UniProt A7SLZ2
Stimulator of Interferon Genes (A7SLZ2)
Stimulator of Interferon Genes (UniProt A7SLZ2): 11 experimental structures and 1 predicted model on GenesisL1, 5 ligands bound, 12 pockets. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.
- UniProt
- A7SLZ2
- Protein
- Stimulator of Interferon Genes
- Experimental structures
- 11
- Predicted models
- 1
- Ligands
- 5
- Pockets
- 12 · 4 records with a druggable one
Structures
12 records of A7SLZ2 in the MolNFT archive: 11 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 5CFL | Crystal structure of anemone STING (Nematostella vectensis) in complex with 3', 3' c-di-GMP… | x-ray diffraction | A, B | C2E | 3 (best 0.84) |
| 5CFL | Crystal structure of anemone sting (nematostella vectensis) in complex with 3', 3' C-di-gmp… | x-ray diffraction | A, B | — | — |
| 5CFM | Crystal structure of anemone STING (Nematostella vectensis) in complex with 3', 3' cGAMP, c[G(3'… | x-ray diffraction | A, B | 4BW | 3 (best 0.82) |
| 5CFM | Crystal structure of anemone sting (nematostella vectensis) in complex with 3', 3' cgamp, C[G(3'… | x-ray diffraction | A, B | — | — |
| 5CFN | Crystal structure of anemone sting (nematostella vectensis) in complex with 3',3' C-di-AMP… | x-ray diffraction | A, B | — | — |
| 5CFO | Crystal structure of anemone sting (nematostella vectensis) in apo 'rotated' open conformation | x-ray diffraction | A, B | — | — |
| 5CFP | Crystal structure of anemone sting (nematostella vectensis) 'humanized' F276K in complex with 3'… | x-ray diffraction | A, B | — | — |
| 5CFQ | Crystal structure of anemone STING (Nematostella vectensis) in complex with 2',3' cGAMP… | x-ray diffraction | A, B | SO4, 1SY | 1 (best 0.84) |
| 5CFQ | Crystal structure of anemone sting (nematostella vectensis) in complex with 2',3' cgamp… | x-ray diffraction | A, B | — | — |
| 5CFR | Crystal structure of anemone STING (Nematostella vectensis) in apo 'unrotated' closed conformation | x-ray diffraction | A, B | CA | 4 (best 0.84) |
| 5CFR | Crystal structure of anemone sting (nematostella vectensis) in apo 'unrotated' closed conformation | x-ray diffraction | A, B | — | — |
| A7SLZ2 | AlphaFold monomer V2.0 prediction for stimulator of interferon genes protein (A7SLZ2) | predicted | A | — | 1 (best 0.33) |
Ligands
- 1SY · cGAMP · in 1 record
- 4BW · 2-amino-9-[(2r,3r,3as,5r,7ar,9r,10r,10as,12r,14ar)-9-(6-amino-9H-purin-9-yl)-3,5,10,12-tetrahydroxy-5,12-dioxidooctahydro-2H,7H-difuro[3,2-D:3',2'-J][1,3,7,9, 2,8]tetraoxadiphosphacyclododecin-2-yl]-1,9-dihydro-6H-purin-6-one · in 1 record
- C2E · 9,9'-[(2r,3r,3as,5s,7ar,9r,10r,10as,12s,14ar)-3,5,10, 12-tetrahydroxy-5,12-dioxidooctahydro-2H,7H-difuro[3, 2-D:3',2'-J][1,3,7,9,2, 8]tetraoxadiphosphacyclododecine-2,9-diyl]bis(2-amino-1,9-dihydro-6H-purin-6-one) · in 1 record
- CA · Calcium ion · in 1 record
- SO4 · Sulfate ion · in 1 record
Experiment against prediction
- 5CFQ chain B against the predicted model A7SLZ2: TM-score 0.99, RMSD 0.53 Å
- 5CFQ chain B against the predicted model A7SLZ2: TM-score 0.99, RMSD 0.53 Å
- 5CFQ chain A against the predicted model A7SLZ2: TM-score 0.99, RMSD 0.60 Å
- 5CFQ chain A against the predicted model A7SLZ2: TM-score 0.99, RMSD 0.60 Å
- 5CFO chain A against the predicted model A7SLZ2: TM-score 0.98, RMSD 0.90 Å
- 5CFP chain A against the predicted model A7SLZ2: TM-score 0.98, RMSD 0.90 Å
- 5CFN chain B against the predicted model A7SLZ2: TM-score 0.97, RMSD 0.89 Å
- 5CFN chain A against the predicted model A7SLZ2: TM-score 0.97, RMSD 0.94 Å
- 5CFL chain A against the predicted model A7SLZ2: TM-score 0.96, RMSD 0.86 Å
- 5CFL chain A against the predicted model A7SLZ2: TM-score 0.96, RMSD 0.86 Å
Elsewhere
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