UniProt E0SJQ4
Erwinia chrysanthemi ligand-gated ion channel (E0SJQ4)
Erwinia chrysanthemi ligand-gated ion channel (UniProt E0SJQ4): 36 experimental structures on GenesisL1, 8 ligands bound, 35 pockets. Binding sites, pockets, druggability and 3D structures in GL1X.
- UniProt
- E0SJQ4
- Protein
- Erwinia chrysanthemi ligand-gated ion channel
- Experimental structures
- 36
- Predicted models
- 0
- Ligands
- 8
- Pockets
- 35 · 2 records with a druggable one
Structures
36 records of E0SJQ4 in the MolNFT archive: 36 experimental, 0 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 2YN6 | Pentameric Ligand-Gated Ion Channel ELIC in Complex with Barium | x-ray diffraction | A, B, C, D, E | — | — |
| 2YN6 | Pentameric ligand-gated ion channel elic in complex with barium | x-ray diffraction | A, B, C, D, E | — | — |
| 3RQU | Crystal structure of a prokaryotic pentameric ligand-gated ion channel, ELIC | x-ray diffraction | A, B, C, D, E, F, G, H, I, J | — | — |
| 3RQU | Crystal structure of a prokaryotic pentameric ligand-gated ion channel, elic | x-ray diffraction | A, B, C, D, E, F, G, H, I, J | — | — |
| 3RQW | Crystal structure of acetylcholine bound to a prokaryotic pentameric ligand-gated ion channel, ELIC | x-ray diffraction | A, B, C, D, E, F, G, H, I, J | — | — |
| 3RQW | Crystal structure of acetylcholine bound to a prokaryotic pentameric ligand-gated ion channel, elic | x-ray diffraction | A, B, C, D, E, F, G, H, I, J | — | — |
| 3UQ4 | X-ray structure of a pentameric ligand gated ion channel from Erwinia chrysanthemi (ELIC) mutant… | x-ray diffraction | A, B, C, D, E, F, G, H, I, J | — | — |
| 3UQ4 | X-ray structure of a pentameric ligand gated ion channel from erwinia chrysanthemi (elic) mutant… | x-ray diffraction | A, B, C, D, E, F, G, H, I, J | — | — |
| 3UQ5 | X-ray structure of a pentameric ligand gated ion channel from Erwinia chrysanthemi (ELIC) mutant… | x-ray diffraction | A, B, C, D, E, F, G, H, I, J | — | — |
| 3UQ5 | X-ray structure of a pentameric ligand gated ion channel from erwinia chrysanthemi (elic) mutant… | x-ray diffraction | A, B, C, D, E, F, G, H, I, J | — | — |
| 3UQ7 | X-ray structure of a pentameric ligand gated ion channel from Erwinia chrysanthemi (ELIC) mutant… | x-ray diffraction | A, B, C, D, E, F, G, H, I, J | — | — |
| 3UQ7 | X-ray structure of a pentameric ligand gated ion channel from erwinia chrysanthemi (elic) mutant… | x-ray diffraction | A, B, C, D, E, F, G, H, I, J | — | — |
| 4Z90 | ELIC bound with the anesthetic isoflurane in the resting state | x-ray diffraction | A, B, C, D, E, F, G, H, I, J | — | — |
| 4Z90 | Elic bound with the anesthetic isoflurane in the resting state | x-ray diffraction | A, B, C, D, E, F, G, H, I, J | — | — |
| 4Z91 | ELIC cocrystallized with isofluorane in a desensitized state | x-ray diffraction | A, B, C, D, E, F, G, H, I, J | — | — |
| 4Z91 | Elic cocrystallized with isofluorane in a desensitized state | x-ray diffraction | A, B, C, D, E, F, G, H, I, J | — | — |
| 5HEJ | Pentameric ligand-gated ion channel ELIC mutant F116A | x-ray diffraction | A, B, C, D, E, F, G, H, I, J | — | — |
| 5HEJ | Pentameric ligand-gated ion channel elic mutant F116A | x-ray diffraction | A, B, C, D, E, F, G, H, I, J | — | — |
| 5HEO | Pentameric ligand-gated ion channel ELIC mutant P254G | x-ray diffraction | A, B, C, D, E, F, G, H, I, J | — | — |
| 5HEO | Pentameric ligand-gated ion channel elic mutant P254G | x-ray diffraction | A, B, C, D, E, F, G, H, I, J | — | — |
| 5HEU | Pentameric ligand-gated ion channel ELIC mutant A257Y | x-ray diffraction | A, B, C, D, E, F, G, H, I, J | — | — |
| 5HEU | Pentameric ligand-gated ion channel elic mutant A257Y | x-ray diffraction | A, B, C, D, E, F, G, H, I, J | — | — |
| 5HEW | Pentameric ligand-gated ion channel ELIC mutant T28D | x-ray diffraction | A, B, C, D, E, F, G, H, I, J | — | — |
| 5HEW | Pentameric ligand-gated ion channel elic mutant T28D | x-ray diffraction | A, B, C, D, E, F, G, H, I, J | — | — |
| 5LG3 | X-ray structure of a pentameric ligand gated ion channel from erwinia chrysanthemi (elic) in… | x-ray diffraction | A, B, C, D, E, F, G, H, I, J | Z80 | — |
| 5SXU | X-ray structure of 2-bromoethanol bound to a pentameric ligand gated ion channel (elic) in a… | x-ray diffraction | A, B, C, D, E, F, G, H, I, J | BRJ, 3CN, CL | — |
| 6CDU | Crystal structure of a chimeric human alpha1GABAA receptor in complex with alphaxalone | x-ray diffraction | A, B, C, D, E, F, G, H, I, J | EY4 | — |
| 6CDU | Crystal structure of a chimeric human ALPHA1GABAA receptor in complex with alphaxalone | x-ray diffraction | A, B, C, D, E, F, G, H, I, J | EY4 | — |
| 6D1S | Crystal structure of an apo chimeric human ALPHA1GABAA receptor | x-ray diffraction | A, B, C, D, E, F, G, H, I, J | — | — |
| 6V03 | Elic-propylammonium complex in popc-only nanodiscs | electron microscopy | A, B, C, D, E | 3CN | — |
| 6V0B | Unliganded elic in popc-only nanodiscs. | electron microscopy | A, B, C, D, E | — | — |
| 7L6Q | Unliganded elic in styrene-maleic-acid nanodiscs at 2.5-ångström resolution | electron microscopy | A, B, C, D, E | PGW, CDL | — |
| 7L6U | Unliganded elic in popc-only nanodiscs at 3.3-ångström resolution | electron microscopy | A, B, C, D, E | — | — |
| 8D63 | ELIC apo in POPC nanodisc | electron microscopy | A, B, C, D, E | LBN | — |
| 8F32 | ELIC with Propylamine in SMA nanodiscs with 2:1:1 POPC:POPE:POPG | electron microscopy | E, D, C, B, A | 3CN | 20 (best 0.84) |
| 8TWZ | ELIC with Propylamine in spNW15 nanodiscs with 2:1:1 POPC:POPE:POPG | electron microscopy | A, B, C, D, E | 3CN | 15 (best 0.71) |
Ligands
- 3CN · 3-aminopropane · in 4 records
- EY4 · (3a,5a)-3-Hydroxypregnane-11,20-dione · in 2 records
- BRJ · 2-bromoethanol · in 1 record
- CDL · Cardiolipin · in 1 record
- CL · Chloride ion · in 1 record
- LBN · 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine · in 1 record
- PGW · (1R)-2-{[(S)-{[(2S)-2,3-dihydroxypropyl]oxy}(hydroxy) phosphoryl]oxy}-1-[(hexadecanoyloxy)methyl]ethyl (9Z)-octadec-9-enoate · in 1 record
- Z80 · 3-(2-chloro-10H-phenothiazin-10-yl)-N,N-dimethylpropan-1-amine · in 1 record
Experiment against prediction
- 6D1S chain H against the predicted model P14867: TM-score 0.90, RMSD 1.73 Å
- 6D1S chain E against the predicted model P14867: TM-score 0.90, RMSD 1.77 Å
- 6D1S chain C against the predicted model P14867: TM-score 0.90, RMSD 1.80 Å
- 6D1S chain F against the predicted model P14867: TM-score 0.90, RMSD 1.77 Å
- 6D1S chain G against the predicted model P14867: TM-score 0.90, RMSD 1.82 Å
- 6D1S chain A against the predicted model P14867: TM-score 0.90, RMSD 1.80 Å
- 6D1S chain J against the predicted model P14867: TM-score 0.90, RMSD 1.84 Å
- 6D1S chain B against the predicted model P14867: TM-score 0.90, RMSD 1.85 Å
- 6D1S chain D against the predicted model P14867: TM-score 0.90, RMSD 1.83 Å
- 6CDU chain J against the predicted model P14867: TM-score 0.90, RMSD 2.02 Å
Elsewhere
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