UniProt C3W5S0
Polymerase acidic protein (C3W5S0)
Polymerase acidic protein (UniProt C3W5S0), EC 3.1.-.-: 112 experimental structures on GenesisL1, 56 ligands bound, 16 pockets. Binding sites, pockets, druggability and 3D structures in GL1X.
- UniProt
- C3W5S0
- Protein
- Polymerase acidic protein
- EC
- 3.1.-.-
- Experimental structures
- 112
- Predicted models
- 0
- Ligands
- 56
- Pockets
- 16 · 16 records with a druggable one
Structures
112 records of C3W5S0 in the MolNFT archive: 112 experimental, 0 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 4AVG | Influenza strain pH1N1 2009 polymerase subunit PA endonuclease in complex with diketo compound 2 | x-ray diffraction | A, B, C, D | — | — |
| 4AVG | Influenza strain PH1N1 2009 polymerase subunit pa endonuclease in complex with diketo compound 2 | x-ray diffraction | A, B, C, D | — | — |
| 4AVL | Influenza strain pH1N1 2009 polymerase subunit PA endonuclease in complex with dTMP | x-ray diffraction | A, B, C, D | — | — |
| 4AVL | Influenza strain PH1N1 2009 polymerase subunit pa endonuclease in complex with dtmp | x-ray diffraction | A, B, C, D | — | — |
| 4AVQ | Influenza strain pH1N1 2009 polymerase subunit PA endonuclease | x-ray diffraction | A, B, C, D | — | — |
| 4AVQ | Influenza strain PH1N1 2009 polymerase subunit pa endonuclease | x-ray diffraction | A, B, C, D | — | — |
| 4AWF | Influenza strain pH1N1 2009 polymerase subunit PA endonuclease in complex with 2… | x-ray diffraction | A, B, C, D | — | — |
| 4AWF | Influenza strain PH1N1 2009 polymerase subunit pa endonuclease in complex with 2… | x-ray diffraction | A, B, C, D | — | — |
| 4AWG | Influenza strain pH1N1 2009 polymerase subunit PA endonuclease in complex with diketo compound 3 | x-ray diffraction | A, B, C, D | — | — |
| 4AWG | Influenza strain PH1N1 2009 polymerase subunit pa endonuclease in complex with diketo compound 3 | x-ray diffraction | A, B, C, D | — | — |
| 4AWH | Influenza strain pH1N1 2009 polymerase subunit PA endonuclease in complex with rUMP | x-ray diffraction | A, B, C, D | — | — |
| 4AWH | Influenza strain PH1N1 2009 polymerase subunit pa endonuclease in complex with rump | x-ray diffraction | A, B, C, D | — | — |
| 4AWK | Influenza strain pH1N1 2009 polymerase subunit PA endonuclease in complex with diketo compound 1 | x-ray diffraction | A | — | — |
| 4AWK | Influenza strain PH1N1 2009 polymerase subunit pa endonuclease in complex with diketo compound 1 | x-ray diffraction | A | — | — |
| 4AWM | Influenza strain pH1N1 2009 polymerase subunit PA endonuclease in complex with (-)-epigallocatechin… | x-ray diffraction | A | — | — |
| 4AWM | Influenza strain PH1N1 2009 polymerase subunit pa endonuclease in complex with (-)-epigallocatechin… | x-ray diffraction | A | — | — |
| 5CCY | 2009 H1N1 PA endonuclease in complex with dTMP | x-ray diffraction | A | MN, TMP | 1 (best 0.65) |
| 5CCY | 2009 H1N1 pa endonuclease in complex with dtmp | x-ray diffraction | A | — | — |
| 5CGV | 2009 H1N1 pa endonuclease in complex with L-742,001 | x-ray diffraction | A | — | — |
| 5CL0 | 2009 H1N1 PA endonuclease in complex with rUMP | x-ray diffraction | A | MN, U5P | 1 (best 0.66) |
| 5CL0 | 2009 H1N1 pa endonuclease in complex with rump | x-ray diffraction | A | — | — |
| 5CZN | 2009 H1N1 pa endonuclease mutant E119D | x-ray diffraction | A | — | — |
| 5D2O | 2009 H1N1 pa endonuclease mutant F105S | x-ray diffraction | A | — | — |
| 5D42 | 2009 H1N1 PA endonuclease mutant F105S in complex with dTMP | x-ray diffraction | A | MN, TMP | 1 (best 0.61) |
| 5D42 | 2009 H1N1 pa endonuclease mutant F105S in complex with dtmp | x-ray diffraction | A | — | — |
| 5D4G | 2009 H1N1 PA endonuclease mutant F105S in complex with rUMP | x-ray diffraction | A | MN, U5P | — |
| 5D4G | 2009 H1N1 pa endonuclease mutant F105S in complex with rump | x-ray diffraction | A | — | — |
| 5D8U | 2009 H1N1 PA endonuclease mutant E119D in complex with L-742,001 | x-ray diffraction | A | MN, 0N8 | 1 (best 0.60) |
| 5D8U | 2009 H1N1 pa endonuclease mutant E119D in complex with L-742,001 | x-ray diffraction | A | — | — |
| 5D9J | 2009 H1N1 pa endonuclease mutant F105S in complex with L-742,001 | x-ray diffraction | A | — | — |
| 5DBS | 2009 H1N1 pa endonuclease mutant E119D in complex with dtmp | x-ray diffraction | A | — | — |
| 5DEB | 2009 H1N1 pa endonuclease mutant E119D in complex with rump | x-ray diffraction | A | — | — |
| 5DES | 2009 H1N1 PA endonuclease domain | x-ray diffraction | A | MN | — |
| 5DES | 2009 H1N1 pa endonuclease domain | x-ray diffraction | A | — | — |
| 5EGA | 2009 H1N1 PA endonuclease domain in complex with an N-acylhydrazone inhibitor | x-ray diffraction | A | MN, GK0 | — |
| 5EGA | 2009 H1N1 pa endonuclease domain in complex with an N-acylhydrazone inhibitor | x-ray diffraction | A | — | — |
| 5VP8 | I38T mutant of 2009 H1N1 pa endonuclease | x-ray diffraction | A | MN, SO4, 9HD | — |
| 5VPT | 2009 H1N1 pa endonuclease in complex with ro-7 | x-ray diffraction | A | MN, SO4, R07 | — |
| 5VPX | I38T mutant of 2009 H1N1 pa endonuclease in complex with ro-7 | x-ray diffraction | A | MN, SO4, R07 | — |
| 5VQN | E119D mutant of 2009 H1N1 pa endonuclease in complex with ro-7 | x-ray diffraction | A | MN, SO4, R07 | — |
| 5VRJ | 2009 H1N1 pa endonuclease in complex with ro-7 and magnesium | x-ray diffraction | A | SO4, MG, R07 | — |
| 5W3I | Crystal structure of the influenza virus pa endonuclease in complex with inhibitor 6E (sri-29685) | x-ray diffraction | A | MN, GY5 | — |
| 5W44 | Crystal structure of the influenza virus pa endonuclease in complex with inhibitor 7A (sri-29770) | x-ray diffraction | A | MN, GY6, MG, NA | — |
| 5W73 | Crystal structure of the influenza virus pa endonuclease in complex with inhibitor 9F (sri-29835) | x-ray diffraction | A | MN, SO4, GY9 | — |
| 5W7U | Crystal structure of the influenza virus pa endonuclease in complex with inhibitor 8F (sri-29928) | x-ray diffraction | A | MN, GY8 | — |
| 5W92 | Crystal structure of the influenza virus PA endonuclease in complex with an inhibitor - SRI-30049 | x-ray diffraction | A | MN, KU0, 9HD | 1 (best 0.68) |
| 5W92 | Crystal structure of the influenza virus pa endonuclease in complex with an inhibitor - sri-30049 | x-ray diffraction | A | MN, KU0, 9HD | — |
| 5W9G | Crystal structure of the influenza virus pa endonuclease in complex with inhibitor 9K (sri-30023) | x-ray diffraction | A | MN, CL, KU2, SO4 | — |
| 5WA6 | Crystal structure of the influenza virus pa endonuclease in complex with an inhibitor - sri-30007 | x-ray diffraction | A | MN, KU7 | — |
| 5WA7 | Crystal structure of the influenza virus pa endonuclease in complex with inhibitor 9B (sri-30101) | x-ray diffraction | A | MN, SO4, KU4 | — |
| 5WAP | Crystal structure of the influenza virus PA endonuclease in complex with inhibitor 10i (SRI-30025) | x-ray diffraction | A | MN, SO4, KU9 | 1 (best 0.65) |
| 5WAP | Crystal structure of the influenza virus pa endonuclease in complex with inhibitor 10I (sri-30025) | x-ray diffraction | A | MN, SO4, KU9 | — |
| 5WB3 | Crystal structure of the influenza virus pa endonuclease in complex with inhibitor 10J (sri-30026) | x-ray diffraction | A | MN, SO4, GYA | — |
| 5WCS | Crystal structure of the influenza virus pa endonuclease in complex with inhibitor 6B (sri-29789) | x-ray diffraction | A | MN, 9KU | — |
| 5WCT | Crystal structure of the influenza virus pa endonuclease in complex with inhibitor 6C (sri-29775) | x-ray diffraction | A | MN, GY4 | — |
| 5WDC | Crystal structure of the influenza virus pa endonuclease in complex with inhibitor 9E (sri-29843) | x-ray diffraction | A | MN, SO4, G2K | — |
| 5WDN | Crystal structure of the influenza virus pa endonuclease in complex with inhibitor 6D (sri-29680) | x-ray diffraction | A | MN, G1K | — |
| 5WDW | Crystal structure of the influenza virus PA endonuclease in complex with inhibitor 10k (SRI-30027) | x-ray diffraction | A | MN, 8KU | — |
| 5WDW | Crystal structure of the influenza virus pa endonuclease in complex with inhibitor 10K (sri-30027) | x-ray diffraction | A | MN, 8KU | — |
| 5WE7 | Crystal structure of the influenza virus pa endonuclease in complex with an inhibitor - sri-29782 | x-ray diffraction | A | MN, G3K, MLT | — |
52 records more on the page itself.
Ligands
- MN · Manganese (II) ion · in 82 records
- SO4 · Sulfate ion · in 40 records
- QQ4 · Hexa Vinylpyrrolidone K15 · in 18 records
- 09Y · 5-hydroxy-N-[2-(2-methoxypyridin-4-yl)ethyl]-2-(2-methylphenyl)-6-oxo-1,6-dihydropyrimidine-4-carboxamide · in 4 records
- E4Z · Baloxavir acid · in 4 records
- GY6 · 2-[(2S)-1-(2,6-dichlorobenzene-1-carbonyl)pyrrolidin-2-yl]-5-hydroxy-6-oxo-N-(2-phenylethyl)-1,6-dihydropyrimidine-4-carboxamide · in 4 records
- R07 · 1-[(11S)-6,11-dihydrodibenzo[b,e]thiepin-11-yl]-5-hydroxy-3-[(2R)-1,1,1-trifluoropropan-2-yl]-2,3-dihydro-1H-pyrido[2,1-f][1,2,4]triazine-4,6-dione · in 4 records
- 9HD · 1-[(3R,5S,7R)-1,5,7,9-tetrakis(2-oxopyrrolidin-1-yl) nonan-3-yl]-1,3-dihydro-2H-pyrrol-2-one · in 3 records
- GYA · 2-[(2S)-1-{[(2-chlorophenyl)sulfanyl]acetyl}pyrrolidin-2-yl]-N-(5,6-dimethoxy-2,3-dihydro-1H-inden-2-yl)-5-hydroxy-6-oxo-1,6-dihydropyrimidine-4-carboxamide · in 3 records
- KU0 · 2-[(2S)-1-(3,5-dichloropyridine-4-carbonyl)pyrrolidin-2-yl]-5-hydroxy-6-oxo-N-[2-(phenylsulfonyl)ethyl]-1,6-dihydropyrimidine-4-carboxamide · in 3 records
- KU4 · 2-{(2S)-1-[3-(2-chlorophenyl)propanoyl]pyrrolidin-2-yl}-5-hydroxy-6-oxo-N-(2-phenoxyethyl)-1,6-dihydropyrimidine-4-carboxamide · in 3 records
- MG · Magnesium ion · in 3 records
- Y5V · 5-hydroxy-N-[2-(4-hydroxy-3-methoxyphenyl)ethyl]-2-(2-methylphenyl)-6-oxo-1,6-dihydropyrimidine-4-carboxamide · in 3 records
- 8KU · 2-[(2S)-1-{[(2-chlorophenyl)sulfanyl]acetyl}pyrrolidin-2-yl]-N-{[(2S)-2,3-dihydro-1-benzofuran-2-yl]methyl}-5-hydroxy-6-oxo-1,6-dihydropyrimidine-4-carboxamide · in 2 records
- G5V · 5-hydroxy-2-methyl-4-oxo-4H-pyran-3-carboxylic acid · in 2 records
- HOG · 6-(3-carboxyphenyl)-3-hydroxy-4-oxo-1,4-dihydropyridine-2-carboxylic acid · in 2 records
- HRJ · 3-hydroxy-6-[2-methyl-4-(5-oxo-4,5-dihydro-1,2,4-oxadiazol-3-yl)phenyl]-4-oxo-1,4-dihydropyridine-2-carboxylic acid · in 2 records
- IJM · (6M)-3-hydroxy-4-oxo-6-[(4M)-4-(1H-tetrazol-5-yl)-2-(trifluoromethyl)phenyl]-1,4-dihydropyridine-2-carboxylic acid · in 2 records
- KU2 · 2-[(2S)-1-{[(2-chlorophenyl)sulfanyl]acetyl}pyrrolidin-2-yl]-5-hydroxy-6-oxo-N-(2-phenoxyethyl)-1,6-dihydropyrimidine-4-carboxamide · in 2 records
- KU5 · 2-[(2S)-1-{[(2-chlorophenyl)sulfanyl]acetyl}pyrrolidin-2-yl]-5-hydroxy-6-oxo-N-[2-(phenylsulfonyl)ethyl]-1,6-dihydropyrimidine-4-carboxamide · in 2 records
- KU9 · 2-[(2S)-1-{[(2-chlorophenyl)sulfanyl]acetyl}pyrrolidin-2-yl]-N-(2,3-dihydro-1H-inden-2-yl)-5-hydroxy-6-oxo-1, 6-dihydropyrimidine-4-carboxamide · in 2 records
- R1D · 5-hydroxy-N-[2-(4-hydroxy-3-methoxyphenyl)ethyl]-6-oxo-2-[2-(trifluoromethyl)phenyl]-1,6-dihydropyrimidine-4-carboxamide · in 2 records
- R3J · Benzyl [2-(5-hydroxy-4-{[2-(2-methoxypyridin-4-yl) ethyl]carbamoyl}-6-oxo-1,6-dihydropyrimidin-2-yl) propan-2-yl]carbamate · in 2 records
- TMP · Thymidine-5'-phosphate · in 2 records
- U5P · Uridine-5'-monophosphate · in 2 records
- W5V · 2-(2,6-difluorophenyl)-5-hydroxy-N-[2-(2-methoxypyridin-4-yl)ethyl]-6-oxo-3,6-dihydropyrimidine-4-carboxamide · in 2 records
- ZHJ · 5-hydroxy-N-[2-(4-hydroxy-3-methoxyphenyl)ethyl]-6-oxo-2-phenyl-1,6-dihydropyrimidine-4-carboxamide · in 2 records
- 0N8 · (2Z)-4-[1-benzyl-4-(4-chlorobenzyl)piperidin-4-yl]-2-hydroxy-4-oxobut-2-enoic acid · in 1 record
- 0VL · Benzyl {2-[(5S)-5-hydroxy-4-oxo-6-{[2-(pyridin-4-yl) ethyl]carbamoyl}-4,5-dihydropyrimidin-2-yl]propan-2-yl}carbamate · in 1 record
- 5Y1 · (5R)-5-hydroxy-16,21-dioxa-3,8,28-triazatetracyclo[20.3.1.1~2,6~.1~11,15~]octacosa-1(26),2,6(28),11(27),12,14,22,24-octaene-4,7-dione · in 1 record
Elsewhere
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