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Ligand · 4LE

4LE · (2R)-2-chloro-2-(difluoromethoxy)-1,1,1-trifluoroethane

4LE, (2R)-2-chloro-2-(difluoromethoxy)-1,1,1-trifluoroethane (C3 H2 Cl F5 O, 184.5 g/mol), in the MolNFT structures on GenesisL1: bound in 4 records (2 PDB entries). Every binding site with its residues within 4.5 Å, the residues it binds…

Component
4LE
Formula
C3 H2 Cl F5 O
Class
ligand
Structures
4
PDB entries
2

Binding sites

4LE in 4 structures; the first of them:

  • 4Z90 · ELIC bound with the anesthetic isoflurane in the resting state · 4LE A401 · binds LEU240, VAL243, ALA244, LEU240, ALA244, LEU240, ALA244, LEU240 and 2 more
  • 4Z91 · ELIC cocrystallized with isofluorane in a desensitized state · 4LE A401 · binds LEU240, VAL243, ALA244, LEU240, ALA244, LEU240, ALA244, LEU240 and 2 more
  • 4Z90 · Elic bound with the anesthetic isoflurane in the resting state · 4LE A401 · binds LEU240, VAL243, ALA244, LEU240, ALA244, LEU240, ALA244, LEU240 and 2 more
  • 4Z91 · Elic cocrystallized with isofluorane in a desensitized state · 4LE A401 · binds LEU240, VAL243, ALA244, LEU240, ALA244, LEU240, ALA244, LEU240 and 2 more

Residues it binds most

LEU 16, THR 8, ALA 8, VAL 4 (residue and the binding sites it lines).

Found with

  • MES · 2-(N-morpholino)-ethanesulfonic acid
  • 4LJ · 1.7.6 3-bromanylpropan-1-amine

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