NH4, SO4 | 5 (best 0.67) |
| 5EEF | Crystal structure of danio rerio histone deacetylase 6 catalytic domain 1 in complex with… | x-ray diffraction | A, B | — | — |
| 5G0F | Crystal structure of danio rerio HDAC6 znf-ubp domain | x-ray diffraction | A | — | — |
| 5G0G | Crystal structure of Danio rerio HDAC6 CD1 in complex with trichostatin A | x-ray diffraction | A | ZN, NA, CL, TSN | — |
| 5G0G | Crystal structure of danio rerio HDAC6 CD1 in complex with trichostatin a | x-ray diffraction | A | — | — |
| 5G0H | Crystal structure of Danio rerio HDAC6 CD2 in complex with (S)- trichostatin A | x-ray diffraction | A | E1Z, K, ZN | — |
| 5G0H | Crystal structure of danio rerio HDAC6 CD2 in complex with ( S)-trichostatin a | x-ray diffraction | A | — | — |
| 5G0I | Crystal structure of Danio rerio HDAC6 CD1 and CD2 (linker cleaved) in complex with Nexturastat A | x-ray diffraction | A, B | ZN, K, N4R, CL | — |
| 5G0I | Crystal structure of danio rerio HDAC6 CD1 and CD2 (linker cleaved) in complex with nexturastat a | x-ray diffraction | A, B | — | — |
| 5G0J | Crystal structure of Danio rerio HDAC6 CD1 and CD2 (linker intact) in complex with Nexturastat A | x-ray diffraction | A | CL, ZN, K, N4R | — |
| 5G0J | Crystal structure of danio rerio HDAC6 CD1 and CD2 (linker intact) in complex with nexturastat a | x-ray diffraction | A | — | — |
| 6R0K | X-ray structure of danio rerio histone deacetylase 6 (HDAC6) CD2 in complex with a inhibitor SS208 | x-ray diffraction | A | ZN, K, JNN, SCN | — |
| 6TCY | X-ray structure of Danio rerio histone deacetylase 6 (HDAC6) CD2 in complex with a inhibitor SS555 | x-ray diffraction | AAA, BBB | ZN, K, N28, TOE, CL | 3 (best 0.52) |
| 6THV | X-ray structure of the danio rerio histone deacetylase 6 (HDAC6; catalytic domain 2) in complex… | x-ray diffraction | A | ZN, K, SCN, NA, N9W | — |
| 6UO2 | Crystal structure of Danio rerio histone deacetylase 6 catalytic domain 1 (CD1) complexed with… | x-ray diffraction | A, B | ZN, K, TSN | 1 (best 0.80) |
| 6UO2 | Crystal structure of danio rerio histone deacetylase 6 catalytic domain 1 (CD1) complexed with… | x-ray diffraction | A, B | ZN, K, TSN | — |
| 6UO3 | Crystal structure of Danio rerio histone deacetylase 6 catalytic domain 1 (CD1) complexed with AR-42 | x-ray diffraction | A | ZN, K, QCP | 1 (best 0.45) |
| 6UO3 | Crystal structure of danio rerio histone deacetylase 6 catalytic domain 1 (CD1) complexed with ar-42 | x-ray diffraction | A | ZN, K, QCP | — |
| 6UO4 | Crystal structure of danio rerio histone deacetylase 6 catalytic domain 1 (CD1) Y363F mutant… | x-ray diffraction | A, B | ZN, K, TSN | — |
| 6UO5 | Crystal structure of danio rerio histone deacetylase 6 catalytic domain 1 (CD1) Y363F mutant… | x-ray diffraction | A | QCP, ZN, K | — |
| 6UO7 | Crystal structure of Danio rerio histone deacetylase 6 catalytic domain 1 (CD1) K330L mutant… | x-ray diffraction | A | ZN, K, QCP | — |
| 6UO7 | Crystal structure of danio rerio histone deacetylase 6 catalytic domain 1 (CD1) K330L mutant… | x-ray diffraction | A | ZN, K, QCP | — |
| 6UOB | Crystal structure of Danio rerio histone deacetylase 6 catalytic domain 1 (CD1) K330L mutant… | x-ray diffraction | A, B | PHE, ZN, K, P7D | 2 (best 0.76) |
| 6UOB | Crystal structure of danio rerio histone deacetylase 6 catalytic domain 1 (CD1) K330L mutant… | x-ray diffraction | A, B | ZN, K, P7D | — |
| 6UOC | Crystal structure of danio rerio histone deacetylase 6 catalytic domain 1 (CD1) K330L mutant… | x-ray diffraction | A | ZN, K, QCM | — |
| 6WYO | Crystal structure of danio rerio histone deacetylase 6 catalytic domain 1 (CD1) H82F F202Y double… | x-ray diffraction | A, B | ZN, K, TSN | — |
| 6WYP | Crystal structure of Danio rerio histone deacetylase 6 catalytic domain 1 (CD1) K330L mutant… | x-ray diffraction | A | ZN, K, UFS | — |
| 6WYP | Crystal structure of danio rerio histone deacetylase 6 catalytic domain 1 (CD1) K330L mutant… | x-ray diffraction | A | ZN, K, UFS | — |
| 6WYQ | Crystal structure of Danio rerio histone deacetylase 6 catalytic domain 1 (CD1) K330L mutant… | x-ray diffraction | A, B | ZN, K, UFJ | 1 (best 0.79) |
| 6WYQ | Crystal structure of danio rerio histone deacetylase 6 catalytic domain 1 (CD1) K330L mutant… | x-ray diffraction | A, B | ZN, K, UFJ | — |
| 6ZW1 | X-ray structure of Danio rerio histone deacetylase 6 (HDAC6) CD2 in complex with an inhibitor SW101 | x-ray diffraction | A | ZN, QRB, K, SCN | — |
| 6ZW1 | X-ray structure of danio rerio histone deacetylase 6 (HDAC6) CD2 in complex with an inhibitor SW101 | x-ray diffraction | A | ZN, QRB, K, SCN | — |
| 7O2P | Crystal structure of Danio rerio histone deacetylase 6 catalytic domain 2 in complex with ITF3756 | x-ray diffraction | A, B | UZW, ZN, K, IOD | 3 (best 0.83) |
| 7O2P | Crystal structure of danio rerio histone deacetylase 6 catalytic domain 2 in complex with ITF3756 | x-ray diffraction | A, B | UZW, ZN, K, IOD | — |
| 7O2R | Crystal structure of Danio rerio histone deacetylase 6 catalytic domain 2 in complex with ITF3985 | x-ray diffraction | A | V05, ZN, IOD, K | 1 (best 0.28) |
| 7O2R | Crystal structure of danio rerio histone deacetylase 6 catalytic domain 2 in complex with ITF3985 | x-ray diffraction | A | V05, ZN, IOD, K | — |
| 7QNO | Crystal structure of ligand-free Danio rerio HDAC6 CD1 CD2 | x-ray diffraction | A | PRO, K, ZN | 5 (best 0.59) |
| 7QNO | Crystal structure of ligand-free danio rerio HDAC6 CD1 CD2 | x-ray diffraction | A | K, ZN | — |
| 8A8Z | Crystal structure of Danio rerio HDAC6 CD2 in complex with in situ enzymatically hydrolyzed… | x-ray diffraction | A, B | LDL, ZN, K | 2 (best 0.61) |
| 8QA7 | Crystal structure of HDAC6 catalytic domain 2 from zebrafish in complex with buffer component. | x-ray diffraction | A, B | K, ZN | 3 (best 0.56) |
| 9GGH | Crystal structure of Danio rerio histone deacetylase 6 catalytic domain 2 (CD2) in complex with… | x-ray diffraction | A | A1IKY, ZN | — |
| 9GGK | Crystal structure of Danio rerio histone deacetylase 6 catalytic domain 2 (CD2) in complex with… | x-ray diffraction | A | A1IK2, ZN | — |
Ligands
- ZN · Zinc ion · in 36 records
- K · Potassium ion · in 32 records
- TSN · Trichostatin A · in 6 records
- QCP · Ar-42 · in 5 records
- CL · Chloride ion · in 4 records
- IOD · Iodide ion · in 4 records
- SCN · Thiocyanate ion · in 4 records
- N4R · Nexturastat A · in 2 records
- NA · Sodium ion · in 2 records
- P7D · Resminostat · in 2 records
- QRB · 1-[[4-(oxidanylcarbamoyl)phenyl]methyl]-3,4-dihydro-2~{H}-quinoline-6-carboxamide · in 2 records
- UFJ · N~1~-hydroxy-N~8~-(4-iodophenyl)octanediamide · in 2 records
- UFS · N~1~-(4-{4-[(hex-5-ynoyl)amino]benzene-1-carbonyl}phenyl)-N~8~-hydroxyoctanediamide · in 2 records
- UZW · ~{N}-oxidanyl-4-[(5-thiophen-2-yl-1,2,3,4-tetrazol-1-yl)methyl]benzamide · in 2 records
- V05 · 3,5-bis(fluoranyl)-~{N}-oxidanyl-4-[(5-pyrimidin-2-yl-1,2,3,4-tetrazol-2-yl)methyl]benzamide · in 2 records
- A1IK2 · 4-(4-methoxyphenyl)-~{N}-[6-(oxidanylamino)-6-oxidanylidene-hexoxy]-1,3-thiazole-2-carboxamide · in 1 record
- A1IKY · ~{N}-[6-(oxidanylamino)-6-oxidanylidene-hexoxy]-4-(4-pyrrolidin-1-ylphenyl)-1,3-thiazolidine-2-carboxamide · in 1 record
- E1Z · S-Trichostatin A · in 1 record
- JNN · 5-[2-[(3,4-dichlorophenyl)carbonylamino]ethyl]-~{N}-oxidanyl-1,2-oxazole-3-carboxamide · in 1 record
- LDL · 4-[[4-[4-(imidazolidin-2-ylideneamino)phenyl]-1,2,3-triazol-1-yl]methyl]benzohydrazide · in 1 record
- N28 · 4-[[[4-(aminomethyl)phenyl]carbamoyl-(4-oxidanylbutyl)amino]methyl]-~{N}-oxidanyl-benzamide · in 1 record
- N9W · 4-[(2-methyl-3,4-dihydro-1~{H}-pyrido[4,3-b]indol-5-yl)methyl]-~{N}-oxidanyl-benzamide · in 1 record
- NH4 · Ammonium ion · in 1 record
- PHE · Phenylalanine · in 1 record
- PRO · Proline · in 1 record
- QCM · Givinostat · in 1 record
- SO4 · Sulfate ion · in 1 record
- TOE · 2-[2-(2-methoxy-ethoxy)-ethoxy]-ethoxyl · in 1 record
Elsewhere
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