MolNFT v1 · #115310 · protein
Crystal structure of anemone sting (nematostella vectensis) in complex with 2',3' cgamp, C[G(2',5')PA(3',5')P]
5CFQ · Stimulator of interferon genes: “Crystal structure of anemone sting (nematostella vectensis) in complex with 2',3' cgamp, C[G(2',5')PA(3',5')P]”. X-ray diffraction, 2 ligands (1SY, SO4), 1 pocket (best druggability 0.84). MolNFT v1…
- PDB
- 5CFQ
- Type
- protein
- Length
- 359 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Stimulator of interferon genes
- UniProt
- A7SLZ2
- Ligands
- 1SY, SO4
- Pockets
- 1 · best druggability 0.84
Structure
x-ray diffraction · 2 distinct chains · 40% helix, 25% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Stimulator of interferon genes | protein | 180 | 41% helix, 25% strand | A7SLZ2 |
| B | Stimulator of interferon genes | protein | 179 | 39% helix, 25% strand | A7SLZ2 |
Ligands and binding sites
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
1 pocket found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 324 | 0.84 | 0.94 | 35 | 1SY |
Interfaces
1 interface between chains.
- A–B · 1732 Ų buried · 29 hydrogen bonds · protein-protein
Compared structures
- 5CFQ · Crystal structure of anemone STING (Nematostella vectensis) in complex with 2',3' cGAMP… · the same entry in another collection · chain A against A, TM-score 1.00
- A7SLZ2 · AlphaFold monomer V2.0 prediction for stimulator of interferon genes protein (A7SLZ2) · a predicted model of the same protein · chain B against A, TM-score 0.99
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt A7SLZ2
- Elsewhere: RCSB PDB 5CFQ · PDBe 5CFQ · UniProt A7SLZ2
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